{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T17:42:08Z","timestamp":1748886128390},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Skin and soft tissue infections (SSTIs) are a common reason for presentation to the emergency department (ED) and account for 3% of ED visits. Patients with a diagnosis of cellulitis requiring intravenous (IV) antibiotics have traditionally been admitted to the hospital. In our institution, these patients are placed in the ED Observation Unit (EDOU) for IV antibiotics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>The purpose of this study is to determine if 3 doses of IV antibiotics are adequate to document clinical improvement in children with uncomplicated SSTI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A prospective cohort study of children aged 3 months to 18 years with uncomplicated SSTI admitted (2009\u20132013) to the EDOU at a children's hospital for IV antibiotics was conducted.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>One hundred six patients (mean age, 68 months) were enrolled; 57% were boys, 53% of patients had cellulitis only and 47% had cellulitis with drained abscesses. There was a significant decrease in pain scores and size of cellulitis from arrival to discharge (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001 and <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001, respectively). Eighty-three percent of patients were discharged after 3 to 4 doses of antibiotics, and 17% were admitted. The location of the wound, presence of systemic symptoms, and prior use of oral antibiotics did not predict admission in our study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The EDOU is a reasonable alternative to inpatient admission in the management of patients with uncomplicated SSTI requiring IV antibiotics.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000000975","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T17:02:26Z","timestamp":1480525346000},"page":"204-208","source":"Crossref","is-referenced-by-count":6,"title":["Managing Skin and Soft Tissue Infections in the Emergency Department Observation Unit"],"prefix":"10.1097","volume":"35","author":[{"given":"Shabana","family":"Yusuf","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatrics Emergency Medicine, Baylor College of Medicine and Texas Children's Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Hagan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Newborn Center, Houston, TX."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aderonke O.","family":"Adekunle-Ojo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatrics Emergency Medicine, Baylor College of Medicine and Texas Children's Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20230930","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.annemergmed.2007.12.004","article-title":"Increased US Emergency Department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus","volume":"51","year":"2008","journal-title":"Ann Emerg Med"},{"key":"bib2-20230930","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.annemergmed.2007.12.005","article-title":"MRSA: deadly super bug or just another staph?","volume":"51","year":"2008","journal-title":"Ann Emerg Med"},{"key":"bib3-20230930","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/INF.0b013e31815819bb","article-title":"A review of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections","volume":"27","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"bib4-20230930","doi-asserted-by":"crossref","first-page":"e959","DOI":"10.1542\/peds.2008-2428","article-title":"Empiric antimicrobial therapy for pediatric skin and soft-tissue infections in the era of methicillin-resistant Staphylococcus aureus","volume":"123","year":"2009","journal-title":"Pediatrics"},{"key":"bib5-20230930","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1001\/archpedi.159.10.980","article-title":"Epidemic of community-acquired methicillin-resistant Staphylococcus aureus infections: a 14-year study at Driscoll Children's Hospital","volume":"159","year":"2005","journal-title":"Arch Pediatr Adolesc Med"},{"key":"bib6-20230930","doi-asserted-by":"crossref","first-page":"e718","DOI":"10.1542\/peds.2012-0746","article-title":"Trends in resource utilization for hospitalized children with skin and soft tissue infections","volume":"131","year":"2013","journal-title":"Pediatrics"},{"key":"bib7-20230930","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0733-8627(05)70178-4","article-title":"Pediatric observation medicine","volume":"19","year":"2001","journal-title":"Emerg Med Clin North Am"},{"key":"bib8-20230930","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1542\/peds.2012-1358","article-title":"Pediatric observation units","volume":"130","year":"2012","journal-title":"Pediatrics"},{"key":"bib9-20230930","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1542\/peds.2004-0391","article-title":"The pediatric hybrid observation unit: an analysis of 6477 consecutive patient encounters","volume":"115","year":"2005","journal-title":"Pediatrics"},{"key":"bib10-20230930","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1056\/NEJMclde0708359","article-title":"Clinical decisions. 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