{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:06:24Z","timestamp":1793307984501,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p>Celiac disease (CD) is increasingly diagnosed without endoscopy. As such, the need for accurate serological markers to aid in the diagnosis and follow\u2010up of CD has increased. Intestinal fatty acid binding protein (I\u2010FABP) is a cytosolic protein present in enterocytes, whose blood levels reflect mucosal damage in a reliable and quantifiable way. The aim of this study was to compare I\u2010FABP levels in newly diagnosed patients with CD and to examine changes in levels following 6 months of gluten\u2010free diet (GFD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A prospective observational case control study of pediatric patients diagnosed with CD, with measurements of tissue transglutaminase IgA (TTG\u2010IgA) and I\u2010FABP levels at diagnosis and after 6 months of gluten free diet were compared to a control group of nonceliac patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>This study included 35 patients and 32 controls. The CD group had higher I\u2010FABP levels at diagnosis compared with the control group (median 641.7 pg\/mL versus 334 pg\/mL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). I\u2010FABP levels significantly differed between patients presenting with TTG\u2010IgA level 3\u201310 times the upper limit of normal (ULN) compared with those presenting with values &gt;10 times ULN (median 432.2 pg\/mL versus 796.2 pg\/mL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients with CD had a significant decrease in median I\u2010FABP levels after 6 months of GFD (median 268.2 pg\/mL), paralleling a decrease in TTG\u2010IgA and GFD adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>I\u2010FABP levels are increased in patients with CD at diagnosis compared with controls and decrease significantly while patients adhere to GFD.<\/jats:p><\/jats:sec>","DOI":"10.1097\/pg9.0000000000000070","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T20:00:25Z","timestamp":1617134425000},"source":"Crossref","is-referenced-by-count":9,"title":["Intestinal Fatty Acid Binding Protein Levels in Pediatric Celiac Patients in Transition From Active Disease to Clinical and Serological Remission"],"prefix":"10.1002","volume":"2","author":[{"given":"Assaf","family":"Hoofien","sequence":"first","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Guz\u2010Mark","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Zevit","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsachi","family":"Tsadok Perets","sequence":"additional","affiliation":[{"name":"Gastroenterology Laboratory Rabin Medical Center\u2014Beilinson Hospital Peath Tikva Israel"},{"name":"Adelson School of Medicine Ariel University Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Assa","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center Petach Tikva Israel"},{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheba Israel"},{"name":"6Pediatric Gastroenterology and Nutrition Unit Lady Davis Carmel Medical Center Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Layfer","sequence":"additional","affiliation":[{"name":"Gastroenterology Laboratory Rabin Medical Center\u2014Beilinson Hospital Peath Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"Matar","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered","family":"Nachmias\u2010Friedler","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Silbermintz","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Shamir","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_6_3_1","first-page":"473","article-title":"Serological tests for celiac disease as indicators of long\u2010term compliance with the gluten\u2010free diet","volume":"23","author":"Nachman F","year":"2011","journal-title":"Eur J Gastroenterol 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