{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:27:26Z","timestamp":1762900046922},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>Given the significant overlap of multisystem inflammatory syndrome in children (MIS-C) with other common childhood illnesses presenting to the emergency department, extensive workup of this syndrome has become necessary. Nevertheless, little has been published on the factors differentiating MIS-C from other conditions in the acute care setting. We investigated differences in presentation and laboratory studies between suspected versus confirmed MIS-C patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This was a retrospective cohort study on patients 21 years or younger undergoing investigation for possible MIS-C at a single institution between April 21 and July 1, 2020. The primary outcome was diagnosis of MIS-C or an alternative final diagnosis. Clinical features and laboratory findings from initial presentation were collected and analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 106 patients (median, 4 years; 55.7% male) were included, of whom 17 (16%) of 106 met the criteria for MIS-C. Multisystem inflammatory syndrome in children patients were significantly more likely to report a coronavirus disease 2019 exposure (odds ratio (OR), 13.17 [3.87\u201344.9]), have gastrointestinal symptoms (OR, 3.81 [1.02\u201314.19]), and have a significantly higher odds of having abnormal laboratory values including high-sensitivity troponin T (OR, 13 [4.0\u201342.2]), N-terminal B-type natriuretic peptide (OR, 8.4 [2.3\u201330.1]), D-dimer (OR, 13 [1.6\u2013103]), and ferritin (OR, 7.8 [2.2\u201327.2]). There were also differences between groups in inflammatory markers: C-reactive protein (median, 134.45 mg\/L vs 12.6 mg\/L; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05) and procalcitonin (1.71 ng\/mL vs 0.14 ng\/mL; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Higher elevations in key laboratory studies may help to distinguish between MIS-C patients and non\u2013MIS-C patients presenting to the emergency department.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000002344","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T04:04:27Z","timestamp":1611547467000},"page":"179-184","source":"Crossref","is-referenced-by-count":11,"title":["Distinguishing Features of Patients Evaluated for Multisystem Inflammatory Syndrome in Children"],"prefix":"10.1097","volume":"37","author":[{"given":"Michael S.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil D.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey V.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuella","family":"Lahoud-Rahme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne S.","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"bib1-20230930","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jamapediatrics.2020.1467","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review","volume":"174","year":"2020","journal-title":"JAMA Pediatr"},{"key":"bib2-20230930","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jpids\/piaa069","article-title":"Multisystem inflammatory syndrome in children during the coronavirus 2019 pandemic: a case series","volume":"9","year":"2020","journal-title":"J Pediatric Infect Dis Soc"},{"key":"bib3-20230930","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13613-020-00690-8","article-title":"Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children","volume":"10","year":"2020","journal-title":"Ann Intensive Care"},{"key":"bib4-20230930","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","article-title":"Hyperinflammatory shock in children during COVID-19 pandemic","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"bib5-20230930","first-page":"m2094","article-title":"Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study","volume":"369","year":"2020","journal-title":"BMJ"},{"key":"bib6-20230930","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study","volume":"395","year":"2020","journal-title":"Lancet"},{"key":"bib7-20230930","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/jama.2020.10369","article-title":"Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2","volume":"324","year":"2020","journal-title":"JAMA"},{"key":"bib8-20230930","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJMoa2021756","article-title":"Multisystem inflammatory syndrome in children in New York State","volume":"383","year":"2020","journal-title":"N Engl J Med"},{"key":"bib9-20230930","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem inflammatory syndrome in U.S. children and adolescents","volume":"383","year":"2020","journal-title":"N Engl J Med"},{"key":"bib10-20230930","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.echo.2020.08.008","article-title":"Multisystem inflammatory syndrome in children (MIS-C): cardiac biomarker profiles and echocardiographic findings in the acute and recovery phases","volume":"33","year":"2020","journal-title":"J Am Soc Echocardiogr"},{"key":"bib13-20230930","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.15585\/mmwr.mm6932e2","article-title":"COVID-19\u2013associated multisystem inflammatory syndrome in children \u2014 United States, March\u2013July 2020","volume":"69","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bib15-20230930","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1056\/NEJMcp1009126","article-title":"Streptococcal pharyngitis","volume":"364","year":"2011","journal-title":"N Engl J Med"},{"key":"bib16-20230930","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/bmj.39036.406169.80","article-title":"Acute gastroenteritis in children","volume":"334","year":"2007","journal-title":"Br Med J"},{"key":"bib17-20230930","article-title":"Discriminating MIS-C requiring treatment from common febrile conditions in outpatient settings","year":"2020","journal-title":"J Pediatr"},{"key":"bib18-20230930","first-page":"3","article-title":"Kawasaki disease features and myocarditis in a patient with COVID-19","volume":"1","year":"2020","journal-title":"Pediatr Cardiol"},{"key":"bib20-20230930","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","year":"2009","journal-title":"J Biomed Inform"},{"key":"bib21-20230930","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","year":"2019","journal-title":"J Biomed Inform"},{"key":"bib23-20230930","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3414\/ME15-04-0007","article-title":"Youden's index and the weight of evidence revisited","volume":"54","year":"2015","journal-title":"Methods Inf Med"},{"key":"bib24-20230930","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","year":"1950","journal-title":"Cancer"},{"key":"bib25-20230930","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13312-011-0055-4","article-title":"Receiver operating characteristic (ROC) curve for medical researchers","volume":"48","year":"2011","journal-title":"Indian Pediatr"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T08:27:34Z","timestamp":1696062454000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,25]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000002344","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"value":"1535-1815","type":"electronic"},{"value":"0749-5161","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,25]]}}}