{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:40:08Z","timestamp":1746391208711,"version":"3.40.4"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>We aimed to describe a case of prematurely born infant with accidental sildenafil overdose.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This was a retrospective case report followed with chart and literature review.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Main Findings<\/jats:title>\n            <jats:p>A prematurely born infant with moderate bronchopulmonary dysplasia, corrected congenital heart disease, and pulmonary hypertension presented with an accidental sildenafil overdose. Despite the relatively high dose in this medically frail infant and the long elimination half-life of sildenafil in infants, the symptoms of sildenafil overdose in our patient were only mild. After a short and uneventful period of observation in the hospital, the patient was discharged home.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Sildenafil overdose can cause serious symptoms such as hypotension. However, in our case, the sildenafil overdose was well tolerated, even by a young patient with underlying heart and lung disease. We show that choices in the management of sildenafil intoxication can be made based on the knowledge of sildenafil pharmacokinetics in young children.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000002472","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T19:13:49Z","timestamp":1623179629000},"page":"e866-e867","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Sildenafil Citrate Overdose in a 3-Month Postterm Premature Infant With Pulmonary Artery Hypertension"],"prefix":"10.1097","volume":"37","author":[{"given":"Marjolein","family":"van Heugten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lonneke","family":"van Onzenoort-Bokken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"bib2-20250504","doi-asserted-by":"crossref","first-page":"851.e1","DOI":"10.1016\/j.ahj.2005.09.006","article-title":"A randomized, placebo-controlled, double-blind, crossover study to evaluate the efficacy of oral sildenafil therapy in severe pulmonary artery hypertension","volume":"151","year":"2006","journal-title":"Am Heart J"},{"key":"bib4-20250504","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000097125","article-title":"Cardiovascular effects of sildenafil in neonates and infants with congenital diaphragmatic hernia and pulmonary hypertension","volume":"91","year":"2007","journal-title":"Neonatology"},{"key":"bib6-20250504","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00246-009-9523-1","article-title":"Sildenafil for the treatment of pulmonary hypertension in pediatric patients","volume":"30","year":"2009","journal-title":"Pediatr Cardiol"},{"key":"bib7-20250504","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1081\/CLT-100105168","article-title":"Sildenafil overdose in a female patient","volume":"39","year":"2001","journal-title":"J Toxicol Clin Toxicol"},{"key":"bib8-20250504","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1080\/15563650701664483","article-title":"Sildenafil citrate ingestion and prolonged priapism and tachycardia in a pediatric patient","volume":"45","year":"2007","journal-title":"Clin Toxicol (Phila)"},{"key":"bib9-20250504","first-page":"314","article-title":"Sildenafil citrate ingestion in a pediatric patient","volume":"20","year":"2004","journal-title":"Pediatr Emerg Care"},{"key":"bib10-20250504","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/clpt.2008.177","volume":"85","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"bib12-20250504","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/0885066608321389","article-title":"Use of sildenafil to facilitate weaning from inhaled nitric oxide in children with pulmonary hypertension following surgery for congenital heart disease","volume":"23","year":"2008","journal-title":"J Intensive Care Med"},{"key":"bib13-20250504","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s12519-017-0043-4","article-title":"Pharmacokinetics of sildenafil in children with pulmonary arterial hypertension","volume":"13","year":"2017","journal-title":"World J Pediatr"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:04:49Z","timestamp":1746389089000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000002472","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"type":"electronic","value":"1535-1815"},{"type":"print","value":"0749-5161"}],"subject":[],"published":{"date-parts":[[2021,6,8]]}}}