{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:24:03Z","timestamp":1794313443282,"version":"4.9.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>This study aimed to analyze the prevalence of invasive bacterial infection (IBI) among infants younger than 90 days with fever without source according to the degree of fever.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We performed a secondary analysis of a multicenter study with 19 participating Spanish pediatric emergency departments that included 3401 febrile infants 90 days or younger.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Prevalence of IBI was 3.2% (5.3% among infants &lt;29 days old, 2.5% among those 29\u201360 days old, and 2.2% among those 61\u201390 days old). Prevalence of bacteremia increased with the degree of fever, meanwhile the prevalence of bacterial meningitis did not. No cutoff point was useful for ruling out an IBI safely. Overall, 46.7% of the IBIs were diagnosed in patients with temperature &lt;38.6\u00b0 (sensitivity, 53.3%; negative likelihood ratio, 0.81).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Performing blood tests should be recommended in infants 90 days or younger with temperature \u226538\u00b0C without source regardless of the degree of fever.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000002729","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T23:00:07Z","timestamp":1650322807000},"page":"e1294-e1297","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Value of Temperature for Predicting Invasive Bacterial Infection in Febrile Infants"],"prefix":"10.1097","volume":"38","author":[{"given":"Mercedes","family":"de la Torre","sequence":"first","affiliation":[{"name":"Pediatric Emergency Department, Ni\u00f1o Jes\u00fas University Hospital, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Cruces University Hospital, Barakaldo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Velasco","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Rio Hortega Universitary Hospital, Valladolid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Group for Study of Febrile Infant of Spanish Pediatric Emergency Research Group (RISeuP-SPERG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"bib1-20250504","doi-asserted-by":"crossref","first-page":"e20154381","DOI":"10.1542\/peds.2015-4381","article-title":"Validation of the \u201cstep-by-step\u201d approach in the management of young febrile infants","volume":"138","year":"2016","journal-title":"Pediatrics"},{"key":"bib2-20250504","article-title":"Fever in under 5\u2019s: assesment and initial management","year":"2017","journal-title":"Clin Guidel [Internet]"},{"key":"bib4-20250504","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1001\/jama.291.10.1203","article-title":"Management and outcomes of care of fever in early infancy","volume":"291","year":"2004","journal-title":"JAMA"},{"key":"bib5-20250504","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1542\/peds.108.2.311","article-title":"Predictive model for serious bacterial infections among infants younger than 3 months of age","volume":"108","year":"2001","journal-title":"Pediatrics"},{"key":"bib6-20250504","doi-asserted-by":"crossref","first-page":"e20183604","DOI":"10.1542\/peds.2018-3604","article-title":"A prediction model to identify febrile infants \u226460 days at low risk of invasive bacterial infection","volume":"144","year":"2019","journal-title":"Pediatrics"},{"key":"bib7-20250504","first-page":"42","article-title":"Aetiology and outcomes of potentially serious infections in febrile infants less than 3 months old","volume":"87","year":"2017","journal-title":"An Pediatr (Barc)"},{"key":"bib8-20250504","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1097\/INF.0000000000002461","article-title":"Prevalence of bacterial infection in febrile infant 61\u201390 days old compared with younger infants","volume":"38","year":"2019","journal-title":"Pediatr Infect Dis J"},{"key":"bib9-20250504","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1136\/emermed-2013-202449","article-title":"Accuracy of a sequential approach to identify young febrile infants at low risk for invasive bacterial infection","volume":"31","year":"2014","journal-title":"Emerg Med J"},{"key":"bib10-20250504","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/000992289303200303","article-title":"What is fever? Normal temperature in infants less than 3 months old","volume":"32","year":"1993","journal-title":"Clin Pediatr (Phila)"},{"key":"bib11-20250504","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1542\/peds.113.6.1662","article-title":"Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections","volume":"113","year":"2004","journal-title":"Pediatrics"},{"key":"bib12-20250504","first-page":"665","article-title":"Invasive bacterial infections in young afebrile infants with a history of fever","volume":"103","year":"2018","journal-title":"Arch Dis Child"},{"key":"bib13-20250504","doi-asserted-by":"crossref","first-page":"e20183964","DOI":"10.1542\/peds.2018-3964","article-title":"Serious bacterial infections in neonates presenting afebrile with history of fever","volume":"144","year":"2019","journal-title":"Pediatrics"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T18:11:02Z","timestamp":1746382262000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002729"}},"subtitle":["A Spanish Pediatric Emergency Research Group (RISeuP-SPERG) Study"],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000002729","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"value":"1535-1815","type":"electronic"},{"value":"0749-5161","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,18]]}}}