{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:33:21Z","timestamp":1771886001589,"version":"3.50.1"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Pediatr Emer Care"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>The presence of hypothermia among young infants in the emergency department may be a sign of serious or invasive bacterial infections, or invasive herpes simplex viral infection. However, hypothermia may also occur due to a variety of other infectious and noninfectious conditions or environmental exposure. In some settings, hypothermia may represent a protective, energy-conserving response to illness. Recent efforts have enhanced our understanding of the prevalence of serious infections among infants with hypothermia, although challenges remain due to lack of standardized definitions and comprehensive guidelines. There exists extensive variation in the care of young infants with hypothermia. Risk factors for serious bacterial infections in infants with hypothermia, as identified in single-center and multicenter retrospective studies, include lower temperatures, older age, and abnormalities in blood and urine testing. Given the absence of clear guidelines, management of infants with hypothermia relies heavily on clinician judgment and shared decision making, guided by individual patient assessments and risk factors. This review article summarizes existing evidence and identifies gaps in the management of infants (&lt;90 days) with hypothermia in the emergency department.<\/jats:p>","DOI":"10.1097\/pec.0000000000003259","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T19:00:10Z","timestamp":1738263610000},"page":"146-151","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Current Evidence on the Care of Young Infants With Hypothermia in the Emergency Department"],"prefix":"10.1097","volume":"41","author":[{"given":"Sriram","family":"Ramgopal","sequence":"first","affiliation":[{"name":"Assistant Professor, Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Hsiang J.","family":"Lo","sequence":"additional","affiliation":[{"name":"Instructor, Division of Pediatric Emergency Medicine, Department of Emergency Medicine, Weill Cornell Medicine, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M.","family":"Potisek","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Pediatrics, University of South Carolina School of Medicine Greenville, Prisma Health Children's Hospital-Upstate, Greenville, SC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan M.","family":"Money","sequence":"additional","affiliation":[{"name":"Assistant Professor, Division of Pediatric Hospital Medicine, University of Utah School of Medicine, Salt Lake City, UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth E.","family":"Halvorson","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea T.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Professor, Divisions of Emergency Medicine and Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Professor, Departments of Emergency Medicine and Pediatrics, University of Michigan, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20250130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1542\/hpeds.2023-007356","article-title":"Predicting serious bacterial infections among hypothermic infants in the emergency department","volume":"14","year":"2024","journal-title":"Hosp Pediatr"},{"key":"bib2-20250130","doi-asserted-by":"crossref","first-page":"113407","DOI":"10.1016\/j.jpeds.2023.113407","article-title":"Prevalence of invasive bacterial infection in hypothermic young infants: a multisite study","volume":"258","year":"2023","journal-title":"J Pediatr"},{"key":"bib3-20250130","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.ajem.2019.04.015","article-title":"Factors associated with serious bacterial infections in infants \u226460 days with hypothermia in the emergency department","volume":"37","year":"2019","journal-title":"Am J Emerg Med"},{"key":"bib4-20250130","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/INF.0b013e3181646d95","article-title":"Clinical and laboratory features of neonatal herpes simplex virus infection: a case-control study","volume":"27","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"bib5-20250130","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jpeds.2008.02.031","article-title":"The prevalence of neonatal herpes simplex virus infection compared with serious bacterial illness in hospitalized neonates","volume":"153","year":"2008","journal-title":"J Pediatr"},{"key":"bib6-20250130","first-page":"e124","article-title":"Hypothermia: a sign of sepsis in young infants in the emergency department?","volume":"37","year":"2018","journal-title":"Pediatr Emerg Care"},{"key":"bib7-20250130","doi-asserted-by":"crossref","first-page":"e2022058213","DOI":"10.1542\/peds.2022-058213","article-title":"Hypothermia in young infants","volume":"150","year":"2022","journal-title":"Pediatrics"},{"key":"bib8-20250130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-2004-837265","article-title":"Premature infants are less capable of maintaining thermal balance of head and body with increases of thermal environment than with decreases","volume":"22","year":"2005","journal-title":"Am J Perinatol"},{"key":"bib9-20250130","doi-asserted-by":"crossref","first-page":"e643","DOI":"10.1542\/peds.2006-0943","article-title":"Admission temperature of low birth weight infants: predictors and associated morbidities","volume":"119","year":"2007","journal-title":"Pediatrics"},{"key":"bib10-20250130","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1542\/peds.22.5.876","article-title":"The influence of the thermal environment upon the survival of newly born premature infants","volume":"22","year":"1958","journal-title":"Pediatrics"},{"key":"bib11-20250130","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/bmj.1.5169.303","article-title":"Cold injury in the newborn. 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