{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:18:13Z","timestamp":1774048693902,"version":"3.50.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To define the presentation, spectrum of illness, and outcomes in infants with parechovirus (PeV) meningitis admitted to our inpatient general pediatrics service during a spike in incidence of admissions in summer 2022.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patients and Methods<\/jats:title>\n            <jats:p>This study is a retrospective case series of all patients aged 3 months and younger discharged from our institution with a CSF BioFire (BioFire Diagnostics, Salt Lake City, UT) FilmArray Polymerase Chain Reaction Meningitis\/Encephalitis Panel result positive for PeV between January 1 and September 19, 2022. We collected and analyzed clinical and demographic data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Eighteen infants with PeV meningitis were admitted within our time frame, with 8 (44%) of the admissions occurring in July. Patients' mean age was 28.7 days and mean length of stay was 50.5 hours. Although all had a history of fever, only 72% were febrile on presentation. Laboratory findings showed a procalcitonin of less than 0.5 ng\/mL in 86% of the 14 patients who had it drawn and no cerebrospinal fluid (CSF) pleocytosis in 83% of the patients who had CSF cell counts sent. Neutropenia was present in 17%. Although 89% of infants were given initial antibiotics, antibiotics were discontinued in 63% once their CSF panel returned positive for PeV, and in all by 48 hours.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Infants hospitalized with PeV meningitis were febrile and fussy, but experienced uncomplicated hospital stays without neurological deficits. Parechovirus meningitis must be considered as a common cause of acute viral meningitis in young infants even without CSF pleocytosis. This study, although limited in scope and follow-up, can potentially assist in the diagnosis and treatment of PeV meningitis at other institutions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000002973","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T19:06:15Z","timestamp":1684523175000},"page":"22-26","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A Summer of Fevers and Fussiness"],"prefix":"10.1097","volume":"40","author":[{"given":"Sarah J.","family":"Calardo","sequence":"first","affiliation":[{"name":"Nemours Children's Hospital, Delaware, Wilmington, DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niketa","family":"Raj","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Loiselle","sequence":"additional","affiliation":[{"name":"Nemours Children's Hospital, Delaware, Wilmington, DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holli","family":"Zerhusen","sequence":"additional","affiliation":[{"name":"Nemours Children's Hospital, Delaware, Wilmington, DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Solaiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"bib2-20250504","first-page":"e00047","article-title":"Human parechovirus: an increasingly recognized cause of sepsis-like illness in young infants","volume":"31","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"bib3-20250504","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00431-014-2483-3","article-title":"Characteristics and outcomes of human parechovirus infection in infants (2008\u20132012)","volume":"174","year":"2015","journal-title":"Eur J Pediatr"},{"key":"bib4-20250504","doi-asserted-by":"crossref","first-page":"e20152848","DOI":"10.1542\/peds.2015-2848","article-title":"Parechovirus encephalitis and neurodevelopmental outcomes","volume":"137","year":"2016","journal-title":"Pediatrics"},{"key":"bib5-20250504","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1128\/JCM.01680-12","article-title":"Human parechovirus in respiratory specimens from children in Kansas City, Missouri","volume":"50","year":"2012","journal-title":"J Clin Microbiol"},{"key":"bib6-20250504","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/INF.0000000000001082","article-title":"Prolonged shedding of human parechovirus in feces of young children after symptomatic infection","volume":"35","year":"2016","journal-title":"Pediatr Infect Dis J"},{"key":"bib7-20250504","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3345\/kjp.2015.58.3.102","article-title":"Prevalence of human parechovirus and enterovirus in cerebrospinal fluid samples in children in Jinju, Korea","volume":"58","year":"2015","journal-title":"Korean J Pediatr"},{"key":"bib9-20250504","doi-asserted-by":"crossref","first-page":"e2021052228","DOI":"10.1542\/peds.2021-052228","article-title":"Evaluation and management of well-appearing febrile infants 8 to 60 days old","volume":"148","year":"2021","journal-title":"Pediatrics"},{"key":"bib10-20250504","article-title":"CDC issues parechovirus alert","year":"2022","journal-title":"EverydayHealthcom"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T18:10:10Z","timestamp":1746382210000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000002973"}},"subtitle":["Eighteen Infants Admitted With Parechovirus Meningitis"],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000002973","relation":{},"ISSN":["1535-1815","0749-5161"],"issn-type":[{"value":"1535-1815","type":"electronic"},{"value":"0749-5161","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,22]]}}}