{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:58:48Z","timestamp":1788803928142,"version":"build-2803163510"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute pain is one of the major complaints reported in pediatric emergency departments and general wards. Recently, both the US Food and Drug Administration and European Medicine Agency emitted some warnings regarding the use of opioids, including codeine, in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aims of this study were summarizing the main pharmacological aspects of ibuprofen, discussing the current evidence about the use of ibuprofen in different and specific clinical settings, and providing a comparison with acetaminophen and\/or codeine, according to available studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Studies evaluating ibuprofen for the management of acute pain in children were extracted from the PubMed and MEDLINE database within the period ranging from 1985 through 2017. After discussing safety of ibuprofen and its concomitant use with acetaminophen, the specific indications for the clinical practice were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ibuprofen resulted to be more effective than acetaminophen, and comparable to the combination acetaminophen-codeine, for the control of acute pain related to musculoskeletal pain. Moreover, similar results have been reported also in the management of toothache and inflammatory diseases of the oral cavity and pharynx. Ibuprofen resulted to be useful as a first approach to episodic headache. Finally, the role of ibuprofen in the management of postoperative pain and, particularly, after tonsillectomy and\/or adenoidectomy has been reconsidered recently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ibuprofen resulted to be the most studied nonsteroidal anti-inflammatory drug in the management of acute pain in children; in general, it showed a good safety profile and provided evidence of effectiveness, despite some differences according to the specific clinical context.<\/jats:p><\/jats:sec>","DOI":"10.1097\/pec.0000000000001505","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:20:23Z","timestamp":1529022023000},"page":"448-453","source":"Crossref","is-referenced-by-count":38,"title":["Ibuprofen for Pain Control in Children"],"prefix":"10.1097","volume":"35","author":[{"given":"Dimitri","family":"Poddighe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Licari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luigi","family":"Marseglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"key":"bib2-20230930","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.spen.2016.10.001","article-title":"Pediatric pain measurement, assessment, and evaluation","volume":"23","year":"2016","journal-title":"Semin Pediatr Neurol"},{"key":"bib3-20230930","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/BF03261998","article-title":"Balancing the risks and benefits of the use of over-the-counter pain medications in children","volume":"35","year":"2012","journal-title":"Drug Saf"},{"key":"bib4-20230930","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2165\/00128072-200103110-00004","article-title":"Risks and benefits of nonsteroidal anti-inflammatory drugs in children: a comparison with paracetamol","volume":"3","year":"2001","journal-title":"Paediatr Drugs"},{"key":"bib5-20230930","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/archdischild-2014-307286","article-title":"Codeine in paediatrics: pharmacology, prescribing and controversies","volume":"101","year":"2016","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"bib6-20230930","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10787-009-0016-x","article-title":"Ibuprofen: pharmacology, efficacy and safety","volume":"17","year":"2009","journal-title":"Inflammopharmacology"},{"key":"bib7-20230930","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1185\/03007990903116255","article-title":"Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever","volume":"25","year":"2009","journal-title":"Curr Med Res Opin"},{"key":"bib8-20230930","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s40265-017-0751-z","article-title":"Working towards an appropriate use of ibuprofen in children: an evidence-based appraisal","volume":"77","year":"2017","journal-title":"Drugs"},{"key":"bib9-20230930","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jama.1995.03520360043037","article-title":"An assessment of the safety of pediatric ibuprofen. 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