{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:19:32Z","timestamp":1779373172373,"version":"3.53.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>Central venous saturation (ScvO<jats:sub>2<\/jats:sub>) can guide resuscitation of children with septic shock. The normal range of ScvO<jats:sub>2<\/jats:sub> is typically considered as 0.70\u20130.80, but has not been established in children with cancer. Children with cancer are particularly prone to develop sepsis due to their immunosuppressive therapy, and usually have a permanent central venous catheter, making ScvO<jats:sub>2<\/jats:sub> readily available. We aimed to investigate normal values of ScvO<jats:sub>2<\/jats:sub> in clinically stable children with cancer, and the association between ScvO<jats:sub>2<\/jats:sub>, hemoglobin, and lactate.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted a prospective clinical study at the outpatient clinic of a tertiary pediatric hematology\/oncology unit. Blood samples were collected from stable children aged 0\u201317.9 years who were treated for cancer between January 1 and November 30, 2019, during their routine outpatient clinic visits.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 183 blood samples were collected from 68 patients (24 girls and 44 boys). The predicted mean level of ScvO2 with a 95% confidence interval was 0.67 (0.56\u20130.78). The ScvO<jats:sub>2<\/jats:sub> value was below the expected lower normal limit of 0.70 in 126 (69%) of the samples and in 48 patients (71%) at least once. ScvO<jats:sub>2<\/jats:sub> was significantly associated with hemoglobin (<jats:italic toggle=\"yes\">\u03b2<\/jats:italic>1 = 0.012 per g\/L hemoglobin, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), but not with age, sex, underlying diagnosis, or lactate.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The study revealed that a substantial portion of clinically stable childhood cancer patients exhibited ScvO<jats:sub>2<\/jats:sub> levels below the typical reference value of 0.70, suggesting that these children may have inherently lower baseline ScvO<jats:sub>2<\/jats:sub> levels. This should be kept in mind when evaluating children with cancer for septic shock, emphasizing the importance of tailored assessments in this population. Further understanding of baseline ScvO<jats:sub>2<\/jats:sub> abnormalities may be helpful if ScvO<jats:sub>2<\/jats:sub> is used to guide resuscitation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000003254","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T20:12:37Z","timestamp":1723666357000},"page":"901-903","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Central Venous Oxygen Saturation in Children With Cancer"],"prefix":"10.1097","volume":"40","author":[{"given":"Nadja Hawwa","family":"Vissing","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kia Hee Schultz","family":"Dungu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik M\u00f8lkj\u00e6r","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Biostatistics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Bondo","family":"M\u00f8nster","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Lyngsie","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrikka","family":"Nygaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"bib1-20250504","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","year":"2001","journal-title":"N Engl J Med"},{"key":"bib2-20250504","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/MCC.0000000000000336","article-title":"Assessment of the adequacy of oxygen delivery","volume":"22","year":"2016","journal-title":"Curr Opin Crit Care"},{"key":"bib3-20250504","first-page":"1572","article-title":"Continuous central venous and 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