{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:47:54Z","timestamp":1785678474772,"version":"3.56.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1097\/pas.0b013e31826f042c","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T11:57:16Z","timestamp":1358942236000},"page":"399-405","source":"Crossref","is-referenced-by-count":60,"title":["Islet-1 Is a Sensitive But Not Entirely Specific Marker for Pancreatic Neuroendocrine Neoplasms and Their Metastases"],"prefix":"10.1097","volume":"37","author":[{"given":"Rondell P.","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijayee","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolette L.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Smyrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Grogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo V.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210131","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1385\/EP:15:3:247","article-title":"Cdx2 as a marker for neuroendocrine neoplasms of unknown primary sites.","volume":"15","author":"Erickson","year":"2004","journal-title":"Endocr Pathol"},{"key":"R2-10-20210131","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1309\/UKN6PVRKXHG422DA","article-title":"Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids.","volume":"123","author":"Saqi","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"R3-10-20210131","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/cncr.11105","article-title":"5-decade analysis of 13,715 carcinoid neoplasms.","volume":"97","author":"Modlin","year":"2003","journal-title":"Cancer"},{"key":"R4-10-20210131","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/(SICI)1097-0142(19970215)79:4<813::AID-CNCR19>3.0.CO;2-2","article-title":"An analysis of 8305 cases of carcinoid neoplasms.","volume":"79","author":"Modlin","year":"1997","journal-title":"Cancer"},{"key":"R5-10-20210131","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1200\/JCO.2010.33.2056","article-title":"Future directions in the treatment of neuroendocrine neoplasms: consensus report of the National Cancer Institute Neuroendocrine Neoplasm clinical trials planning meeting.","volume":"29","author":"Kulke","year":"2011","journal-title":"J Clin Oncol"},{"key":"R6-10-20210131","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/01.pas.0000131531.75602.b9","article-title":"CDX-2 homeobox gene product expression in neuroendocrine neoplasms: its role as a marker of intestinal neuroendocrine neoplasms.","volume":"28","author":"Barbareschi","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"R7-10-20210131","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.humpath.2004.02.016","article-title":"TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location.","volume":"35","author":"Du","year":"2004","journal-title":"Hum Pathol"},{"key":"R8-10-20210131","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/PAS.0b013e3181ac675b","article-title":"KIT is an independent prognostic marker for pancreatic endocrine neoplasms: a finding derived from analysis of islet cell differentiation markers.","volume":"33","author":"Zhang","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"R9-10-20210131","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/PAS.0b013e318158a397","article-title":"Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine neoplasms and their metastases.","volume":"32","author":"Schmitt","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"R10-10-20210131","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/modpathol.2012.34","article-title":"Value of Islet 1 and PAX8 in identifying metastatic neuroendocrine neoplasms of pancreatic origin.","volume":"25","author":"Koo","year":"2012","journal-title":"Mod Pathol"},{"key":"R11-10-20210131","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/dvdy.10460","article-title":"Gene regulatory factors in pancreatic development.","volume":"229","author":"Jensen","year":"2004","journal-title":"Dev Dyn"},{"key":"R12-10-20210131","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/385257a0","article-title":"Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells.","volume":"385","author":"Ahlgren","year":"1997","journal-title":"Nature"},{"key":"R13-10-20210131","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/344879a0","article-title":"Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain.","volume":"344","author":"Karlsson","year":"1990","journal-title":"Nature"},{"key":"R14-10-20210131","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1210\/mend-5-11-1633","article-title":"Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1.","volume":"5","author":"Dong","year":"1991","journal-title":"Mol Endocrinol"},{"key":"R15-10-20210131","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0006-291X(02)00480-1","article-title":"Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice.","volume":"294","author":"Mutoh","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"R16-10-20210131","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/gast.2002.31902","article-title":"Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice.","volume":"122","author":"Silberg","year":"2002","journal-title":"Gastroenterology"},{"key":"R17-10-20210131","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/modpathol.3800205","article-title":"The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas.","volume":"17","author":"Kaimaktchiev","year":"2004","journal-title":"Mod Pathol"},{"key":"R18-10-20210131","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/modpathol.3800260","article-title":"Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian neoplasms from metastatic colorectal carcinoma.","volume":"18","author":"Logani","year":"2005","journal-title":"Mod Pathol"},{"key":"R20-10-20210131","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/PAS.0b013e3181da0a20","article-title":"PAX8 Expression in well-differentiated pancreatic endocrine neoplasms: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid neoplasms.","volume":"34","author":"Long","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"R21-10-20210131","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/modpathol.2010.176","article-title":"PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine neoplasms from ileal and pulmonary well-differentiated neuroendocrine neoplasms and pancreatic acinar cell carcinoma.","volume":"24","author":"Sangoi","year":"2011","journal-title":"Mod Pathol"},{"key":"R22-10-20210131","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00418-011-0866-3","article-title":"Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine neoplasms.","volume":"136","author":"Lorenzo","year":"2011","journal-title":"Histochem Cell Biol"},{"key":"R23-10-20210131","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1053\/hupa.2001.28245","article-title":"Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine neoplasms.","volume":"32","author":"Cai","year":"2001","journal-title":"Hum Pathol"},{"key":"R24-10-20210131","first-page":"5","article-title":"Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine neoplasms.","volume":"12","author":"Folpe","year":"1999","journal-title":"Mod Pathol"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00000478-201303000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T06:32:20Z","timestamp":1618036340000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000478-201303000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/pas.0b013e31826f042c","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}