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In this review, we focus on 3 areas: (1) the natural history of CH; (2) the risks of progression of CH, including CH of indeterminate potential, clonal cytopenia of undetermined significance, and therapy-related CH, to myeloid malignancy; and (3) the challenges and unmet needs of CH management and research.<\/jats:p>","DOI":"10.1097\/ppo.0000000000000656","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T14:04:31Z","timestamp":1684332271000},"page":"130-137","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm\/Syndromes and Other Myeloid Neoplasms"],"prefix":"10.1097","volume":"29","author":[{"given":"Zhuoer","family":"Xie","sequence":"first","affiliation":[{"name":"Malignant Hematology Department, H. Lee Moffitt Cancer Center & Research Institute, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Adult Leukemia Program, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes M.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine, Yale Cancer Center and Smilow Cancer Hospital, Yale University School of Medicine, New Haven, CT."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Komrokji","sequence":"additional","affiliation":[{"name":"Malignant Hematology Department, H. 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