{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:14:31Z","timestamp":1781133271207,"version":"3.54.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>Sepsis and meningitis in children may present with different clinical features and a wide range of values of inflammatory markers. The aim of this study was to identify the prognostic value of clinical features and biomarkers in children with sepsis and bacterial meningitis in the emergency department (ED).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We carried out a single-center, retrospective, observational study on 194 children aged 0 to 14 years with sepsis and bacterial meningitis admitted to the pediatric ED of a tertiary children's hospital through 12 years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Among epidemiological and early clinical features, age older than 12 months, capillary refill time greater than 3 seconds, and oxygen blood saturation lower than 90% were significantly associated with unfavorable outcomes, along with neurological signs (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.05). Among laboratory tests, only procalcitonin was an accurate and early prognostic biomarker for sepsis and bacterial meningitis in the ED, both on admission and after 24 hours. Procalcitonin cut-off value on admission for short-term complications was 19.6 ng\/mL, whereas the cut-off values for long-term sequelae were 19.6 ng\/mL on admission and 41.9 ng\/mL after 24 hours, respectively. The cut-off values for mortality were 18.9 ng\/mL on admission and 62.4 ng\/mL at 24 hours.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Procalcitonin, along with clinical evaluation, can guide the identification of children at higher risk of morbidity and mortality, allowing the most appropriate monitoring and treatment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000002865","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T13:00:14Z","timestamp":1675083614000},"page":"311-317","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Clinical Predictors and Biomarkers in Children With Sepsis and Bacterial Meningitis"],"prefix":"10.1097","volume":"39","author":[{"given":"Emanuele","family":"Castagno","sequence":"first","affiliation":[{"name":"Department of Pediatric Emergency, Regina Margherita Children's Hospital - A.O.U. Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Aguzzi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency, Regina Margherita Children's Hospital - A.O.U. Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Pediatrics and Neonatology, P.O. Ciri\u00e8, ASL-TO4, Ciri\u00e8 (TO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachele","family":"Gallo","sequence":"additional","affiliation":[{"name":"Pediatric Department, E. Agnelli Hospital, Pinerolo (TO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Carpino","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatrics, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Ricceri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, Orbassano (TO), Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio F.","family":"Urbino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency, Regina Margherita Children's Hospital - A.O.U. Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bondone","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency, Regina Margherita Children's Hospital - A.O.U. Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"bib1-20250504","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"bib2-20250504","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.pcl.2018.07.012","article-title":"Recognition, diagnostics, and management of pediatric severe sepsis and septic shock in the emergency department","volume":"65","year":"2018","journal-title":"Pediatr Clin North Am"},{"key":"bib3-20250504","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1089\/sur.2017.316","article-title":"Pediatric sepsis update: how are children different?","volume":"19","year":"2018","journal-title":"Surg Infect (Larchmt)"},{"key":"bib4-20250504","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1542\/peds.2010-0277","article-title":"Clinical features suggestive of meningitis in children: a systematic review of prospective data","volume":"126","year":"2010","journal-title":"Pediatrics"},{"key":"bib5-20250504","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","year":"2018","journal-title":"Lancet Respir Med"},{"key":"bib6-20250504","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","article-title":"Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012","volume":"41","year":"2013","journal-title":"Crit Care Med"},{"key":"bib7-20250504","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1056\/NEJMoa1005384","article-title":"Emerging Infections Programs network. 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