{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:36:40Z","timestamp":1791409000756,"version":"4.3.3"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1097\/psy.0000000000000052","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T14:07:21Z","timestamp":1399903641000},"page":"277-284","source":"Crossref","is-referenced-by-count":77,"title":["The Effects of Environmental Enrichment on Depressive and Anxiety-Relevant Behaviors in Socially Isolated Prairie Voles"],"prefix":"10.1097","volume":"76","author":[{"given":"Angela J.","family":"Grippo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Ihm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Wardwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"McNeal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa-Ann L.","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre A.","family":"Moenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle L.","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan A.","family":"LaRocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Preihs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210213","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1751-9004.2011.00342.x","article-title":"The utility of animal models in understanding links between psychosocial processes and cardiovascular health.","volume":"5","author":"Grippo","year":"2011","journal-title":"Soc Pers Psychol Compass"},{"key":"R2-6-20210213","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neubiorev.2009.09.003","article-title":"Close relationships, inflammation, and health.","volume":"35","author":"Kiecolt-Glaser","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"R3-6-20210213","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1749-6632.2010.05858.x","article-title":"Social neuroscience: challenges and opportunities in the study of complex behavior.","volume":"1224","author":"Cacioppo","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"R4-6-20210213","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0091-3057(02)00781-5","article-title":"Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats.","volume":"73","author":"Kalinichev","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"R5-6-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnint.2012.00051","article-title":"Decoding the invisible forces of social connections.","volume":"6","author":"Cacioppo","year":"2012","journal-title":"Front Integr Neurosci"},{"key":"R6-6-20210213","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/PSY.0b013e31829de2e7","article-title":"An empirical review of the neural underpinnings of receiving and giving social support: implications for health.","volume":"75","author":"Eisenberger","year":"2013","journal-title":"Psychosom Med"},{"issue":"Suppl 3","key":"R7-6-20210213","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1353\/pbm.2003.0049","article-title":"Social isolation and health, with an emphasis on underlying mechanisms.","volume":"46","author":"Cacioppo","year":"2003","journal-title":"Perspect Biol Med"},{"key":"R8-6-20210213","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/PSY.0b013e3181656e09","article-title":"Social networks and incident stroke among women with suspected myocardial ischemia.","volume":"70","author":"Rutledge","year":"2008","journal-title":"Psychosom Med"},{"key":"R9-6-20210213","first-page":"375","article-title":"Can we improve our physical health by altering our social networks Perspect Psychol S","volume":"4","author":"Cohen","year":"2009","journal-title":"ci"},{"key":"R10-6-20210213","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1073\/pnas.1219686110","article-title":"Social isolation, loneliness, and all-cause mortality in older men and women.","volume":"110","author":"Steptoe","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"R11-6-20210213","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.physbeh.2012.01.022","article-title":"Social defeat and isolation induce clear signs of a depression-like state, but modest cardiac alterations in wild-type rats.","volume":"106","author":"Carnevali","year":"2012","journal-title":"Physiol Behav"},{"key":"R12-6-20210213","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/B978-012532104-4\/50006-8","article-title":"The neurobiology of social affiliation and pair bonding.","volume":"1","author":"Carter","year":"2002","journal-title":"Horm Brain Behav"},{"key":"R13-6-20210213","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/nn1327","article-title":"The neurobiology of pair bonding.","volume":"7","author":"Young","year":"2004","journal-title":"Nat Neurosci"},{"key":"R14-6-20210213","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/npp.2008.154","article-title":"The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent.","volume":"34","author":"Bosch","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"R15-6-20210213","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.1002\/da.20375","article-title":"Social isolation in prairie voles induces behaviors relevant to negative affect: toward the development of a rodent model focused on co-occurring depression and anxiety.","volume":"25","author":"Grippo","year":"2008","journal-title":"Depress Anxiety"},{"key":"R16-6-20210213","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.biopsych.2007.04.011","article-title":"Social isolation disrupts autonomic regulation of the heart and influences negative affective behaviors.","volume":"62","author":"Grippo","year":"2007","journal-title":"Biol Psychiatry"},{"key":"R17-6-20210213","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.autneu.2010.03.003","article-title":"Cardiac dysfunction and hypothalamic activation during a social crowding stressor in prairie voles.","volume":"156","author":"Grippo","year":"2010","journal-title":"Auton Neurosci"},{"key":"R18-6-20210213","first-page":"306","article-title":"The effects of early experience on problem-solving at maturity.","volume":"2","author":"Hebb","year":"1947","journal-title":"Am Psychol"},{"key":"R20-6-20210213","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2007.11.004","article-title":"Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum.","volume":"89","author":"Brenes","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"R21-6-20210213","first-page":"1","article-title":"Enriched environment experience overcomes learning deficits and depressive-like behavior induced by juvenile stress.","volume":"4","author":"Ilin","year":"2009","journal-title":"Stress"},{"key":"R22-6-20210213","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1523\/JNEUROSCI.5080-04.2005","article-title":"Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimers disease.","volume":"25","author":"Jankowsky","year":"2005","journal-title":"J Neurosci"},{"key":"R23-6-20210213","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system.","volume":"7","author":"Nithianantharajah","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"R24-6-20210213","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment.","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat Rev Neurosci"},{"key":"R25-6-20210213","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1037\/a0033010","article-title":"Environmental enrichment as an effective treatment for autism: a randomized controlled trial.","volume":"127","author":"Woo","year":"2013","journal-title":"Behav Neurosci"},{"key":"R26-6-20210213","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1038\/tp.2012.58","article-title":"Environmental enrichment rescues female-specific hyperactivity of the hypothalamic-pituitary-adrenal axis in a model of Huntingtons disease.","volume":"2","author":"Du","year":"2012","journal-title":"Transl Psychiatry"},{"key":"R27-6-20210213","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbr.2010.06.030","article-title":"Early social enrichment provided by communal nest increases resilience to depression-like behavior more in female than male mice.","volume":"215","author":"DAndrea","year":"2010","journal-title":"Behav Brain Res"},{"key":"R28-6-20210213","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.psyneuen.2012.10.003","article-title":"Environmental enrichment influences brain cytokine variations elicited by social defeat in mice.","volume":"38","author":"McQuaid","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"R29-6-20210213","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0006-8993(78)90340-2","article-title":"Social grouping cannot account for cerebral effects of enriched environments.","volume":"153","author":"Rosenzweig","year":"1978","journal-title":"Brain Res"},{"key":"R30-6-20210213","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12017-008-8029-y","article-title":"Exercise, learned helplessness, and the stress-resistant brain.","volume":"10","author":"Greenwood","year":"2008","journal-title":"Neuromolecular Med"},{"key":"R31-6-20210213","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.bbr.2011.03.013","article-title":"The effects of environmental enrichment in the chick anxiety-depression model.","volume":"221","author":"Kim","year":"2011","journal-title":"Behav Brain Res"},{"key":"R32-6-20210213","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/dneu.20322","article-title":"Exposure to environmental enrichment elicits differential hippocampal cell proliferation: role of individual responsiveness to anxiety.","volume":"67","author":"Leal-Galicia","year":"2007","journal-title":"Dev Neurobiol"},{"key":"R33-6-20210213","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3758\/s13415-012-0101-2","article-title":"A glass full of optimism: Enrichment effects on cognitive bias in a rat model of depression.","volume":"12","author":"Richter","year":"2012","journal-title":"Cogn Affect Behav Neurosci"},{"key":"R34-6-20210213","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ab.21481","article-title":"Environmental enrichment improves novel object recognition and enhances agonistic behavior in male mice.","volume":"39","author":"Mesa-Gresa","year":"2013","journal-title":"Aggress Behav"},{"key":"R35-6-20210213","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbr.2006.07.007","article-title":"Environmental enrichment effects in social investigation in rats are gender dependent.","volume":"174","author":"Pena","year":"2006","journal-title":"Behav Brain Res"},{"key":"R36-6-20210213","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1523\/JNEUROSCI.0577-11.2011","article-title":"Environmental enrichment confers stress resiliency to social defeat through an infralimbic cortex-dependent neuroanatomical pathway.","volume":"31","author":"Lehmann","year":"2011","journal-title":"J Neurosci"},{"key":"R37-6-20210213","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1017\/S1461145712000120","article-title":"The differential impact of social defeat on mice living in isolation or groups in an enriched environment: plasma corticosterone and monoamine variations.","volume":"16","author":"McQuaid","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"R38-6-20210213","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbr.2005.04.009","article-title":"Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat.","volume":"163","author":"Leggio","year":"2005","journal-title":"Behav Brain Res"},{"key":"R39-6-20210213","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/dev.20077","article-title":"Variability in spontaneous maternal behavior is associated with anxiety-like behavior and affiliation in naive juvenile and adult female prairie voles (Microtus ochrogaster).","volume":"47","author":"Olazabal","year":"2005","journal-title":"Dev Psychobiol"},{"key":"R40-6-20210213","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","article-title":"Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test.","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"R41-6-20210213","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.","volume":"14","author":"Pellow","year":"1985","journal-title":"J Neurosci Methods"},{"key":"R42-6-20210213","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00360-006-0133-4","article-title":"Metabolic stress suppresses humoral immune function in long-day, but not short-day Siberian hamsters (Phodopus sungorus).","volume":"177","author":"Zysling","year":"2007","journal-title":"J Comp Physiol"},{"key":"R43-6-20210213","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.yhbeh.2006.08.004","article-title":"Social environment regulates corticotropin releasing factor, corticosterone and vasopressin in juvenile prairie voles.","volume":"51","author":"Ruscio","year":"2007","journal-title":"Horm Behav"},{"key":"R44-6-20210213","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.psyneuen.2007.07.004","article-title":"Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles.","volume":"32","author":"Grippo","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"R45-6-20210213","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.autneu.2013.10.001","article-title":"Disruption of social bonds induces behavioral and physiological dysregulation in male and female prairie voles.","volume":"180","author":"McNeal","year":"2014","journal-title":"Auton Neurosci"},{"key":"R46-6-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0005523","article-title":"Nest making and oxytocin comparably promote wound healing in isolation reared rats.","volume":"4","author":"Vitalo","year":"2009","journal-title":"PLoS One"},{"key":"R47-6-20210213","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.pbb.2011.12.017","article-title":"Effects of sertraline on behavioral alterations caused by environmental enrichment and social isolation.","volume":"101","author":"Yildirim","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"R48-6-20210213","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.psyneuen.2009.05.017","article-title":"Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation.","volume":"34","author":"Grippo","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"R49-6-20210213","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s10880-008-9105-z","article-title":"Exercise and depression: a review of reviews.","volume":"15","author":"Daley","year":"2008","journal-title":"J Clin Psychol Med Settings"},{"key":"R50-6-20210213","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1001\/archinternmed.2011.696","article-title":"Effect of exercise training on depressive symptoms among patients with a chronic illness: a systematic review and meta-analysis of randomized controlled trials.","volume":"172","author":"Herring","year":"2012","journal-title":"Arch Intern Med"},{"key":"R51-6-20210213","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1586\/ern.12.73","article-title":"Exploring exercise as an avenue for the treatment of anxiety disorders.","volume":"12","author":"De Boer","year":"2012","journal-title":"Expert Rev Neurother"},{"key":"R52-6-20210213","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1037\/h0045518","article-title":"Effects of neonatal cortical lesions and early environmental factors in adult rat behavior.","volume":"57","author":"Schwartz","year":"1964","journal-title":"J Comp Physiol Psychol"},{"key":"R53-6-20210213","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pneurobio.2004.03.001","article-title":"Recovery from brain injury in animals: relative efficacy of environmental enrichment, physical exercise or formal training (1990-2002).","volume":"72","author":"Will","year":"2004","journal-title":"Prog Neurobiol"},{"key":"R54-6-20210213","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/hipo.20157","article-title":"Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways.","volume":"16","author":"Olson","year":"2006","journal-title":"Hippocampus"}],"container-title":["Psychosomatic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/PSY.0000000000000052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T05:37:36Z","timestamp":1620970656000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006842-201405000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1097\/psy.0000000000000052","relation":{},"ISSN":["0033-3174"],"issn-type":[{"value":"0033-3174","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}