{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:04:07Z","timestamp":1772600647907,"version":"3.50.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>Despite the favorable data concerning topical agents use in outpatient clinics, they are not commonly in emergency departments (EDs). The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in children presenting with ankle sprain to the ED.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Study Design<\/jats:title>\n            <jats:p>Children between 7 and 18 years old presenting with ankle sprain composed the study population. Study patients were randomized into 2 study arms: 2.5% ketoprofen gel and placebo administered in a 5-cm area locally. Pain improvements at 15 and 30 minutes were measured by visual analog scale.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Median pain reductions at 15 minutes for ketoprofen and placebo groups were 27.5 (16\u201339) and 5 (4\u201310), respectively. Median changes in pain intensity at 30 minutes for ketoprofen and placebo gel groups were 48 (43\u201352) and 9 (6\u201316), respectively. When compared 2 arms for the pain improvement at 15 and 30 minutes, the differences between 2 study drugs were 20 (13\u201328) and 35 (29\u201341), respectively. There were 7 (12.7%) rescue drug needs in the placebo group and 1 (1.7%) in the ketoprofen group (difference, 10.9%; 95% confidence interval, \u22126% to 7%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.83). There were no adverse effects in either group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Ketoprofen gel is superior to placebo in ceasing pain in children presenting with ankle sprain to the ED with a high safety profile.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000001595","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T22:12:14Z","timestamp":1540591934000},"page":"e447-e450","source":"Crossref","is-referenced-by-count":7,"title":["Topical Ketoprofen Versus Placebo in Children Presenting With Ankle Sprain to the Emergency Department"],"prefix":"10.1097","volume":"36","author":[{"given":"Mustafa","family":"Serinken","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Pamukkale University Medical Faculty, Denizli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cenker","family":"Eken","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Akdeniz University Medical Faculty, Antalya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"T\u00fcnay","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kocatepe University Medical Faculty, Afyonkarahisar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalcin","family":"G\u00f6lc\u00fck","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Manisa Celal Bayar University Medical Faculty, Manisa, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"bib1-20230930","doi-asserted-by":"crossref","first-page":"e154147","DOI":"10.1001\/jamapediatrics.2015.4147","article-title":"Revisiting radiograph-negative ankle injuries in children: is it a fracture or a sprain?","volume":"170","year":"2016","journal-title":"JAMA Pediatr"},{"key":"bib2-20230930","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1185\/030079908X273066","article-title":"Topical diclofenac and its role in pain and inflammation: an evidence-based review","volume":"24","year":"2008","journal-title":"Curr Med Res Opin"},{"key":"bib3-20230930","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3810\/psm.2010.06.1784","article-title":"Update on the use of topical NSAIDs for the treatment of soft tissue and musculoskeletal pain: a review of recent data and current treatment options","volume":"38","year":"2010","journal-title":"Phys Sportsmed"},{"key":"bib4-20230930","article-title":"Ankle sprain: the effects of non-steroidal anti-inflammatory drugs","volume":"2015","year":"2015","journal-title":"BMJ Clin 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Sci"},{"key":"bib9-20230930","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1056\/NEJMsa1406143","article-title":"Trends in opioid analgesic abuse and mortality in the United States","volume":"372","year":"2015","journal-title":"N Engl J Med"},{"key":"bib10-20230930","article-title":"Topical ketoprofen versus placebo in treatment of acute ankle sprain in the emergency department [published online ahead of print May 19, 2016]","year":"2016","journal-title":"Foot Ankle Int"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000001595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T08:28:57Z","timestamp":1696062537000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000001595"}},"subtitle":["A Randomized Controlled Study"],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000001595","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"value":"1535-1815","type":"electronic"},{"value":"0749-5161","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10,26]]}}}