{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:09:16Z","timestamp":1760044156866},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>A 22-month-old girl without any significant medical history accidentally consumed a small amount of a therapeutic compounding cream that contained camphor, gabapentin, clonidine, ketoprofen, and lidocaine. Upon presentation to the emergency department, the child exhibited immediate onset of altered mental status with wide fluctuation in her vital signs, which included intermittent apnea requiring bag-valve mask assistance and endotracheal intubation. Serum laboratory analysis measured a clonidine level of 2.6 ng\/mL and undetectable camphor, gabapentin, and ketoprofen levels. While on mechanical ventilation, the patient exhibited hypothermia, bradycardia, and hypotension; all of which responded to supportive care. After approximately 12 hours in the intensive care unit, the patient was successfully extubated and remained asymptomatic. This unique case of a patient with brief, unintentional oral exposure to a compounding cream, who demonstrated severe toxicity despite only a measured, supratherapeutic clonidine concentration, is discussed. Emergency physicians and pediatricians should be alert to the potential for exposure of pediatric patients to these medicinal compounds. Furthermore, parents must be made aware of the potential dangers of compounded medications and ensure their proper usage and storage.<\/jats:p>","DOI":"10.1097\/pec.0000000000000790","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T02:16:06Z","timestamp":1469240166000},"page":"e79-e81","source":"Crossref","is-referenced-by-count":7,"title":["Clonidine Overdose in a Toddler Due to Accidental Ingestion of a Compounding Cream"],"prefix":"10.1097","volume":"34","author":[{"given":"Alexis L.","family":"Cates","sequence":"first","affiliation":[{"name":"From the *William Carey University College of Osteopathic Medicine, Hattiesburg, MS; and Departments of \u2020Pediatric Medicine and \u2021Emergency Medicine, Lehigh Valley Health Network, Allentown, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott M.","family":"Wheatley","sequence":"additional","affiliation":[{"name":"From the *William Carey University College of Osteopathic Medicine, Hattiesburg, MS; and Departments of \u2020Pediatric Medicine and \u2021Emergency Medicine, Lehigh Valley Health Network, Allentown, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Katz","sequence":"additional","affiliation":[{"name":"From the *William Carey University College of Osteopathic Medicine, Hattiesburg, MS; and Departments of \u2020Pediatric Medicine and \u2021Emergency Medicine, Lehigh Valley Health Network, Allentown, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib2-20231023","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pain.2004.07.020","article-title":"Topical clonidine antinociception","volume":"111","year":"2004","journal-title":"Pain"},{"key":"bib3-20231023","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s13181-013-0331-x","article-title":"Dermal exposure to a compounded pain cream resulting in severely elevated clonidine concentration","volume":"10","year":"2014","journal-title":"J Med Toxicol"},{"key":"bib4-20231023","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1097\/PEC.0b013e3182aa4748","article-title":"Compounded ointment results in severe toxicity in a pediatric patient","volume":"29","year":"2013","journal-title":"Pediatr Emerg Care"},{"key":"bib5-20231023","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1542\/peds.2008-2097","article-title":"A cluster of children with seizures caused by camphor poisoning","volume":"123","year":"2009","journal-title":"Pediatrics"},{"key":"bib6-20231023","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jemermed.2004.02.010","article-title":"Are one or two dangerous? 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