{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:08:59Z","timestamp":1788476939628,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Chikungunya (CHIKV) is an emerging arboviral infection with recent spikes in transmission in the Americas. Chikungunya is most commonly transmitted by mosquitos, specifically <jats:italic toggle=\"yes\">Aedes aegypti<\/jats:italic> and <jats:italic toggle=\"yes\">Aedes albopictus<\/jats:italic>. These mosquitoes are found throughout many parts of the United States. The classic tetrad of symptoms for CHIKV is fever, symmetric polyarthralgia, maculopapular rash, and nonpurulent conjunctivitis. Although the majority (3 of 4) of infected people will be symptomatic, the viral illness generally runs a benign course. Nevertheless, when compared with infected adults, children more commonly have neurological and dermatological symptoms and are less likely to have arthralgia. The key differential diagnosis to consider is dengue, which has greater immediate morbidity and which can cause coinfection. Local health departments facilitate diagnostic testing, using either RNA polymerase chain reaction or antibody screening based on the timing of presentation. Management is supportive. The purpose of this review article is to provide readers basic knowledge regarding the microbiology, epidemiology, risk factors for transmission, and typical clinical presentation of CHIKV. A practical approach to diagnosis and management of infected children is provided.<\/jats:p>","DOI":"10.1097\/pec.0000000000001529","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T05:04:29Z","timestamp":1530335069000},"page":"510-515","source":"Crossref","is-referenced-by-count":35,"title":["Chikungunya in Children"],"prefix":"10.1097","volume":"34","author":[{"given":"Caleb E.","family":"Ward","sequence":"first","affiliation":[{"name":"Pediatric Emergency Medicine Fellow (Ward), and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer I.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Assistant Professor of Pediatrics (Chapman), Division of Pediatric Emergency Medicine, Department of Pediatrics, Children's National Health System, George Washington University School of Medicine and Health Sciences, Washington DC."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"bib1-20230930","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1749-6632.2001.tb02681.x","article-title":"Human arbovirus infections worldwide","volume":"951","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"bib2-20230930","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1099\/vir.0.82858-0","article-title":"Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus","volume":"88","year":"2007","journal-title":"J Gen Virol"},{"key":"bib3-20230930","first-page":"28","article-title":"An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. 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