{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:35:29Z","timestamp":1761896129381},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Oral methanol intoxication is common, but dermal intoxication is rare. We report a previously healthy 19-month-old female infant admitted to the emergency department (ED) with vomiting and tonic-clonic seizure. On physical examination, she was comatose and presented signs of decompensated shock with Kussmaul breathing. Her left thigh was edematous, with purple coloration. Methanol intoxication was suspected due to high anion gap metabolic acidosis (pH, 6.89; HCO<jats:sub>3<\/jats:sub>,  &lt;3 meq\/L) and exposure to spirit-soaked bandages (%96 methanol) for 24 hours and 3 days. The patient's serum methanol level was 20.4 mg\/dL. She was treated with fomepizole and continuous venovenous hemodialysis (CVVHD) in the pediatric intensive care unit, and methanol levels decreased to 0 mg\/dL after 12 hours. During follow-up, massive edema and subarachnoid hemorrhage in the occipital lobe were detected by computed tomography of the brain. The patient died after 7 days.<\/jats:p>\n          <jats:p>Although methanol intoxication occurs predominantly in adults, it must be considered in children with high-anion gap metabolic acidosis. This case report demonstrates that fatal transdermal methanol intoxication can occur in children, and it is the second report in the English literature of transdermal methanol intoxication in an infant.<\/jats:p>","DOI":"10.1097\/pec.0000000000000478","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T16:03:03Z","timestamp":1437494583000},"page":"532-533","source":"Crossref","is-referenced-by-count":3,"title":["A Rare Cause of Metabolic Acidosis"],"prefix":"10.1097","volume":"32","author":[{"given":"Zumrut","family":"Sahbudak Bal","sequence":"first","affiliation":[{"name":"From the *Department of Pediatric Infectious Disease, Medical School of Ege University; \u2020Department of Pediatric Intensive Care, \u2021Department of Pediatric Emergency Care, and \u00a7Department of Pediatric Nephrology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulya Kamit","family":"Can","sequence":"additional","affiliation":[{"name":"From the *Department of Pediatric Infectious Disease, Medical School of Ege University; \u2020Department of Pediatric Intensive Care, \u2021Department of Pediatric Emergency Care, and \u00a7Department of Pediatric Nephrology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Berna","family":"Anil","sequence":"additional","affiliation":[{"name":"From the *Department of Pediatric Infectious Disease, Medical School of Ege University; \u2020Department of Pediatric Intensive Care, \u2021Department of Pediatric Emergency Care, and \u00a7Department of Pediatric Nephrology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkan","family":"Bal","sequence":"additional","affiliation":[{"name":"From the *Department of Pediatric Infectious Disease, Medical School of Ege University; \u2020Department of Pediatric Intensive Care, \u2021Department of Pediatric Emergency Care, and \u00a7Department of Pediatric Nephrology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Anil","sequence":"additional","affiliation":[{"name":"From the *Department of Pediatric Infectious Disease, Medical School of Ege University; \u2020Department of Pediatric Intensive Care, \u2021Department of Pediatric Emergency Care, and \u00a7Department of Pediatric Nephrology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"Gokalp","sequence":"additional","affiliation":[{"name":"From the *Department of Pediatric Infectious Disease, Medical School of Ege University; \u2020Department of Pediatric Intensive Care, \u2021Department of Pediatric Emergency Care, and \u00a7Department of Pediatric Nephrology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onder","family":"Yavascan","sequence":"additional","affiliation":[{"name":"From the *Department of Pediatric Infectious Disease, Medical School of Ege University; \u2020Department of Pediatric Intensive Care, \u2021Department of Pediatric Emergency Care, and \u00a7Department of Pediatric Nephrology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nejat","family":"Aksu","sequence":"additional","affiliation":[{"name":"From the *Department of Pediatric Infectious Disease, Medical School of Ege University; \u2020Department of Pediatric Intensive Care, \u2021Department of Pediatric Emergency Care, and \u00a7Department of Pediatric Nephrology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20231023","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1081\/CLT-120006745","article-title":"American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning","volume":"40","year":"2002","journal-title":"J Toxicol Clin Toxicol"},{"key":"bib2-20231023","first-page":"1504","article-title":"Bilateral basal ganglionic lesions due to transdermal methanol intoxication","volume":"6","year":"2009","journal-title":"J Clin Neurosci"},{"key":"bib3-20231023","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0022-3476(79)80176-6","article-title":"Methyl alcohol poisoning in an 8-month-old boy: an unusual route of intoxication","volume":"94","year":"1979","journal-title":"J Pediatr"},{"key":"bib4-20231023","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/0974-9233.106406","article-title":"Bilateral total optic atrophy due to transdermal methanol intoxication","volume":"20","year":"2013","journal-title":"Middle East Afr J Ophthalmol"},{"key":"bib5-20231023","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1399-6576.2007.01332.x","article-title":"Transdermal methanol intoxication: a case report","volume":"51","year":"2007","journal-title":"Acta Anaesthesiol Scand"},{"key":"bib6-20231023","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/jat\/29.7.734","article-title":"Percutaneous absorption and distribution of methanol in a homicide","volume":"29","year":"2005","journal-title":"J Anal Toxicol"},{"key":"bib7-20231023","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/0960327106080077","article-title":"Prognostic factors in methanol poisoning","volume":"26","year":"2007","journal-title":"Hum Exp Toxicol"},{"key":"bib8-20231023","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/MAJ.0b013e3181c94601","article-title":"Ethylene glycol, methanol and isopropyl alcohol intoxication","volume":"339","year":"2010","journal-title":"Am J Med Sci"},{"key":"bib10-20231023","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-227X-10-3","article-title":"Accidental methanol ingestion: case report","volume":"10","year":"2010","journal-title":"BMC Emerg Med"},{"key":"bib11-20231023","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1056\/NEJMct0806112","article-title":"Fomepizole for ethylene glycol and methanol poisoning","volume":"360","year":"2009","journal-title":"N Engl J Med"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00006565-201608000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:02:15Z","timestamp":1698026535000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006565-201608000-00008"}},"subtitle":["Fatal Transdermal Methanol Intoxication in an Infant"],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000000478","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"value":"1535-1815","type":"electronic"},{"value":"0749-5161","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}