{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:37:16Z","timestamp":1761676636456},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Lyme disease is the most common vector-borne illness in North America, with the majority of cases occurring in the Northeast and upper Midwest. Lyme arthritis is the most prevalent manifestation of late-stage Lyme disease. Lyme arthritis typically presents as a monoarthritis or oligoarthritis in large joints such as the knee. Accompanying positive 2-tier Lyme serologies or polymerase chain reaction from synovial fluid\/tissue is considered diagnostic for patients from an endemic area. The mainstay of initial treatment is a prolonged course of oral antibiotics.<\/jats:p>","DOI":"10.1097\/pec.0000000000001576","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T22:39:50Z","timestamp":1533335990000},"page":"588-591","source":"Crossref","is-referenced-by-count":11,"title":["Lyme Arthritis"],"prefix":"10.1097","volume":"34","author":[{"given":"Katharine Christina","family":"Long","sequence":"first","affiliation":[{"name":"Academic Chief of Emergency Department Education, Valley Children's Hospital, Clovis; and Clinical Instructor (Affiliate) of Emergency Department, Stanford University School of Medicine, Stanford, CA (Long); and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keri Anne","family":"Cohn","sequence":"additional","affiliation":[{"name":"Assistant Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; and Director of Pediatric Emergency Medicine\u2013Global Health Fellowship (Cohn), The Children's Hospital of Philadelphia, Philadelphia, PA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20230930","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/0003-4819-107-5-725","article-title":"The clinical evolution of Lyme arthritis","volume":"107","year":"1987","journal-title":"Ann Intern Med"},{"key":"bib2-20230930","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.7043737","article-title":"Lyme disease\u2014a tick-borne spirochetosis?","volume":"216","year":"1982","journal-title":"Science"},{"key":"bib4-20230930","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cll.2010.01.003","article-title":"Lyme Disease","volume":"30","year":"2010","journal-title":"Clin Lab Med"},{"key":"bib5-20230930","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1126\/science.8503006","article-title":"The biological and social phenomenon of Lyme disease","volume":"260","year":"1993","journal-title":"Science"},{"key":"bib6-20230930","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4269\/ajtmh.13-0180","article-title":"Meteorological influences on the seasonality of Lyme disease in the United States","volume":"90","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"bib7-20230930","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/01241398-198709000-00005","article-title":"Musculoskeletal manifestations of Lyme disease in children","volume":"7","year":"1987","journal-title":"J Pediatr Orthop"},{"key":"bib8-20230930","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-3476(86)80688-6","article-title":"Childhood Lyme arthritis: experience in an endemic area","volume":"109","year":"1986","journal-title":"J Pediatr"},{"issue":"4 pt 1","key":"bib9-20230930","first-page":"905","article-title":"Lyme arthritis in children: clinical epidemiology and long-term outcomes","volume":"102","year":"1998","journal-title":"Pediatrics"},{"key":"bib10-20230930","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/01241398-200301000-00023","article-title":"Lyme arthritis presenting as acute septic arthritis in children","volume":"23","year":"2003","journal-title":"J Pediatr Orthop"},{"key":"bib11-20230930","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2106\/00004623-198769010-00016","article-title":"Lyme arthritis in children: an orthopaedic perspective","volume":"69","year":"1987","journal-title":"J Bone Joint Surg Am"},{"key":"bib12-20230930","first-page":"982","article-title":"Notes from the field: update on Lyme carditis, groups at high risk, and frequency of associated sudden cardiac death\u2014United States","volume":"63","year":"2014","journal-title":"MMWR"},{"key":"bib13-20230930","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jemermed.2017.01.022","article-title":"Lyme disease: emergency department considerations","volume":"52","year":"2017","journal-title":"J Emerg Med"},{"key":"bib14-20230930","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1542\/peds.2011-1215","article-title":"Validation of a clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis","volume":"129","year":"2012","journal-title":"Pediatrics"},{"key":"bib15-20230930","doi-asserted-by":"crossref","first-page":"e695","DOI":"10.1542\/peds.2012-2531","article-title":"Distinguishing Lyme from septic knee monoarthritis in Lyme disease\u2013endemic areas","volume":"131","year":"2013","journal-title":"Pediatrics"},{"key":"bib16-20230930","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2106\/JBJS.14.01331","article-title":"Predictive factors for differentiating between septic arthritis and Lyme disease of the knee in children","volume":"98","year":"2016","journal-title":"J Bone Joint Surg Am"},{"key":"bib17-20230930","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0002-9343(85)90432-2","article-title":"Diagnosing early Lyme disease","volume":"78","year":"1985","journal-title":"Am J Med"},{"key":"bib18-20230930","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/infdis\/149.5.789","article-title":"Antibody response in Lyme disease: evaluation of diagnostic tests","volume":"149","year":"1984","journal-title":"J Infect Dis"},{"key":"bib19-20230930","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1002\/art.22131","article-title":"Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis","volume":"54","year":"2006","journal-title":"Arthritis Rheum"},{"key":"bib20-20230930","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1086\/322669","article-title":"Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10\u201320 years after active Lyme disease","volume":"33","year":"2001","journal-title":"Clin Infect Dis"},{"key":"bib21-20230930","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1542\/peds.2008-1511","article-title":"Acute pediatric monoarticular arthritis: distinguishing Lyme arthritis from other etiologies","volume":"123","year":"2009","journal-title":"Pediatrics"},{"key":"bib22-20230930","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.idc.2007.12.014","article-title":"Lyme arthritis: pathogenesis, clinical presentation, and management","volume":"22","year":"2008","journal-title":"Infect Dis Clin North Am"},{"key":"bib23-20230930","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1002\/art.30384","article-title":"Burden and viability of Borrelia burgdorferi in skin and joints of patients with erythema migrans or Lyme arthritis","volume":"63","year":"2011","journal-title":"Arthritis Rheum"},{"key":"bib24-20230930","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.idc.2015.02.004","article-title":"Diagnosis and treatment of Lyme arthritis","volume":"29","year":"2015","journal-title":"Infect Dis Clin North Am"},{"key":"bib25-20230930","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM199401273300401","article-title":"Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis","volume":"330","year":"1994","journal-title":"N Engl J Med"},{"key":"bib27-20230930","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00508-005-0361-8","article-title":"A comparison of two treatment regimens of ceftriaxone in late Lyme disease","volume":"117","year":"2005","journal-title":"Wien Klin Wochenschr"},{"key":"bib28-20230930","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/art.1780370616","article-title":"Treatment of Lyme arthritis","volume":"37","year":"1994","journal-title":"Arthritis Rheum"},{"key":"bib29-20230930","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jpeds.2015.02.015","article-title":"No visible dental staining in children treated with doxycycline for suspected Rocky Mountain spotted fever","volume":"166","year":"2015","journal-title":"J Pediatr"},{"key":"bib30-20230930","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/508667","article-title":"The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"43","year":"2006","journal-title":"Clin Infect Dis"},{"key":"bib31-20230930","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1128\/IAI.69.3.1774-1780.2001","article-title":"Expression of adhesion molecules in synovia of patients with treatment-resistant Lyme arthritis","volume":"69","year":"2001","journal-title":"Infect Immun"},{"key":"bib32-20230930","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/art.1780310405","article-title":"Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis: comparison with rheumatoid synovium and tonsillar lymphoid tissue","volume":"31","year":"1988","journal-title":"Arthritis Rheum"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00006565-201808000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T08:13:52Z","timestamp":1696061632000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006565-201808000-00011"}},"subtitle":["An Update for Clinical Practice"],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000001576","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"value":"1535-1815","type":"electronic"},{"value":"0749-5161","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}