{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:09:29Z","timestamp":1793390969815,"version":"4.5.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Bacterial musculoskeletal infections (MSKIs) can be challenging to diagnose. We compared the accuracy of calcitonin gene\u2013related peptide (CGRP), a neuropeptide which is transcribed from the same gene as procalcitonin, to procalcitonin for the diagnosis of a MSKI in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a prospective cohort study of patients 21 years old or younger who underwent evaluation for MSKIs at one of 3 emergency departments. Our primary outcome was a MSKI, defined as septic arthritis, osteomyelitis, or pyomyositis. We used a Spearman correlation coefficient to measure the association between serum CGRP and procalcitonin and compared the diagnostic accuracy using area under the receiver operating characteristic curve (AUC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 200 enrolled patients, 33 (17%) had a MSKI. Overall, median serum CGRP level did not differ between patients with and without a MSKI (13.5 pg\/mL MSKI vs 10.9\u00a0pg\/mL no MSKI; difference: 2.6, 95% CI: \u22120.6, 5.8), while PCT was higher in patients with a MSKI (0.12\u00a0ng\/mL MSKIs vs 0.04\u00a0ng\/mL no MSKI; difference: 0.08, 95% CI: 0.03 to 0.13). CGRP and PCT levels were not correlated (Spearman rank coefficient: \u22120.01, 95% CI: \u22120.15 to 0.13). CGRP had a lower AUC than procalcitonin [0.57, 95% CI: 0.47 to 0.66 CGRP vs 0.78, 95% CI: 0.69 to 0.87 PCT,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although biochemically related, CGRP was not correlated with procalcitonin in children undergoing evaluation for a MSKI. Our exploratory pilot highlights the ongoing need for novel biomarkers for the accurate and timely identification of children with a MSKI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/pec.0000000000003520","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T04:00:08Z","timestamp":1764216008000},"page":"175-179","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Calcitonin Gene\u2013Related Peptide for Identifying Pediatric Bacterial Musculoskeletal Infections"],"prefix":"10.1097","volume":"42","author":[{"given":"Caroline G.","family":"Kahane","sequence":"first","affiliation":[{"name":"Division of Emergency Medicine, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise E.","family":"Nigrovic","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daping","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Majzoub","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Boston Children\u2019s Hospital and Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Kellogg","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Boston Children\u2019s Hospital and Department of Pathology, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seattle Children\u2019s Hospital and University of Washington School of Medicine, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea T.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac M.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd W.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"R1-20260227","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2023-061329","article-title":"Biomarkers for pediatric 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