{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:30:38Z","timestamp":1787311838680,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sickle cell disease (SCD) is an important topic for emergency medicine audiences because complications of the disease account for a large proportion of hematologic emergencies that are seen in the emergency department each year. Early recognition and aggressive management of emergency complications of SCD can help to reduce the morbidity and mortality associated with this disease. Although the treatment recommendations for some complications of SCD are based on expert opinion, there has been advancement in the understanding of the pathogenesis of the disease and evidence regarding the treatment options available for managing acute complications. This continuing medical education article will provide a summary of the clinical manifestation and management of the most common acute complications of SCD: infection, vaso-occlusive episode, acute chest syndrome, splenic sequestration, stroke, and priapism.<\/jats:p>","DOI":"10.1097\/pec.0000000000003159","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T12:01:52Z","timestamp":1715688112000},"page":"406-411","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["New Horizons in Emergency Department Management of Pediatric Sickle Cell Disease"],"prefix":"10.1097","volume":"40","author":[{"given":"Jasmine","family":"Umana","sequence":"first","affiliation":[{"name":"Postdoctoral Research Fellow, Pediatric Emergency Medicine Attending, Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, 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