{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:05:01Z","timestamp":1785153901386,"version":"3.55.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Staphylococcal scalded skin syndrome is a superficial blistering disorder caused by exfoliative toxin-releasing strains of <jats:italic toggle=\"yes\">Staphylococcus aureus.<\/jats:italic> Bacterial toxins are released hematogenously, and after a prodromal fever and exquisite tenderness of skin, patients present with tender erythroderma and flaccid bullae with subsequent superficial generalized exfoliation. The head-to-toe directed exfoliation lasts up to 10 to 14 days without scarring after proper treatment. Children younger than 6 years are predominantly affected because of their lack of toxin-neutralizing antibodies and the immature renal system's inability to excrete the causative exotoxins. The epidemiology, pathophysiology, and essential primary skin lesions used to diagnose staphylococcal scalded skin syndrome are summarized for the pediatric emergency medicine physician.<\/jats:p>","DOI":"10.1097\/pec.0000000000002564","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T02:00:48Z","timestamp":1636336848000},"page":"133-135","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Recognizing and Managing Staphylococcal Scalded Skin Syndrome in the Emergency Department"],"prefix":"10.1097","volume":"38","author":[{"given":"Quoc-Bao D.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai-Anh N.","family":"Vu","sequence":"additional","affiliation":[{"name":"UTMB School of Medicine, Galveston, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaide A.","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"bib1-20250504","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2174\/1874285801610010150","article-title":"A systemic review on staphylococcal scalded skin syndrome (SSSS): a rare and critical disease of neonates","volume":"10","year":"2016","journal-title":"Open Microbiol J"},{"key":"bib2-20250504","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2165\/00128071-200304030-00003","article-title":"Staphylococcal scalded skin syndrome: diagnosis and management","volume":"4","year":"2003","journal-title":"Am J Clin Dermatol"},{"key":"bib3-20250504","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/bjd.16097","article-title":"Epidemiology of staphylococcal scalded skin syndrome in U.S. children","volume":"178","year":"2018","journal-title":"Br J Dermatol"},{"key":"bib4-20250504","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/pde.12114","article-title":"Staphylococcal scalded skin syndrome in neonates: an 8-year retrospective study in a single institution","volume":"31","year":"2014","journal-title":"Pediatr Dermatol"},{"key":"bib5-20250504","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/jdv.12541","article-title":"Staphylococcal scalded skin syndrome: diagnosis and management in children and adults","volume":"28","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"bib6-20250504","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/archderm.1975.01630210051002","article-title":"Toxic epidermal necrolysis","volume":"111","year":"1975","journal-title":"Arch Dermatol"},{"key":"bib7-20250504","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.burns.2011.08.005","article-title":"Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study","volume":"38","year":"2012","journal-title":"Burns"},{"key":"bib8-20250504","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.12.2.224","article-title":"Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome","volume":"12","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"bib9-20250504","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s15010-017-1084-2","article-title":"An outbreak of skin infections in neonates due to a Staphylococcus aureus strain producing the exfoliative toxin A","volume":"46","year":"2018","journal-title":"Infection"},{"key":"bib12-20250504","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/archderm.1977.01640020079014","article-title":"Staphylococcal scalded skin syndrome. 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