{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:09:54Z","timestamp":1781629794960,"version":"3.54.5"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>We report the case of a girl with central precocious puberty (CPP) and nonalcoholic steatohepatitis (NASH) aggravated by gonadotropin\u2010releasing hormone analog (GnRHa). She was diagnosed with CCP and began treatment with GnRHa at the age of 8 years and 9 months. She already had mild liver dysfunction and was obese at that time; however, liver dysfunction was aggravated during GnRHa initiation. Her liver dysfunction improved after the discontinuation of GnRHa. Liver biopsy was performed twice during GnRHa initiation and findings suggested NASH. In this case, NASH may have been aggravated by the mechanism of estrogen suppression by GnRHa besides obesity. In conclusion, NASH should be ruled out in obese CPP patients with abnormal liver function before starting GnRHa therapy. CPP patients treated with GnRHa require close examination for the early diagnosis of NASH or its progression.<\/jats:p><\/jats:sec>","DOI":"10.1097\/pg9.0000000000000014","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T17:06:26Z","timestamp":1601399186000},"source":"Crossref","is-referenced-by-count":3,"title":["A Case of Nonalcoholic Steatohepatitis in Central Precocious Puberty Aggravated by Gonadotropin\u2010releasing Hormone Analog"],"prefix":"10.1002","volume":"1","author":[{"given":"Yoshiaki","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Abashiri\u2010Kosei General Hospital Abashiri City Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kajino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Abashiri\u2010Kosei General Hospital Abashiri City Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Gotoda","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo\u2010Kosei General Hospital Sapporo City Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2009.07.007"},{"key":"e_1_2_5_3_1","first-page":"374","article-title":"Steatohepatitis in obese children: a cause of chronic liver dysfunction","volume":"78","author":"Moran JR","year":"1983","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_4_1","first-page":"170","article-title":"Non\u2010alcoholic fatty liver disease in children","volume":"40","author":"Singer C","year":"2014","journal-title":"Curr Health Sci J"},{"key":"e_1_2_5_5_1","first-page":"7","article-title":"Influence of GnRH analog therapy on body mass in central precocious puberty","volume":"15","author":"G\u0142ab E","year":"2009","journal-title":"Pediatr Endocrinol Diabetes Metab"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00211.2011"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26761"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.37.931"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181a9387b"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/PG9.0000000000000014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T14:05:31Z","timestamp":1749737131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/PG9.0000000000000014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,28]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1097\/PG9.0000000000000014"],"URL":"https:\/\/doi.org\/10.1097\/pg9.0000000000000014","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,28]]},"article-number":"e014"}}