{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T09:19:21Z","timestamp":1696065561436},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>A 29-month-old boy presented to a pediatric emergency department with complaints of trouble sleeping for more than a week. History consisted of episodes of screaming while asleep from which he could not be awakened. A detailed physical examination revealed left arm dystonia and left plantar reflex to be upgoing. Upon admission, all imaging and an electroencephalogram were normal. Extensive laboratory work was done showing positive anti-N-methyl-D-Aspartate (NMDA) antibody in the cerebrospinal fluid. Inpatient care included intravenous immunoglobulin (IVIG) and Solumedrol. Cellcept was started after definitive diagnosis and continued on discharge. The patient was discharged with residual defects that will need long-term therapy. The varied presenting symptoms are easily misinterpreted as common clinical entities. Pediatric emergency physicians need to be aware of the wide spectrum of presenting symptoms for this clinical entity because earlier diagnosis and treatment have been shown to improve long-term morbidity.<\/jats:p>","DOI":"10.1097\/pec.0000000000002253","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T19:07:59Z","timestamp":1600456079000},"page":"e656-e658","source":"Crossref","is-referenced-by-count":0,"title":["Two-Year-Old With Sleep Disturbance and Left Arm Movements"],"prefix":"10.1097","volume":"36","author":[{"given":"James","family":"Sierakowski","sequence":"first","affiliation":[{"name":"Pediatric Emergency Department, College of Medicine, University of Florida Jacksonville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pulin","family":"Koul","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Wolfson Children's Hospital, Jacksonville, FL."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"bib1-20230930","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/cid\/cir1038","article-title":"The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California encephalitis project","volume":"54","year":"2012","journal-title":"Clin Infect Dis"},{"key":"bib2-20230930","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/1742-6723.12015","article-title":"Behavioural disturbance requiring medical referral: a case of anti-N-methyl-D-aspartate receptor encephalitis in the emergency department","volume":"25","year":"2013","journal-title":"Emerg Med Australas"},{"key":"bib3-20230930","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s12098-015-1988-8","article-title":"Childhood anti-NMDA receptor encephalitis","volume":"83","year":"2016","journal-title":"Indian J Pediatr"},{"key":"bib4-20230930","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pedhc.2015.09.004","article-title":"Anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents","volume":"30","year":"2016","journal-title":"J Pediatr Health Care"},{"key":"bib5-20230930","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1017\/S003329171300295X","article-title":"Prevalence of anti-N-methyl-D-aspartate (NMDA) receptor antibodies in patients with schizophrenia and related psychoses: a systematic review and meta-analysis","volume":"44","year":"2014","journal-title":"Psychol Med"},{"key":"bib6-20230930","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(12)70310-1","article-title":"Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study","volume":"12","year":"2013","journal-title":"Lancet Neurol"},{"key":"bib7-20230930","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jca.21363","article-title":"Intravenous methylprednisolone versus therapeutic plasma exchange for treatment of anti-N-methyl-D-aspartate receptor antibody encephalitis: a retrospective review","volume":"30","year":"2015","journal-title":"J Clin Apher"},{"key":"bib8-20230930","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1212\/NXI.0000000000000130","article-title":"Earlier treatment of NMDAR antibody encephalitis in children results in a better outcome","volume":"2","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"bib9-20230930","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/dmcn.12411","article-title":"Does early treatment improve outcomes in N-methyl-D-aspartate receptor encephalitis?","volume":"56","year":"2014","journal-title":"Developmental Medicine and Child Neurology"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T08:30:25Z","timestamp":1696062625000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000002253","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"value":"1535-1815","type":"electronic"},{"value":"0749-5161","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,18]]}}}