{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:12:37Z","timestamp":1763017957369},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychosom Med"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Chronic pain is a major problem in clinical medicine and public health, affecting approximately one in five adults, and is associated with significant societal and familial burden. Early-life adversities, psychological, and biobehavioral factors are associated with an elevated risk of the subsequent development of chronic pain. In this special issue of <jats:italic toggle=\"yes\">Psychosomatic Medicine<\/jats:italic>, articles address the neuroscientific, psychological, and biobehavioral processes involved in acute and chronic pain. We focus on the following themes that emerged in this special issue: (<jats:italic toggle=\"yes\">a<\/jats:italic>) risk factors and early adversity as related to chronic pain; (<jats:italic toggle=\"yes\">b<\/jats:italic>) the role of expectations in shaping pain perception; and (<jats:italic toggle=\"yes\">c<\/jats:italic>) mechanisms of interventions targeting pain modulation. This article concludes by outlining important new targets for research, including the neurobiology of pain, important methodological challenges, and targets for personalized pain interventions.<\/jats:p>","DOI":"10.1097\/psy.0000000000000642","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T06:05:14Z","timestamp":1541225114000},"page":"788-790","source":"Crossref","is-referenced-by-count":7,"title":["The Neuroscience of Pain: Biobehavioral, Developmental, and Psychosocial Mechanisms Relevant to Intervention Targets"],"prefix":"10.1097","volume":"80","author":[{"given":"Lauren 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