{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:21:45Z","timestamp":1753878105554,"version":"3.41.2"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Epstein\u2010Barr virus (EBV) infections are prevalent in the pediatric population but are subclinical in the majority of cases. Elevated transaminases in the acute setting rarely increase beyond 5 times the normal upper limit. We present a girl aged 1 y with fever, vomiting, and diarrhea. Although initial physical examination was unremarkable, she developed jaundice, hepatomegaly, abdominal distension, and a maculopapular rash during admission. Laboratory investigations revealed marked increase in transaminases (alanine aminotransferase 7,664.5 IU\/L, aspartate aminotransferase 12,266 IU\/L), elevated \u03b3\u2010glutamyl transferase (224 IU\/L), and hyperbilirubinemia (total 130.7 \u00b5mol\/L, direct 104.9 \u00b5mol\/L). Abdominal ultrasound reported hepatomegaly with mild ascites. Serology revealed that both Monospot test and EBV immunoglobulin G were positive. With supportive therapy, improvement was noted within a week of symptom onset. We hereby elucidate the importance of considering EBV as a cause of acute cholestatic hepatitis in a very young pediatric patient who develops a rapid elevation of liver enzymes.<\/jats:p><\/jats:sec>","DOI":"10.1097\/pg9.0000000000000089","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T17:00:21Z","timestamp":1623776421000},"source":"Crossref","is-referenced-by-count":0,"title":["Unusual Presentation of Epstein\u2010Barr Virus\u2010Associated Cholestatic Hepatitis in an Infant"],"prefix":"10.1002","volume":"2","author":[{"given":"Raafat Hammad Seroor","family":"Jadah","sequence":"first","affiliation":[{"name":"Department of Paediatrics Bahrain Defence Force Royal Medical Services Riffa Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor Mohamed Ghassan","family":"Shaikho","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Bahrain Defence Force Royal Medical Services Riffa Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Abdulla","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Bahrain Defence Force Royal Medical Services Riffa Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5811\/cpcem.2019.10.45049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2015113"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-202213"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit321"},{"key":"e_1_2_8_6_1","first-page":"151","article-title":"The etiology of hypertransaminasemia in Turkish children","volume":"16","author":"Serdaro\u011flu F","year":"2016","journal-title":"Bosn J Basic Med Sci"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v1.i1.31"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21373"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.07.016"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/PG9.0000000000000089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T14:33:54Z","timestamp":1749738834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/PG9.0000000000000089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1097\/PG9.0000000000000089"],"URL":"https:\/\/doi.org\/10.1097\/pg9.0000000000000089","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"type":"print","value":"2691-171X"},{"type":"electronic","value":"2691-171X"}],"subject":[],"published":{"date-parts":[[2021,6,15]]},"article-number":"e089"}}