{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:56:07Z","timestamp":1787936167019,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The primary objective was to determine the area under the curve of optic nerve sheath diameter &gt;4.5\u00a0mm for detection of raised intracranial pressure in children aged 1 year to 12 years admitted to PICU with neurological signs and symptoms. Our secondary objectives were to compare optic nerve sheath values in study population with age and sex-matched controls and determine change after 30 minutes of osmotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred twenty-five children (40 with raised intracranial pressure, 45 without raised intracranial pressure, and 40 non-neurological controls) were enrolled. Optic nerve sheath diameter using point of care ultrasound was measured at admission and 30 minutes after initiation of osmotherapy in patients who received osmotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean optic nerve sheath diameter in children with raised intracranial pressure was 5.48 \u00b1 0.48 mm, while that without raised intracranial pressure was 5.14 \u00b1 0.57\u00a0mm and non-neurological controls was 4.54 \u00b1 0.24\u00a0mm. A diameter of &gt;4.5\u00a0mm was able to detect raised intracranial pressure with sensitivity of 100%, with area under the curve of 0.53. Best cutoff was determined to be 4.92\u00a0mm, with sensitivity of 90%, specificity of 46.67% and area under the curve of 0.68. Higher optic nerve sheath diameter was observed with increase in Friesen grading of papilledema. Also, a significant decrease in values was found after 30 minutes of osmotherapy, with no difference between 3% saline and 20% mannitol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Optic nerve sheath diameter using ultrasound was able to detect raised intracranial pressure with high sensitivity, but low specificity, with optimal cutoff observed as 4.92\u00a0mm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/pec.0000000000003447","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T06:00:13Z","timestamp":1753768813000},"page":"847-853","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Optic Nerve Sheath Diameter by Point of Care Ultrasound to Detect Raised Intracranial Pressure in 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