{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T19:14:30Z","timestamp":1794597270289,"version":"4.9.1"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n            <jats:title>Summary:<\/jats:title>\n            <jats:p>The purpose of this study was to delineate optimal age to perform unilateral or bilateral cleft lip repair in premature patients. The American College of Surgeons National Surgical Quality Improvement Program Pediatric data set was queried for unilateral and bilateral cleft lip repairs performed between 2012 and 2017. Complications, readmissions, and reoperations were analyzed in the context of prematurity with appropriate statistics. Degree of prematurity was significantly associated with adverse events (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.001, <jats:italic toggle=\"yes\">r<\/jats:italic>\n                                 <jats:sub>s<\/jats:sub> = 0.44). Premature patients with unilateral cleft lip had a significantly decreased risk of adverse events when performing cleft lip repair after 150 days of age [OR, 18.1; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.004; before cutoff, <jats:italic toggle=\"yes\">n<\/jats:italic> = 10 of 140 (7.1 percent); after cutoff, <jats:italic toggle=\"yes\">n<\/jats:italic> = 0 of 112 (0.0 percent)] in the absence of other risk factors. Premature patients with bilateral cleft lip had a significantly decreased risk of adverse events when performing cleft lip repair after 175 days of age (OR, 16.1; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.010; before cutoff, <jats:italic toggle=\"yes\">n<\/jats:italic> = 7 of 33 (21.2 percent); after cutoff, <jats:italic toggle=\"yes\">n<\/jats:italic> = 0 of 28 (0.0 percent)] in the absence of other risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CLINICAL QUESTION\/LEVEL OF EVIDENCE:<\/jats:title>\n            <jats:p>Risk, II.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/prs.0000000000007159","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T01:01:44Z","timestamp":1600736504000},"page":"859-862","source":"Crossref","is-referenced-by-count":8,"title":["Thresholds for Safety of Cleft Lip Surgery in Premature Infants"],"prefix":"10.1097","volume":"146","author":[{"given":"Christopher L.","family":"Kalmar","sequence":"first","affiliation":[{"name":"From the Division of Plastic and Reconstructive Surgery, Children\u2019s Hospital of Philadelphia; and the Department of Head and Neck Surgery, Penn State Health."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay A.","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Division of Plastic and Reconstructive Surgery, Children\u2019s Hospital of Philadelphia; and the Department of Head and Neck Surgery, Penn State Health."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Humphries","sequence":"additional","affiliation":[{"name":"From the Division of Plastic and Reconstructive Surgery, Children\u2019s Hospital of Philadelphia; and the Department of Head and Neck Surgery, Penn State Health."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giap H.","family":"Vu","sequence":"additional","affiliation":[{"name":"From the Division of Plastic and Reconstructive Surgery, Children\u2019s Hospital of Philadelphia; and the Department of Head and Neck Surgery, Penn State Health."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie E.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"From the Division of Plastic and Reconstructive Surgery, Children\u2019s Hospital of Philadelphia; and the Department of Head and Neck Surgery, Penn State Health."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan W.","family":"Swanson","sequence":"additional","affiliation":[{"name":"From the Division of Plastic and Reconstructive Surgery, Children\u2019s Hospital of Philadelphia; and the Department of Head and Neck Surgery, Penn State Health."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"From the Division of Plastic and Reconstructive Surgery, Children\u2019s Hospital of Philadelphia; and the Department of Head and Neck Surgery, Penn State Health."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"R1-20231109","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/00006534-198706000-00004","article-title":"Early repair and breast-feeding for infants with cleft lip.","volume":"79","author":"Weatherley-White","year":"1987","journal-title":"Plast Reconstr Surg"},{"key":"R2-20231109","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bja\/61.3.263","article-title":"Complications related to anaesthesia in infants and children: A prospective survey of 40240 anaesthetics.","volume":"61","author":"Tiret","year":"1988","journal-title":"Br J Anaesth"},{"key":"R3-20231109","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1213\/00000539-199610000-00008","article-title":"A comparative study of early postoperative hypoxemia in infants, children, and adults undergoing elective plastic surgery.","volume":"83","author":"Xue","year":"1996","journal-title":"Anesth Analg"},{"key":"R4-20231109","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00000542-198704000-00006","article-title":"Postoperative apnea in preterm infants.","volume":"66","author":"Kurth","year":"1987","journal-title":"Anesthesiology"},{"key":"R5-20231109","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/1055665617726531","article-title":"Hospitalization outcomes of cleft lip repair in neonates across the United States.","volume":"55","author":"Lee","year":"2018","journal-title":"Cleft Palate Craniofac J"},{"key":"R6-20231109","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.ijporl.2006.06.004","article-title":"Early repair for infants with cleft lip and nose.","volume":"70","author":"McHeik","year":"2006","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"R7-20231109","first-page":"223","article-title":"Complications of cleft lip surgery.","volume":"3","author":"Wilhelmsen","year":"1966","journal-title":"Cleft Palate J"}],"container-title":["Plastic &amp; Reconstructive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PRS.0000000000007159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T22:02:04Z","timestamp":1699567324000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/PRS.0000000000007159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/prs.0000000000007159","relation":{},"ISSN":["0032-1052"],"issn-type":[{"value":"0032-1052","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,22]]}}}