{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:04:21Z","timestamp":1746417861700,"version":"3.40.4"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>Status epilepticus is associated with high rates of morbidity and mortality; thus, early diagnosis and proper treatment are crucial. We aimed to study the etiology, clinical features, and treatment among pediatric patients with convulsive status epilepticus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The medical records of 100 patients were retrospectively obtained from pediatric intensive care unit. Etiology, clinical features, and treatment were interpreted by using Fisher exact test, \u03c7<jats:sup>2<\/jats:sup> test, and Spearman <jats:italic toggle=\"yes\">\u03c1<\/jats:italic> correlation coefficient.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Seizures had stopped with the first-, second-, and third-line treatment in 29%, 36%, and 35% of the patients, respectively. Only phenytoin treatment was efficient; it has 32.3% rate in second-line treatment. Whereas mortality rate was 10%, morbidity rate was 14% during the follow-up. Epilepsy, hemiparesis, spastic tetraparesis, and mental retardation developed. Mortality was significantly much more in the patients with refractory seizure and cerebral palsy. Development of mental retardation was much higher in the male sex.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Phenytoin is still one of the most efficient antiepileptic drugs. If the duration of status epilepticus can be shortened by prompt treatment, neurological complications may be prevented.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000001914","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T07:59:14Z","timestamp":1583740754000},"page":"360-364","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Treatment Outcomes of Pediatric Status Epilepticus in a Tertiary Pediatric Intensive Care Unit"],"prefix":"10.1097","volume":"37","author":[{"given":"Dilek","family":"Cavusoglu","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Faculty of Medicine, Afyon Kocatepe University, Afyon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Esra","family":"S\u0131nmaz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Liv Hospital, Istinye University, Istanbul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal Olgac","family":"Dundar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Tepecik Training and Investigation Hospital, Faculty of Medicine, Izmir Katip Celebi University, Izmir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulya Kamit","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Denizli Public Hospital, Denizli"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Berna","family":"Anil","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Faculty of Medicine, Izmir Katip Celebi University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrak","family":"Sarioglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Tepecik Training and Investigation Hospital, Izmir, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,3,7]]},"reference":[{"key":"bib1-20250504","first-page":"203","article-title":"Convulsive status epilepticus in the pediatric emergency department: five year retrospective analysis","volume":"25","year":"2012","journal-title":"Acta Med Port"},{"key":"bib2-20250504","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0140-6736(06)69043-0","article-title":"Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study","volume":"368","year":"2006","journal-title":"Lancet"},{"key":"bib3-20250504","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1528-1167.2007.01106.x","article-title":"An epidemiological study of children with status epilepticus in Okayama, Japan","volume":"48","year":"2007","journal-title":"Epilepsia"},{"key":"bib4-20250504","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1528-1167.2007.01465.x","article-title":"Aborted and refractory status epilepticus in children: a comparative analysis","volume":"49","year":"2008","journal-title":"Epilepsia"},{"key":"bib5-20250504","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/MOP.0000000000000154","article-title":"Pediatric status epilepticus management","volume":"26","year":"2014","journal-title":"Curr Opin Pediatr"},{"key":"bib6-20250504","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1528-1157.1993.tb00433.x","article-title":"Guidelines for epidemiologic studies on epilepsy: Commission on Epidemiology and Prognosis, International League Against Epilepsy","volume":"34","year":"1993","journal-title":"Epilepsia"},{"key":"bib7-20250504","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12028-012-9695-z","article-title":"Guidelines for the evaluation and management of status epilepticus","volume":"17","year":"2012","journal-title":"Neurocrit Care"},{"key":"bib8-20250504","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0887-8994(95)00044-G","article-title":"Effect of prehospital treatment on the outcome of status epilepticus in children","volume":"12","year":"1995","journal-title":"Pediatr Neurol"},{"key":"bib9-20250504","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/epi.12284","article-title":"Lessons from the RAMPART study\u2014and which is the best route of administration of benzodiazepines in status epilepticus","volume":"54","year":"2013","journal-title":"Epilepsia"},{"key":"bib10-20250504","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.spen.2010.06.005","article-title":"Medical treatment of pediatric status epilepticus","volume":"17","year":"2010","journal-title":"Semin Pediatr Neurol"},{"key":"bib11-20250504","first-page":"CD001905","article-title":"Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"bib12-20250504","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ccc.2012.11.007","article-title":"Pediatric intensive care treatment of uncontrolled status epilepticus","volume":"29","year":"2013","journal-title":"Crit Care Clin"},{"key":"bib13-20250504","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2010.09.003","article-title":"Prognostic factors, morbidity and mortality in tonic-clonic status epilepticus: a review","volume":"93","year":"2011","journal-title":"Epilepsy Res"},{"key":"bib14-20250504","first-page":"21","article-title":"Childhood convulsive status epilepticus: epidemiology, management and outcome","volume":"186","year":"2007","journal-title":"Acta Neurol Scand"},{"key":"bib15-20250504","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1684\/j.1950-6945.2006.tb00278.x","article-title":"Epileptic seizures in the pediatric intensive care unit setting","volume":"8","year":"2006","journal-title":"Epileptic Disord"},{"key":"bib16-20250504","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eplepsyres.2011.05.004","article-title":"An epidemiological study of children with status epilepticus in Okayama, Japan: incidence, etiologies, and outcomes","volume":"96","year":"2011","journal-title":"Epilepsy Res"},{"key":"bib17-20250504","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.pediatrneurol.2009.06.004","article-title":"Analysis of convulsive status epilepticus in children of Taiwan","volume":"41","year":"2009","journal-title":"Pediatr Neurol"},{"key":"bib18-20250504","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.seizure.2009.07.006","article-title":"Analysis of factors influencing admission to intensive care following convulsive status epilepticus in children","volume":"18","year":"2009","journal-title":"Seizure"},{"key":"bib19-20250504","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.yebeh.2005.07.005","article-title":"Etiologies and outcomes of status epilepticus in children","volume":"7","year":"2005","journal-title":"Epilepsy Behav"},{"key":"bib20-20250504","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1212\/WNL.55.5.693","article-title":"Incidence of status epilepticus in French-speaking Switzerland (EPISTAR)","volume":"55","year":"2000","journal-title":"Neurology"},{"key":"bib21-20250504","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.pediatrneurol.2012.03.013","article-title":"Management of patients with status epilepticus treated at a pediatric intensive care unit in Turkey","volume":"46","year":"2012","journal-title":"Pediatr Neurol"},{"key":"bib22-20250504","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1442-200X.2010.03164.x","article-title":"Status epilepticus in children: causes, clinical features and short-term outcome","volume":"52","year":"2010","journal-title":"Pediatr Int"},{"key":"bib23-20250504","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.seizure.2010.10.034","article-title":"Convulsive status epilepticus in children: etiology, treatment protocol and outcome","volume":"20","year":"2011","journal-title":"Seizure"},{"key":"bib24-20250504","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1542\/peds.83.3.323","article-title":"Low morbidity and mortality of status epilepticus in children","volume":"83","year":"1989","journal-title":"Pediatrics"},{"key":"bib25-20250504","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1177\/0883073807306248","article-title":"Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial","volume":"22","year":"2007","journal-title":"J Child Neurol"},{"key":"bib26-20250504","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.seizure.2013.12.007","article-title":"The relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine resistant convulsive status epilepticus: a meta-analysis of published studies","volume":"23","year":"2014","journal-title":"Seizure"},{"key":"bib27-20250504","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/00207454.2012.657376","article-title":"A systematic review of randomized controlled trials on the theraputic effect of intravenous sodium valproate in status epilepticus","volume":"122","year":"2012","journal-title":"Int J Neurosci"},{"key":"bib28-20250504","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1528-1167.2010.02943.x","article-title":"Outcome of status epilepticus in children treated in the intensive care unit: a study of 302 cases","volume":"52","year":"2011","journal-title":"Epilepsia"},{"key":"bib29-20250504","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1528-1167.2006.00870.x","article-title":"Treatment of status epilepticus in adults: guidelines of the Italian League Against Epilepsy","volume":"47","year":"2006","journal-title":"Epilepsia"},{"key":"bib30-20250504","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1177\/0883073815579706","article-title":"Predictors of outcome of convulsive status epilepticus among an Egyptian pediatric tertiary hospital","volume":"30","year":"2015","journal-title":"J Child Neurol"},{"key":"bib31-20250504","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/j.1528-1167.2007.01175.x","article-title":"The epidemiology of convulsive status epilepticus in children: a critical review","volume":"48","year":"2007","journal-title":"Epilepsia"},{"key":"bib32-20250504","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/dmcn.12718","article-title":"Survival with cerebral palsy over five decades in western Sweden","volume":"57","year":"2015","journal-title":"Dev Med Child Neurol"},{"key":"bib33-20250504","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1017\/cjn.2015.307","article-title":"Single center outcomes of status epilepticus at a paediatric intensive care unit","volume":"43","year":"2016","journal-title":"Can J Neurol Sci"},{"key":"bib34-20250504","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/MOP.0000000000000151","article-title":"Continuous electroencephalography for seizures and status epilepticus","volume":"26","year":"2014","journal-title":"Curr Opin Pediatr"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000001914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T18:08:26Z","timestamp":1746382106000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000001914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000001914","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"type":"electronic","value":"1535-1815"},{"type":"print","value":"0749-5161"}],"subject":[],"published":{"date-parts":[[2020,3,7]]}}}