{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:54:58Z","timestamp":1793271298389,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Despite reports demonstrating feasibility of immediate dental implant placement in mandibular reconstruction with free fibula flaps for benign disease, this practice is not routinely used in the oncologic setting. The authors aim to demonstrate the safety of immediate dental implant placement for oncologic mandible reconstruction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>In 2017, the authors\u2019 center began immediate dental implant placement in free fibula flaps for oncologic patients undergoing mandibulectomy reconstruction. Immediate dental implant placement patients were compared to a historical cohort also reconstructed with computer-aided design and manufacturing technology beginning in 2011 (<jats:italic toggle=\"yes\">n<\/jats:italic> = 34) as a noninferiority study design. Primary outcomes of interest included 90-day complications, time to radiotherapy, and time to and number of patients achieving dental restoration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Sixty-one patients underwent free fibula flaps following mandibulectomy using computer-aided design and manufacturing. Seventy-two dental implants were placed in the immediate dental implant placement cohort (<jats:italic toggle=\"yes\">n<\/jats:italic> = 27). No differences were noted in major or minor 90-day complications between groups (<jats:italic toggle=\"yes\">p<\/jats:italic> &gt; 0.05). Radiotherapy was required in 55 percent in the immediate dental implant placement cohort versus 62 percent in the historical cohort, with no significant difference in time to radiotherapy (67.6 days versus 62.2 days, respectively). One dental implant was removed for nonosseointegration noted during vestibuloplasty. Fourteen (51.8 percent) immediate dental implant patients had complete dental restoration at 90 days compared with none in the historical cohort (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Immediate dental implant placement is a safe procedure with an unchanged short-term complication profile and no delay in radiotherapy initiation. Patients undergoing immediate dental implant placement are more likely to complete full dental rehabilitation. Long-term and health-related quality-of-life outcomes remain to be determined.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CLINICAL QUESTION\/LEVEL OF EVIDENCE:<\/jats:title>\n            <jats:p>Therapeutic, III.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/prs.0000000000007352","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T10:03:45Z","timestamp":1599991425000},"page":"768e-776e","source":"Crossref","is-referenced-by-count":41,"title":["Short-Term Outcomes following Virtual Surgery\u2013Assisted Immediate Dental Implant Placement in Free Fibula Flaps for Oncologic Mandibular Reconstruction"],"prefix":"10.1097","volume":"146","author":[{"given":"Robert J.","family":"Allen","sequence":"first","affiliation":[{"name":"From the Department of Surgery, Plastic and Reconstructive Surgery Service, Head and Neck Surgery Service, and Dental Service, Memorial Sloan Kettering Cancer Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Plastic and Reconstructive Surgery Service, Head and Neck Surgery Service, and Dental Service, Memorial Sloan Kettering Cancer Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais O.","family":"Polanco","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Plastic and Reconstructive Surgery Service, Head and Neck Surgery Service, and Dental Service, Memorial Sloan Kettering Cancer Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghana G.","family":"Shamsunder","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Plastic and Reconstructive Surgery Service, Head and Neck Surgery Service, and Dental Service, Memorial Sloan Kettering Cancer Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Ganly","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Plastic and Reconstructive Surgery Service, Head and Neck Surgery Service, and Dental Service, Memorial Sloan Kettering Cancer Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Boyle","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Plastic and Reconstructive Surgery Service, Head and Neck Surgery Service, and Dental Service, Memorial Sloan Kettering Cancer Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Rosen","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Plastic and Reconstructive Surgery Service, Head and Neck Surgery Service, and Dental Service, Memorial Sloan Kettering Cancer Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Matros","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Plastic and Reconstructive Surgery Service, Head and Neck Surgery Service, and Dental Service, Memorial Sloan Kettering Cancer Center."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"R1-20231017","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1054\/jcms.2001.0273","article-title":"Importance-rating using the University of Washington quality of life questionnaire in patients treated by primary surgery for oral and oro-pharyngeal cancer.","volume":"30","author":"Rogers","year":"2002","journal-title":"J Craniomaxillofac Surg"},{"key":"R2-20231017","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.oraloncology.2010.02.021","article-title":"Quality of life perspectives in patients with oral 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