{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:34:54Z","timestamp":1773304494582,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Studies on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) are trying to optimize medical and surgical treatments for early and advanced stages of this disease. The aim of this article is to share the experience gathered on the authors\u2019 prospectively collected 46 well-documented cases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Italian physicians are obliged to report BIA-ALCL cases to the Italian Ministry of Health. Because of this cooperation with health care professionals, the competent authority has coordinated and centralized the collection of information for each patient in 46 cases of BIA-ALCL. Statistical analyses with cumulative incidence and corresponding 95 percent confidence interval are provided for each year, dividing the number of new cases that occurred in a defined year and the population at risk of experiencing BIA-ALCL during the same year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The mean time to the onset of symptoms is reduced to 6.4 \u00b1 3.77 years (range, 1 to 22 years). Increased knowledge has also shortened the average time to diagnosis, at 7.2 \u00b1 3.71 years (range, 2 to 22 years). A late seroma appears in 91 percent of cases. The patient who died underwent limited surgery. The Italian incidence has been estimated as 2.8 per 100,000 patients receiving implants (95 percent CI, 0.88 to 4.84) in 2015; 2.1 (95 percent CI, 0.43 to 3.86) in 2016; 3.2 (95 percent CI, 1.11 to 5.31) in 2017; and 3.5 (95 percent CI, 1.36 to 5.78) in 2018.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Although the number of cases has risen slightly, BIA-ALCL is still a rare disease with a stable incidence, easily recognized and with a favorable prognosis also in advanced stages if complete surgical excision is performed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/prs.0000000000007240","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T21:16:14Z","timestamp":1598476574000},"page":"530e-538e","source":"Crossref","is-referenced-by-count":18,"title":["The Crucial Role of Surgical Treatment in BIA-ALCL Prognosis in Early- and Advanced-Stage Patients"],"prefix":"10.1097","volume":"146","author":[{"given":"Antonella","family":"Campanale","sequence":"first","affiliation":[{"name":"From the Directorate General of Medical Devices and Pharmaceutical Services, Medical Device Vigilance System and Inspections, and the Directorate General of Digitalization, Health Informative System and Statistics, Italian Ministry of Health; and the Department of Public Health and Infectious Diseases, Sapienza University of Rome."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Spagnoli","sequence":"additional","affiliation":[{"name":"From the Directorate General of Medical Devices and Pharmaceutical Services, Medical Device Vigilance System and Inspections, and the Directorate General of Digitalization, Health Informative System and Statistics, Italian Ministry of Health; and the Department of Public Health and Infectious Diseases, Sapienza University of Rome."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Lispi","sequence":"additional","affiliation":[{"name":"From the Directorate General of Medical Devices and Pharmaceutical Services, Medical Device Vigilance System and Inspections, and the Directorate General of Digitalization, Health Informative System and Statistics, Italian Ministry of Health; and the Department of Public Health and Infectious Diseases, Sapienza University of Rome."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria","family":"Boldrini","sequence":"additional","affiliation":[{"name":"From the Directorate General of Medical Devices and Pharmaceutical Services, Medical Device Vigilance System and Inspections, and the Directorate General of Digitalization, Health Informative System and Statistics, Italian Ministry of Health; and the Department of Public Health and Infectious Diseases, Sapienza University of Rome."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Marletta","sequence":"additional","affiliation":[{"name":"From the Directorate General of Medical Devices and Pharmaceutical Services, Medical Device Vigilance System and Inspections, and the Directorate General of Digitalization, Health Informative System and Statistics, Italian Ministry of Health; and the Department of Public Health and Infectious Diseases, Sapienza University of Rome."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"R1-20230801","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid 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