{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:18:23Z","timestamp":1788509903230,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of the study is to assess the changes in the pediatric care of patients seen in the Pediatric Emergency Departments (PED) during the bronchiolitis season following the introduction of immunization with a monoclonal antibody against RSV (nirsevimab).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      An observational, retrospective, multicenter study was conducted, analyzing the Bronchiolitis Registry of the Spanish Society of Pediatric Emergency Medicine. This registry, containing data on bronchiolitis cases, was initiated in December 2022. A total of 30 hospitals participated, all of which are members of the Spanish Society of Pediatric Emergency Medicine. Data from a 26-day period in 2 bronchiolitis seasons (2022: preimmunization and 2023: postimmunization) were included. Variables regarding health care burden were recorded for both periods. Quantitative variables were described using mean and SD, and the Student\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test was used for comparisons between the 2 periods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-five hospitals from 11 autonomous communities were included with a mean of 47,811 PED visits\/year (SD: 26,675). The number of bronchiolitis cases presenting to the PED and bronchiolitis-related admissions decreased by 41.6%(95% CI: 34.9%-48.2%) and 55.4% (95% CI: 46.6%-64.2%), respectively, while admissions for RSV bronchiolitis decreased by 60.3% (95% CI: 51.9%-68.7%). Admissions to pediatric intensive care units decreased by 81.3% (95% CI: 57.9%-100%). Furthermore, the occupancy rate in the pediatric intensive care units decreased by 30% (95% CI: 22.8%-37.3%), while a reduction of 22.4% (95% CI: 13.2%-31.5%) was observed in the occupancy rate of observation units. The number of bronchiolitis cases transferred to other hospitals decreased by 73.4% (95% CI: 29.0%-100%). Finally, there was a 60.9% (95% CI: 26.5%-95.3%) reduction in the need for high-flow oxygen therapy among bronchiolitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>After the introduction of nirsevimab, a large portion of indicators related to the burden of care associated with bronchiolitis during its epidemic season decreased significantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/pec.0000000000003339","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T01:00:06Z","timestamp":1738890006000},"page":"365-371","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Changes in Care in Spanish Pediatric Emergency Departments After the First Immunization With Nirsevimab"],"prefix":"10.1097","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9210-0508","authenticated-orcid":false,"given":"Paula","family":"Vazquez-Lopez","sequence":"first","affiliation":[{"name":"Pediatric Emergency Department, Gregorio Mara\u00f1on University Hospital, Gregorio Mara\u00f1on Health Research Institute, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristides","family":"Rivas-Garcia","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Gregorio Mara\u00f1on University Hospital, Gregorio Mara\u00f1on Health Research Institute, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Luaces-Cubells","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Sant Joan de D\u00e9u University Hospital, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Perez-Gonzalez","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Virgen Macarena University Hospital, Sevilla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Ales-Palmer","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Virgen de las Nieves University Hospital, Granada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Cahis-Vela","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Consorci Corporaci\u00f3 Sanitaria Parc Tauli, Sabadell"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Lera-Carballo","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Vall d'Hebron University Hospital, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Solano-Navarro","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Virgen de la Arrixaca Clinic University Hospital, Murcia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Romero-Castillo","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Puerta del Mar University Hospital, C\u00e1diz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Patricia","family":"Torres-Begara","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Virgen de Valme University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jesus","family":"Sanchez-Alvarez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Virgen del Roc\u00edo University Hospital, Sevilla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Benito-Fernandez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Cruces University Hospital, Biocruces Health Research Institute, Barakaldo, Bizkaia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sanz-Rueda","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, R\u00edo Hortega University Hospital, Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Angeles","family":"Garcia-Herrero","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Pr\u00edncipe de Asturias University Hospital, Alcal\u00e1 de Henares"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Henares-Rodriguez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, San Cecilio University Hospital, Granada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ya\u00f1ez-Mesia","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, A Coru\u00f1a University Hospital Complex, A Coru\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"de Francisco-Profumo","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Germans Trias i Pujol University Hospital, Badalona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Martinez-Mejias","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Consorci Sanitari de Terrassa University Hospital, Terrassa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"May-Llanas","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Mutua Terrassa University Hospital, Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Mesa-Garcia","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, 12 de Octubre University Hospital, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Aranda-Mora","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Reina Sof\u00eda University Hospital, Cordoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepcion","family":"Baquero-Gomez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Juan Ramon Jimenez University Hospital, Huelva"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"de la Rosa-Sanchez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Insular Materno Infantil University Hospital Complex, Las Palmas de Gran Canaria, Gran Canaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de Ceano\u2013Vivas","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, La Paz University Hospital, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"de la Torre Esp\u00ed","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Ni\u00f1o Jesus University Hospital, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Oliva-Rodriguez-Pastor","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Regional University Hospital, Malaga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\ufeffse Lorenzo","family":"Guerra-Diez","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Marques de Valdecilla University Hospital, Santander"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pons-Morales","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Doctor Peset Hospital, Valencia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Gomez-Carabaza","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Joan XXIII University Hospital, Tarragona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Campos-Calleja","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Miguel Servet University Children\u2019s Hospital, Zaragoza"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Ramon","family":"Torres-Torres","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Miguel Servet University Children\u2019s Hospital, Zaragoza"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"R1-20250430","doi-asserted-by":"crossref","first-page":"134","DOI":"10.37201\/req\/147.2023","article-title":"Respiratory syncytial virus: a new era","volume":"37","author":"Ruiz-Galiana","year":"2024","journal-title":"Rev Esp Quimioter"},{"key":"R2-20250430","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/infdis\/jiz409","article-title":"Advanced live attenuated vaccines for the prevention of respiratory syncytial virus infections in young children","volume":"222","author":"Ramilo","year":"2020","journal-title":"J Infect Dis"},{"key":"R3-20250430","doi-asserted-by":"crossref","first-page":"e13100","DOI":"10.1111\/irv.13100","article-title":"Systematic literature review of the signs and symptoms of respiratory syncytial virus","volume":"17","author":"Colosia","year":"2023","journal-title":"Influenza Other Respir 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Nirsevimab: a new perspective on respiratory syncytial virus (RSV)","volume":"2","author":"Paniagua","year":"2023","journal-title":"Emerg Pediatr"},{"key":"R11-20250430","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.anpedi.2023.09.006","article-title":"Nirsevimab for the prevention of respiratory syncytial virus disease in children. 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Impact of nirsevimab prophylaxis on paediatric respiratory syncytial virus (RSV)-related hospitalisations during the initial 2023\/24 season in Luxembourg","volume":"29","author":"Ernst","year":"2024","journal-title":"Euro Surveill"},{"key":"R21-20250430","doi-asserted-by":"crossref","first-page":"1441786","DOI":"10.3389\/fpubh.2024.1441786","article-title":"The effectiveness of nirsevimab in reducing the burden of disease due to respiratory syncytial virus (RSV) infection over time in the Madrid region (Spain): a prospective population-based cohort study","volume":"12","author":"Barbas Del Buey","year":"2024","journal-title":"Front Public Health"},{"key":"R22-20250430","doi-asserted-by":"crossref","first-page":"2400046","DOI":"10.2807\/1560-7917.ES.2024.29.6.2400046","article-title":"Early estimates of nirsevimab immunoprophylaxis effectiveness against hospital admission for respiratory syncytial virus lower respiratory tract infections in infants, Spain, October 2023 to January 2024","volume":"29","author":"L\u00f3pez-Lacort","year":"2024","journal-title":"Euro Surveill"},{"key":"R23-20250430","doi-asserted-by":"crossref","first-page":"2300606","DOI":"10.2807\/1560-7917.ES.2023.28.49.2300606","article-title":"Early lessons from the implementation of universal respiratory syncytial virus prophylaxis in infants with long-action monoclonal antibodies, Galicia, Spain, September and October 2023","volume":"28","author":"Martin\u00f3n -Torres","year":"2023","journal-title":"Euro Surveill"},{"key":"R24-20250430","doi-asserted-by":"crossref","first-page":"2348135","DOI":"10.1080\/21645515.2024.2348135","article-title":"Assessment of effectiveness and impact of universal prophylaxis with nirsevimab for prevention of hospitalizations due to respiratory syncytial virus in infants. The NIRSE-GAL study protocol","volume":"20","author":"Mallah","year":"2024","journal-title":"Hum Vaccin Immunother"},{"key":"R25-20250430","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12879-024-08988-9","article-title":"Evaluation of antibody-based preventive alternatives for respiratory syncytial virus: a novel multi-criteria decision analysis framework and assessment of nirsevimab in Spain","volume":"24","author":"Mestre Ferr\u00e1ndiz","year":"2024","journal-title":"BMC Infect Dis"},{"key":"R29-20250430","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijid.2023.10.023","article-title":"Epidemiology of respiratory viruses among children during the SARS-CoV-2 pandemic: a systematic review and meta-analysis","volume":"138","author":"Leonie","year":"2024","journal-title":"Int J Infect Dis"},{"key":"R30-20250430","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/jpids\/piad113","article-title":"Infants receiving a single dose of nirsevimab to prevent RSV do not have evidence of enhanced disease in their second RSV season","volume":"13","author":"Dagan","year":"2024","journal-title":"J Pediatric Infect Dis Soc"}],"container-title":["Pediatric Emergency Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000003339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:00:42Z","timestamp":1745989242000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PEC.0000000000003339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/pec.0000000000003339","relation":{},"ISSN":["0749-5161","1535-1815"],"issn-type":[{"value":"0749-5161","type":"print"},{"value":"1535-1815","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]}}}