{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:27:51Z","timestamp":1783927671258,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1097\/pat.0b013e328340e4d6","type":"journal-article","created":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T07:24:34Z","timestamp":1298532274000},"page":"36-39","source":"Crossref","is-referenced-by-count":19,"title":["Adenocarcinomas associated with perianal fistulae in Crohn\u2019s disease have a rectal, not an anal, immunophenotype"],"prefix":"10.1016","volume":"43","author":[{"given":"Takashi","family":"Nishigami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki R.","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ikeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Torii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Tomitaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Tsujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/PAT.0b013e328340e4d6_bib0005","series-title":"World Health Organization classification oftumors. Pathology and genetics. Tumours ofthe digestive system","first-page":"145","article-title":"Tumours of the anal canal","author":"Fenger","year":"2002"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0010","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11605-009-1061-x","article-title":"Malignant transformation in perianal fistulas of Crohn's disease: a systematic review of literature","volume":"14","author":"Thomas","year":"2010","journal-title":"J Gastrointest Surg"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0015","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1016\/0002-9343(75)90361-7","article-title":"Carcinoma complicating Crohn's disease: report of seven cases and review of the literature","volume":"59","author":"Lightdale","year":"1975","journal-title":"Am J Med"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ncpgasthep1340","article-title":"Diagnosis and management of fistulizing Crohn's disease","volume":"6","author":"Nielsen","year":"2009","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0025","first-page":"273","article-title":"Pathology of the anal glands with special reference to their mucinous histochemistry","volume":"85","author":"Fenger","year":"1977","journal-title":"Acta Path Microbiol Scand (Sect A)"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0030","first-page":"311","article-title":"Case reports - Adenocarcinoma of anal duct origin","volume":"5","author":"Wellman","year":"1962","journal-title":"Can J Surg"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0035","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0046-8177(81)80263-8","article-title":"Primary adenocarcinoma of an anal gland with secondary perianal fistulas","volume":"12","author":"Lee","year":"1981","journal-title":"Hum Pathol"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0040","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1046\/j.1365-2559.2002.1363f.x","article-title":"Adenocarcinoma arising within a Crohn's-related anorectal fistula: a form of anal gland carcinoma?","volume":"40","author":"Wong","year":"2002","journal-title":"Histopathology"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/014107688808100411","article-title":"Carcinoma in anal Crohn's disease","volume":"81","author":"Ball","year":"1988","journal-title":"J R Soc Med"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0050","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/1097-0142(197703)39:3<1295::AID-CNCR2820390341>3.0.CO;2-N","article-title":"Perianal mucinous adenocarcinoma","volume":"39","author":"Prioleau","year":"1977","journal-title":"Cancer"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0055","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1165\/ajrcmb\/7.6.557","article-title":"Mucin genes and the proteins they encode: structure, diversity, and regulation","volume":"7","author":"Gum","year":"1992","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0060","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0959-8049(02)00008-4","article-title":"Cytokeratins 20 and 7 as biomarkers: usefulness in discriminating primary from metastatic adenocarcinoma","volume":"38","author":"Tot","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0065","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.ph.58.030196.001423","article-title":"Intestine-specific gene transcription","volume":"58","author":"Traber","year":"1996","journal-title":"Annu Rev Physiol"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00000478-200303000-00003","article-title":"CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohisto-chemical survey of 476 primary and metastatic carcinomas","volume":"27","author":"Werling","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0075","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1097\/00000478-200112000-00001","article-title":"Differential expression of mucin genes in mammary and extramammary Paget's disease","volume":"25","author":"Kuan","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0080","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/1097-0142(20011015)92:8<2045::AID-CNCR1543>3.0.CO;2-V","article-title":"Anal gland carcinoma","volume":"92","author":"Hobbs","year":"2001","journal-title":"Cancer"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0085","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00795-006-0344-5","article-title":"Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin","volume":"40","author":"Kuroda","year":"2007","journal-title":"Med Mol Morphol"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1023\/A:1025815113599","article-title":"Mucins and mucin binding proteins in colorectal cancer","volume":"23","author":"Byrd","year":"2004","journal-title":"Cancer Metastasis Rev"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0095","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1158\/1078-0432.CCR-09-0401","article-title":"Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer","volume":"15","author":"Baba","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0100","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1136\/gut.2003.038208","article-title":"Morphological characterisation of Crohn's disease fistulae","volume":"53","author":"Bataille","year":"2004","journal-title":"Gut"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0105","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1002\/ibd.20590","article-title":"Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease","volume":"14","author":"Bataille","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0110","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.3748\/wjg.14.2662","article-title":"Colorectal cancer and dysplasia in inflammatory bowel disease","volume":"14","author":"Zisman","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0115","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1463-1318.2003.00510.x","article-title":"Anal and rectal cancer in Crohn's disease","volume":"5","author":"Sjodahl","year":"2003","journal-title":"Colorectal Dis"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0120","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s10350-008-9294-4","article-title":"Fistula-associated anal adenocarcinoma: good results with aggressive therapy","volume":"51","author":"Gaertner","year":"2008","journal-title":"Dis Colon Rectum"},{"key":"10.1097\/PAT.0b013e328340e4d6_bib0125","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0140-6736(10)60353-4","article-title":"Colorectal cancer","volume":"375","author":"Cunningham","year":"2010","journal-title":"Lancet"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516330653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516330653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T15:02:02Z","timestamp":1656082922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302516330653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0031302516330653"],"URL":"https:\/\/doi.org\/10.1097\/pat.0b013e328340e4d6","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}