{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:02:15Z","timestamp":1791291735242,"version":"4.1.0"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Dupuytren\u2019s disease is a common complex disease caused by genetic and nongenetic factors. The role of many nongenetic risk factors is still unclear and debatable. This study aimed to systematically review the association between Dupuytren\u2019s disease and nongenetic risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A search strategy was developed based on the Population, Exposure, Comparison, Outcomes and Study framework. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses\u2013compliant literature search was conducted in MEDLINE, Embase, Scopus, Web of Science, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials from inception to November of 2018. Title and abstract and then full-text screening against eligibility criteria was performed independently by two reviewers, and consensus was achieved by a third reviewer. The Effective Public Health Practice Project and the Oxford Centre for Evidence Based Medicine tools were used to assess study quality and to evaluate the level of evidence of included studies, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Reviewers identified 4434 studies, of which 54 were included in the analysis. There was strong evidence for the association between Dupuytren\u2019s disease and advanced age, male sex, family history of Dupuytren\u2019s disease, and diabetes mellitus. Furthermore, heavy alcohol drinking, cigarette smoking, and manual work exposure showed a significant dose-response relationship. The quality of the included studies was mainly low or moderate, and most studies were level 3 or 4 on the Oxford Centre for Evidence Based Medicine scale.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The study results show a strong association between Dupuytren\u2019s disease and advanced age, male sex, family history of Dupuytren\u2019s disease, diabetes mellitus, heavy alcohol drinking, cigarette smoking, and manual work exposure. Further studies are required to explain the causal relationship of these associations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/prs.0000000000007146","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T01:00:57Z","timestamp":1600736457000},"page":"799-807","source":"Crossref","is-referenced-by-count":32,"title":["Nongenetic Factors Associated with Dupuytren\u2019s Disease: A Systematic Review"],"prefix":"10.1097","volume":"146","author":[{"given":"Osaid H.","family":"Alser","sequence":"first","affiliation":[{"name":"From the Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre; and the Salisbury District Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Y. L.","family":"Kuo","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre; and the Salisbury District Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Furniss","sequence":"additional","affiliation":[{"name":"From the Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre; and the Salisbury District Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"R2-20231109","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1753193414548965","article-title":"Commentary on Larson et al. 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