{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:15:31Z","timestamp":1790464531789,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Posttraumatic facial paralysis is a disabling condition. Current surgical management by faciofacial nerve suture provides limited recovery. To improve the outcome, the authors evaluated an add-on strategy based on a syngeneic transplantation of nasal olfactory stem cells in a rat model of facial nerve injury. The main readouts of the study were the recording of whisking function and buccal synkinesis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Sixty rats were allocated to three groups. Animals with a 2-mm facial nerve loss were repaired with a femoral vein, filled or not with olfactory stem cells. These two groups were compared to similarly injured rats but with a faciofacial nerve suture. Olfactory stem cells were purified from rat olfactory mucosa. Three months after surgery, facial motor performance was evaluated using video-based motion analysis and electromyography. Synkinesis was assessed by electromyography, using measure of buccal involuntary movements during blink reflex, and double retrograde labeling of regenerating motoneurons.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The authors\u2019 study reveals that olfactory stem cell transplantation induces functional recovery in comparison to nontransplanted and faciofacial nerve suture groups. They significantly increase (1) maximal amplitude of vibrissae protraction and retraction cycles and (2) angular velocity during protraction of vibrissae. They also reduce buccal synkinesis, according to the two techniques used. However, olfactory stem cell transplantation did not improve axonal regrowth of the facial nerve, 3 months after surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The authors show here that the adjuvant strategy of syngeneic transplantation of olfactory stem cells improves functional recovery. These promising results open the way for a phase I clinical trial based on the autologous engraftment of olfactory stem cells in patients with a facial nerve paralysis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/prs.0000000000007367","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T06:10:47Z","timestamp":1606198247000},"page":"1295-1305","source":"Crossref","is-referenced-by-count":19,"title":["Syngeneic Transplantation of Rat Olfactory Stem Cells in a Vein Conduit Improves Facial Movements and Reduces Synkinesis after Facial Nerve Injury"],"prefix":"10.1097","volume":"146","author":[{"given":"Fanny","family":"Bense","sequence":"first","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Montava","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Duclos","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Bisson","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Delarue","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas Bon","family":"Mardion","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Boyer","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"F\u00e9ron","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gu\u00e9rout","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Marie","sequence":"additional","affiliation":[{"name":"From the Institute for Research and Innovation in Biomedicine and the Department of Immunology and Biotherapy, Normandie University; the Department of Otorhinolaryngology and Head Neck Surgery, Rouen University Hospital; the Department Otorhinolaryngology and Head Neck Surgery, Conception University Hospital; Aix Marseille University, INP, CNRS UMR 7051; and APHM, Culture and Cell Therapy Laboratory."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"issue":"Suppl 4","key":"R1-20231017","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.injury.2008.08.029","article-title":"Artificial nerve tubes and their application for repair of peripheral nerve injury: An update of current concepts.","volume":"39","author":"Ichihara","year":"2008","journal-title":"Injury"},{"key":"R2-20231017","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/dvdy.20360","article-title":"Multipotent stem cells from adult olfactory mucosa.","volume":"233","author":"Murrell","year":"2005","journal-title":"Dev 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