{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:14:52Z","timestamp":1781792092302,"version":"3.54.5"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>During the coronavirus disease 2019 pandemic, there was a significant increase in pediatric emergency department visits and hospital admissions for suicidality and self-harm, including deliberate self-poisoning. This study compares demographics, clinical characteristics, management, and outcome data of pediatric patients with intentional self-poisonings before and during the pandemic. A secondary aim is to identify predictors of severe outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>De-identified data were retrieved from the Toxicology Investigators Consortium registry of patients ages 6 to 18 years presenting with intentional self-poisoning. \u03c7<jats:sup>2<\/jats:sup> analyses and Fisher exact test were performed to determine associations among variables between the \u201cpre-pandemic\u201d (April 2017 to February 2020) and \u201cpandemic\u201d (March 2020 to October 2022) periods, with <jats:italic toggle=\"yes\">P<\/jats:italic> value &lt;0.05 considered statistically significant. Multivariable logistic regression analysis was conducted to explore correlates of severe outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>There were 7034 cases identified, 3480 pre-pandemic and 3604 pandemic. The pandemic group was associated with a higher percentage of patients aged 7 to 12 years, patients identifying as transgender or gender non-conforming, and the use of non-opioid analgesics as a primary agent. The pre-pandemic group had more frequent polysubstance ingestions and severe outcomes. Subgroup analysis of severe outcomes showed few differences between pre-pandemic and pandemic groups. No demographic characteristics were strongly associated with severe outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The demographic differences between time periods suggest the pandemic may have had a disparate impact on these vulnerable populations. Identifying trends in pediatric self-poisonings may help guide public health strategies and resources for prevention and harm reduction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/pec.0000000000003376","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T07:04:20Z","timestamp":1742454260000},"page":"470-474","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Impact of the Coronavirus Disease 2019 Pandemic on Clinical Trends in Pediatric Intentional Self-Poisonings"],"prefix":"10.1097","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-403X","authenticated-orcid":false,"given":"Hannah","family":"Wilkins","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Arkansas for Medical 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