{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:04:22Z","timestamp":1746417862041,"version":"3.40.4"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Sudden cardiac arrest of cardiac etiology is rare in children and adolescents and most often occurs with exertion. Conversely, syncope is a common pediatric emergency department complaint but rarely is associated with a serious underlying cardiac disorder. This report describes a case of the channelopathy Brugada syndrome (BrS) as a cause of sudden cardiac arrest in a febrile preadolescent child taking medications known to affect cardiac conduction. The patient received cardiopulmonary resuscitation and was successfully defibrillated. Initial electrocardiogram (ECG) demonstrated findings consistent with BrS. Confirmatory electrophysiologic testing was performed, and an implantable cardiac defibrillator was placed. Pediatric emergency specialists must recognize both the importance of ECG in the workup of syncope and be familiar with the specific ECG findings suggestive of BrS. Ventricular arrhythmias that occur at rest should raise the suspicion of this genetic cardiac channelopathy, regardless of age.<\/jats:p>","DOI":"10.1097\/pec.0000000000001640","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T23:55:12Z","timestamp":1539906912000},"page":"e342-e344","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Seizures, Meds, and Vtach"],"prefix":"10.1097","volume":"37","author":[{"given":"David P.","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences, College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikant","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Malone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. Shane","family":"Holland","sequence":"additional","affiliation":[{"name":"Arkansas College of Osteopathic Medicine, Fort Smith, AR."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Schexnayder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"bib1-20250504","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/MOP.0000000000000272","article-title":"Genetics of inherited arrhythmias in pediatrics","volume":"27","year":"2015","journal-title":"Curr Opin Pediatr"},{"key":"bib2-20250504","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cpcardiol.2015.06.002","article-title":"Brugada syndrome: clinical, genetic, molecular, cellular, and ionic aspects","volume":"41","year":"2016","journal-title":"Curr Probl Cardiol"},{"key":"bib3-20250504","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1053\/euhj.1998.1332","article-title":"The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome","volume":"20","year":"1999","journal-title":"Eur Heart J"},{"key":"bib4-20250504","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/hmg\/11.3.337","article-title":"Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome","volume":"11","year":"2002","journal-title":"Hum Mol Genet"},{"key":"bib5-20250504","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1253\/circj.CJ-12-0717","article-title":"Brugada syndrome 2012","volume":"76","year":"2012","journal-title":"Circ J"},{"key":"bib6-20250504","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1161\/CIRCULATIONAHA.106.664219","article-title":"Clinical aspects and prognosis of Brugada syndrome in children","volume":"115","year":"2007","journal-title":"Circulation"},{"key":"bib7-20250504","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1016\/j.hrthm.2013.07.021","article-title":"Executive summary: HRS\/EHRA\/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes","volume":"10","year":"2013","journal-title":"Heart Rhythm"},{"key":"bib8-20250504","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.hrthm.2009.07.002","article-title":"Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)","volume":"6","year":"2009","journal-title":"Heart Rhythm"},{"key":"bib9-20250504","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/CIRCULATIONAHA.113.003077","article-title":"Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype","volume":"129","year":"2014","journal-title":"Circulation"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000001640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T18:08:33Z","timestamp":1746382113000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000001640"}},"subtitle":["A Journey to a Brugada Diagnosis"],"short-title":[],"issued":{"date-parts":[[2018,10,17]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000001640","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"type":"electronic","value":"1535-1815"},{"type":"print","value":"0749-5161"}],"subject":[],"published":{"date-parts":[[2018,10,17]]}}}