{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:11:21Z","timestamp":1773972681050,"version":"3.50.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>There is lack of evidence-based information on the use and timing of endotracheal intubation (ETI) in children with prehospital status epilepticus (SE).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The aim of this study was to investigate ETI use, timing, risk factors, and outcomes in children presenting to a single-center children's emergency (CE) with prehospital SE, over a 5-year period.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 118 events involving children presenting to CE with ongoing prehospital SE were included, and 39% (46\/118) of the events required ETI. The most common indication for ETI was respiratory depression. The median time to intubation after arrival at CE was 20.0 minutes (1\u2013155 minutes). Risk factors associated with ETI use include the administration of more than 2 benzodiazepines (26.1% vs 4.2%, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) and the use of second- or third-line antiepileptic therapy (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). The use of more than 2 doses of benzodiazepines was found in 12.7% (15\/118) of the patients. In patients who received excessive benzodiazepines, 87% (13\/15) of them required intubation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Excessive use of benzodiazepine was found to be a main risk factor for ETI in patients with prehospital SE. Avoidance of the excessive use of benzodiazepines and adhering to clinical management guidelines may reduce the risk for ETI in the CE. The best approach to airway management in children with prehospital SE is lacking and urgently needed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000003137","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T08:00:05Z","timestamp":1708156805000},"page":"e40-e45","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Excessive Use of Benzodiazepines Is a Risk Factor for Endotracheal Intubation in Children Who Present to Emergency With Prehospital Status Epilepticus"],"prefix":"10.1097","volume":"40","author":[{"given":"Velda X.","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Hang","family":"Goh","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Shan","family":"Boi","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University Singapore, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy B.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furene S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Y.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pao Tang","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"bib1-20250504","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus\u2014report of the ILAE task force on 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