{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:40:02Z","timestamp":1754163602177,"version":"3.41.2"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>A small subset of endometrial endometrioid adenocarcinoma cases first reported in 2003, showed a distinct cervical component with a so-called \u201cburrowing\u201d invasion pattern. Initially, the cervical component was regarded as cervical involvement by the endometrial adenocarcinoma. However, a 2010 study argued that these cases actually might represent separate primary endometrial and cervical endometrioid adenocarcinomas. However, additional data on this topic are scarce. Here, we report a case of endometrioid adenocarcinoma with a \u201cburrowing\u201d cervical invasion that is morphologically distinct from the patient\u2019s endometrial endometrioid adenocarcinoma. By comparing the morphology, immunophenotype, and genetic profile obtained by next-generation sequencing, we demonstrated that the cervical and endometrial tumors were of 2 separate primaries. Our report adds additional data to this unique phenomenon, and will hopefully help to reignite interest in investigating this controversial topic.<\/jats:p>","DOI":"10.1097\/pgp.0000000000000990","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T18:00:27Z","timestamp":1699034427000},"page":"271-274","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Endometrioid Adenocarcinoma With \u201cBurrowing\u201d Invasion of the Cervix Represents a Separate Primary From the Concurrent Uterine Corpus Endometrial Endometrioid Adenocarcinoma: Histology, Immunohistochemistry, and Next-generation Sequencing Study of a Single Case"],"prefix":"10.1097","volume":"43","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, UT Southwestern Medical Center (Y.L., S.N.)"},{"name":"Department of Pathology, Parkland Hospital, (Y.L., S.N.), Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson","family":"Chen","sequence":"additional","affiliation":[{"name":"Coppell High School, Coppell, Texas (J.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Pathology, UT Southwestern Medical Center (Y.L., S.N.)"},{"name":"Department of Pathology, Parkland Hospital, (Y.L., S.N.), Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"issue":"2 pt 1","key":"R1-20250802","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/AOG.0b013e3182605bf1","article-title":"Endometrial cancer","volume":"120","author":"Sorosky","year":"2012","journal-title":"Obstet Gynecol"},{"key":"R3-20250802","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1097\/00000478-200308000-00005","article-title":"Endometrial endometrioid adenocarcinoma with a deceptive pattern of spread to the uterine cervix: a manifestation of stage IIb endometrial carcinoma liable to be misinterpreted as an independent carcinoma or a benign lesion","volume":"27","author":"Tambouret","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"R4-20250802","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/PGP.0b013e3181b8e951","article-title":"Endometrial endometrioid adenocarcinoma of the uterine corpus involving the cervix: some cases probably represent independent primaries","volume":"29","author":"Jiang","year":"2010","journal-title":"Int J Gynecol Pathol"},{"key":"R5-20250802","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1053\/j.semdp.2021.12.001","article-title":"Histopathologic diagnosis of endometrial precancers: updates and future directions","volume":"39","author":"Chen","year":"2022","journal-title":"Semin Diagn Pathol"},{"key":"R6-20250802","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/PAS.0000000000001810","article-title":"Reliable identification of endometrial precancers through combined Pax2, beta-catenin, and Pten immunohistochemistry","volume":"46","author":"Aguilar","year":"2022","journal-title":"Am J Surg Pathol"},{"key":"R7-20250802","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nature04225","article-title":"Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis","volume":"438","author":"Wu","year":"2005","journal-title":"Nature"},{"key":"R8-20250802","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-pathol-020117-043609","article-title":"Molecular genetics of endometrial carcinoma","volume":"14","author":"Bell","year":"2019","journal-title":"Annu Rev Pathol"}],"container-title":["International Journal of Gynecological Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PGP.0000000000000990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:01:05Z","timestamp":1754161265000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PGP.0000000000000990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/pgp.0000000000000990","relation":{},"ISSN":["0277-1691"],"issn-type":[{"type":"print","value":"0277-1691"}],"subject":[],"published":{"date-parts":[[2023,9,22]]}}}