{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:12:51Z","timestamp":1789153971948,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>Transient osteoporosis of the hip (TOH) is a rare, self-limiting bone marrow edema syndrome characterized by acute hip pain. Although metabolic, mechanical, and vascular factors have been proposed, the underlying cause remains unclear. We report a case of sequential unilateral TOH episodes, temporally related to semaglutide exposure and re-exposure, in a healthy middle-aged man with symptom resolution after drug discontinuation and conservative treatment. Semaglutide, a glucagon-like peptide-1 receptor agonist increasingly used off-label for weight loss, has not previously been linked to musculoskeletal complications. Although causality cannot be definitively established, the consistent temporal relationship between semaglutide exposure and symptom onset suggests a possible association. Given the growing use of semaglutide, clinicians should consider TOH in the differential diagnosis of acute atraumatic hip pain, and further studies are warranted to elucidate the underlying mechanisms of this association.<\/jats:p>","DOI":"10.1097\/phm.0000000000003003","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:00:53Z","timestamp":1775836853000},"page":"e147-e150","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Semaglutide-Associated Sequential Unilateral Transient Osteoporosis of the Hip"],"prefix":"10.1097","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0651-0557","authenticated-orcid":false,"given":"Aslinur","family":"Keles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-2089","authenticated-orcid":false,"given":"Kemal","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-4486","authenticated-orcid":false,"given":"Esra","family":"Giray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3824-4428","authenticated-orcid":false,"given":"Ozge Gulsum","family":"Illeez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"R1-20260911","doi-asserted-by":"crossref","first-page":"021","DOI":"10.26502\/fjr.2688007","article-title":"Transient osteoporosis of the hip: state of the art and review of literature","volume":"01","author":"Aprato","year":"2019","journal-title":"Fortune J Rheumatol"},{"key":"R2-20260911","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.CC.20.00722","article-title":"Similarity in sequential bilateral transient osteoporosis of the hip: a report of 3 cases","volume":"11","author":"Kuroda","year":"2021","journal-title":"JBJS Case Connect"},{"key":"R3-20260911","doi-asserted-by":"crossref","first-page":"7879","DOI":"10.3390\/jcm14217879","article-title":"Transient osteoporosis of the hip: clinical and radiological outcomes after combined pharmacologic and biophysical therapy","volume":"14","author":"Puma Pagliarello","year":"2025","journal-title":"J Clin Med"},{"key":"R4-20260911","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/medsci13040265","article-title":"Semaglutide from bench to bedside: the experimental journey towards a transformative therapy for diabetes, obesity and metabolic liver disorders","volume":"13","author":"Weiskirchen","year":"2025","journal-title":"Med Sci (Basel)"},{"key":"R5-20260911","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12178-025-09978-3","article-title":"The effects of GLP-1 agonists on musculoskeletal health and orthopedic care","volume":"18","author":"Gatto","year":"2025","journal-title":"Curr Rev Musculoskelet Med"},{"key":"R6-20260911","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1097\/PHM.0000000000001210","article-title":"Bone marrow edema: a case of regional migratory osteoporosis","volume":"99","author":"Pimenta","year":"2020","journal-title":"Am J Phys Med Rehabil"},{"key":"R7-20260911","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00592-025-02468-5","article-title":"Effect of GLP-1 receptor agonists on bone mineral density, bone metabolism markers, and fracture risk in type 2 diabetes: a systematic review and meta-analysis","volume":"62","author":"Tan","year":"2025","journal-title":"Acta Diabetol"},{"key":"R8-20260911","first-page":"dgag052","article-title":"Skeletal effect of semaglutide and tirzepatide in patients with increased risk of fractures","volume":"7","author":"Liu","year":"2026","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-20260911","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.3390\/jcm14196758","article-title":"GLP-1 agonists in cardiovascular diseases: mechanisms, clinical evidence, and emerging therapies","volume":"14","author":"Yang","year":"2025","journal-title":"J Clin Med"},{"key":"R10-20260911","doi-asserted-by":"crossref","first-page":"e039446","DOI":"10.1161\/JAHA.124.039446","article-title":"Glucagon-like peptide-1 receptor agonists and risk of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Liu","year":"2025","journal-title":"J Am Heart Assoc"}],"container-title":["American Journal of Physical Medicine &amp; 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