{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:44:34Z","timestamp":1756572274433},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2019,12]]},"abstract":"\n Objective<\/jats:title>\n Otitis media, facial pain in trigeminal region, and ipsilateral abducens nerve palsy clinically define Gradenigo syndrome, a rare but serious complication of suppurative middle ear infection. Radiological investigation is required to confirm petrous apex involvement and to exclude further consequences as sinus thrombosis, meningitis, and intracranial abscess.<\/jats:p>\n <\/jats:sec>\n \n Methods\/Results<\/jats:title>\n We report the case of an 8-year-old child referred to our emergency department for recurrent headache and sudden strabismus. Clinical evidence of suppurative otitis media raised the suspicion for Gradenigo syndrome, definitively confirmed at computed tomography and magnetic resonance imaging scans. Conservative treatment alone enabled complete clinical and radiological remission, without long-term sequelae.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Despite being a rare condition, Gradenigo syndrome should be taken into account as potential differential diagnosis in children referred to emergency department for recurrent headache and strabismus. An accurate anamnesis to document recent ear infection is mandatory to orientate the diagnosis and focus radiological investigations. Early recognition and timely intervention may allow conservative management to succeed, avoiding the need for surgery and serious sequelae.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/pec.0000000000001684","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T20:50:55Z","timestamp":1548276655000},"page":"e236-e237","source":"Crossref","is-referenced-by-count":4,"title":["Sudden Diplopia at a Pediatric Emergency Department"],"prefix":"10.1097","volume":"35","author":[{"given":"Alice","family":"Brambilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Pasti","sequence":"additional","affiliation":[{"name":"Ophthalmology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Parri","sequence":"additional","affiliation":[{"name":"Emergency Medicine and Trauma Center, Meyer University Children's Hospital, Florence, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"bib1-20230930","article-title":"Conservative management of Gradenigo's syndrome in a child","volume":"2011","year":"2011","journal-title":"BMJ Case Rep"},{"key":"bib2-20230930","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6815-12-10","article-title":"Mastoiditis and Gradenigo's syndrome with anaerobic bacteria","volume":"12","year":"2012","journal-title":"BMC Ear Nose Throat Disord"},{"key":"bib3-20230930","first-page":"526","article-title":"Gradenigo's syndrome as first presentation of solitary osseous plasmacytoma of the petrous apex","volume":"17","year":"2014","journal-title":"Arch Iran Med"},{"key":"bib4-20230930","article-title":"Embryonic rhabdomyosarcoma presenting as Gradenigo's syndrome","volume":"2012","year":"2012","journal-title":"BMJ Case Rep"},{"key":"bib5-20230930","first-page":"638","article-title":"Gradenigo syndrome as the form of presentation of nasopharyngeal carcinoma","volume":"32","year":"2001","journal-title":"Rev Neurol"},{"key":"bib6-20230930","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000324179","article-title":"Gradenigo's syndrome: beyond the classical triad of diplopia, facial pain and otorrhea","volume":"3","year":"2011","journal-title":"BMJ Case Rep Neurol"},{"key":"bib7-20230930","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1258\/0022215054020313","article-title":"Gradenigo's syndrome: successful conservative treatment in adult and paediatric patients","volume":"119","year":"2005","journal-title":"J Laryngol Otol"},{"key":"bib8-20230930","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1001\/archopht.1989.01070010386029","article-title":"Acute comitant esotropia in children with brain tumors","volume":"107","year":"1989","journal-title":"Arch Ophthalmol"},{"key":"bib9-20230930","first-page":"3","article-title":"Eye signs in 611 cases of posterior fossa aneurysms: their diagnostic and prognostic value","volume":"18","year":"1983","journal-title":"Can J Ophthalmol"},{"key":"bib10-20230930","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.amjoto.2010.07.018","article-title":"Acute otitis media\u2013induced petrous apicitis presenting as the Gradenigo syndrome: successfully treated by ventilation tube insertion","volume":"32","year":"2011","journal-title":"Am J Otolaryngol"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000001684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T08:28:24Z","timestamp":1696062504000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000001684"}},"subtitle":["A Case of Gradenigo Syndrome in a Child"],"short-title":[],"issued":{"date-parts":[[2019,1,23]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000001684","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"value":"1535-1815","type":"electronic"},{"value":"0749-5161","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,23]]}}}