{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:21:59Z","timestamp":1775841719639,"version":"3.50.1"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychosom Med"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>The aim of the study was to examine the association of lifetime maternal depression with regulation of immune responses in the infant, measured by cytokine levels and lymphocyte proliferation (LP) in cord blood mononuclear cells collected at delivery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We studied women recruited in early pregnancy into the Project Viva longitudinal cohort who had cord blood assayed after delivery (<jats:italic toggle=\"yes\">N<\/jats:italic> = 463). Women reported about depressive symptoms in midpregnancy (Edinburgh Postnatal Depression Scale) and depression history by questionnaire. Immune responses were assayed by an index of LP, and concentrations of five cytokines (interleukin [IL]-6, IL-10, IL-13, tumor necrosis tumor necrosis factor factor \u03b1, and interferon \u03b3) after incubation of cord blood mononuclear cells either in medium alone or stimulated with phytohemagglutinin (PHA), cockroach extract, or house dust mite extract. We examined associations of maternal depression with these sets of cytokine measures using multivariable linear or tobit regression analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>After adjustment for confounders (mother's age, race\/ethnicity, education, household income, season of birth, and child sex), levels of IL-10 after stimulation with cockroach or dust mite allergen were lower in cord blood from ever versus never depressed women, and a similar trend was evident in IL-10 stimulated with PHA (percentage difference: cockroach extract = \u221241.4, <jats:italic toggle=\"yes\">p<\/jats:italic> = .027; house dust mite extract = 1\u201336.0, <jats:italic toggle=\"yes\">p<\/jats:italic> = .071; PHA = \u221224.2, <jats:italic toggle=\"yes\">p<\/jats:italic> = .333). No significant differences were seen in levels of other cytokines or LP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Maternal depression is associated with offspring immune responses at birth, which may have implications for later life atopic risk or immune function.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/psy.0000000000000686","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T20:58:27Z","timestamp":1551387507000},"page":"320-327","source":"Crossref","is-referenced-by-count":18,"title":["Prenatal Maternal Depression and Neonatal Immune Responses"],"prefix":"10.1097","volume":"81","author":[{"given":"Jill","family":"Hahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane R.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent A.","family":"Coull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie C.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia W.","family":"Finn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet W.","family":"Rich-Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheryl L.","family":"Rifas Shiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura D.","family":"Kubzansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20230825","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/S0140-6736(14)61276-9","article-title":"Non-psychotic mental disorders in the perinatal period","volume":"384","year":"2014","journal-title":"Lancet."},{"key":"bib2-20230825","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpobgyn.2013.09.002","article-title":"Perinatal mental illness: definition, description and aetiology","volume":"28","year":"2014","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"bib3-20230825","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuroscience.2015.09.001","article-title":"Untreated depression during pregnancy: short- and long-term effects in offspring. A systematic review","volume":"342","year":"2017","journal-title":"Neuroscience"},{"key":"bib4-20230825","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/all.12762","article-title":"Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies","volume":"71","year":"2016","journal-title":"Allergy"},{"key":"bib5-20230825","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.psyneuen.2015.08.019","article-title":"Prenatal stress, development, health and disease risk: a psychobiological perspective-2015 Curt Richter Award Paper","volume":"62","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"bib6-20230825","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jpsychires.2009.05.010","article-title":"Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression","volume":"43","year":"2009","journal-title":"J Psychiatr Res"},{"key":"bib7-20230825","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation","volume":"420","year":"2002","journal-title":"Nature"},{"key":"bib8-20230825","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: a social signal transduction theory of depression","volume":"140","year":"2014","journal-title":"Psychol Bull"},{"key":"bib9-20230825","first-page":"1","article-title":"Neurotrophins and neuroinflammation in fetuses exposed to maternal depression and anxiety disorders during pregnancy: a comparative study on cord blood","year":"2017","journal-title":"Arch Womens Ment Health"},{"key":"bib10-20230825","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bbi.2006.08.006","article-title":"Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy","volume":"21","year":"2007","journal-title":"Brain Behav Immun"},{"key":"bib11-20230825","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/01.psy.0000170331.74960.ad","article-title":"Prenatal stress alters cytokine levels in a manner that may endanger human pregnancy","volume":"67","year":"2005","journal-title":"Psychosom Med"},{"key":"bib12-20230825","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s40610-016-0030-x","article-title":"Prenatal maternal stress and epigenetics: review of the human research","volume":"2","year":"2016","journal-title":"Curr Mol Biol Rep"},{"key":"bib14-20230825","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1600-0897.2011.01081.x","article-title":"Negative emotions and cytokines in maternal and cord serum at preterm birth","volume":"67","year":"2012","journal-title":"Am J Reprod Immunol"},{"key":"bib15-20230825","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bbi.2008.12.004","article-title":"Maternal mood scores in mid-pregnancy are related to aspects of neonatal immune function","volume":"23","year":"2009","journal-title":"Brain Behav Immun"},{"key":"bib16-20230825","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1001\/archpsyc.1997.01830230023003","article-title":"Natural history of Diagnostic Interview Schedule\/DSM-IV major depression: the Baltimore epidemiologic catchment area follow-up","volume":"54","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"bib17-20230825","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"bib18-20230825","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1001\/archpsyc.65.4.409","article-title":"Elevated inflammation levels in depressed adults with a history of childhood maltreatment","volume":"65","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"bib19-20230825","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1128\/cdli.1.3.261-268.1994","article-title":"In vitro cytokine production by normal human peripheral blood mononuclear cells as a measure of immunocompetence or the state of activation","volume":"1","year":"1994","journal-title":"Clin Diagn Lab Immunol"},{"key":"bib20-20230825","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1081-1206(10)60912-X","article-title":"Prenatal, perinatal, and heritable influences on cord blood immune responses","volume":"96","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"bib21-20230825","doi-asserted-by":"crossref","first-page":"e401","DOI":"10.1542\/peds.2009-3226","article-title":"Maternal prenatal anxiety and stress predict infant illnesses and health complaints","volume":"126","year":"2010","journal-title":"Pediatrics"},{"key":"bib22-20230825","first-page":"37","article-title":"Cohort profile: Project Viva","volume":"44","year":"2014","journal-title":"Int J Epidemiol"},{"key":"bib23-20230825","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1192\/bjp.150.6.782","article-title":"Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale","volume":"150","year":"1987","journal-title":"Br J Psychiatry"},{"key":"bib24-20230825","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jad.2012.02.037","article-title":"Repeat testing on the Edinburgh Depression Scale and the HADS-A in pregnancy: differentiating between transient and enduring distress","volume":"141","year":"2012","journal-title":"J Affect Disord"},{"key":"bib25-20230825","doi-asserted-by":"crossref","first-page":"e319","DOI":"10.1016\/j.whi.2011.12.001","article-title":"The association between ante- and postnatal depressive symptoms and obesity in both mother and child: a systematic review of the literature","volume":"22","year":"2012","journal-title":"Womens Health Issues"},{"key":"bib26-20230825","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1136\/jech.2005.039370","article-title":"Sociodemographic predictors of antenatal and postpartum depressive symptoms among women in a medical group practice","volume":"60","year":"2006","journal-title":"J Epidemiol Community Health"},{"key":"bib27-20230825","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jaci.2005.12.1322","article-title":"Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma","volume":"117","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"bib28-20230825","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10875-005-4180-5","article-title":"Fetal cord blood: aspects of heightened immune responses","volume":"25","year":"2005","journal-title":"J Clin Immunol"},{"key":"bib29-20230825","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1128\/CDLI.8.2.303-313.2001","article-title":"Three-color flow cytometry detection of intracellular cytokines in peripheral blood mononuclear cells: comparative analysis of phorbol myristate acetate-ionomycin and phytohemagglutinin stimulation","volume":"8","year":"2001","journal-title":"Clin Diagn Lab Immunol"},{"key":"bib30-20230825","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1073\/pnas.69.6.1440","article-title":"Development of cellular immunity in the human fetus: dichotomy of proliferative and cytotoxic responses of lymphoid cells to phytohemagglutinin","volume":"69","year":"1972","journal-title":"Proc Natl Acad Sci"},{"key":"bib31-20230825","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0091-6749(99)70373-8","article-title":"Umbilical cord blood mononuclear cell proliferative response to house dust mite does not predict the development of allergic rhinitis and asthma","volume":"104","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"bib32-20230825","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1172\/JCI116526","article-title":"Analysis of T helper and antigen-presenting cell functions in cord blood and peripheral blood leukocytes from healthy children of different ages","volume":"91","year":"1993","journal-title":"J Clin Invest"},{"key":"bib33-20230825","first-page":"A14","article-title":"The vital link between chronic disease and depressive disorders","volume":"2","year":"2005","journal-title":"Prev Chronic Dis"},{"key":"bib34-20230825","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jaci.2010.12.1122","article-title":"Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study)","volume":"127","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"bib35-20230825","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.earlhumdev.2004.10.017","article-title":"The influence of the mode of delivery on circulating cytokine concentrations in the perinatal period","volume":"81","year":"2005","journal-title":"Early Hum Dev"},{"key":"bib36-20230825","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0140-6736(03)14542-4","article-title":"Association between antenatal cytokine production and the development of atopy and asthma at age 6 years","volume":"362","year":"2003","journal-title":"Lancet."},{"key":"bib37-20230825","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/sim.4067","article-title":"Multiple imputation using chained equations: issues and guidance for practice","volume":"30","year":"2011","journal-title":"Stat Med"},{"key":"bib39-20230825","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0031-9384(97)00456-3","article-title":"Prenatal stress depresses immune function in rats","volume":"63","year":"1998","journal-title":"Physiol Behav"},{"key":"bib40-20230825","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1164\/rccm.201602-0272OC","article-title":"Relationships among maternal stress and depression, type 2 responses, and recurrent wheezing at age 3 years in low-income urban families","volume":"195","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"bib41-20230825","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","year":"2012","journal-title":"Crit Rev Immunol"},{"key":"bib42-20230825","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbi.2007.05.007","article-title":"Prenatal stress, fetal imprinting and immunity","volume":"22","year":"2008","journal-title":"Brain Behav Immun"},{"key":"bib43-20230825","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/PSY.0000000000000410","article-title":"Prenatal major depressive disorder, placenta glucocorticoid and serotonergic signaling, and infant cortisol response","volume":"78","year":"2016","journal-title":"Psychosom Med"},{"key":"bib45-20230825","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ntt.2018.01.001","article-title":"The impact of prenatal insults on the human placental epigenome: a systematic review","volume":"66","year":"2018","journal-title":"Neurotoxicol Teratol"},{"key":"bib46-20230825","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4161\/epi.3.2.6034","article-title":"Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses","volume":"3","year":"2008","journal-title":"Epigenetics"},{"key":"bib47-20230825","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/npp.2011.132","article-title":"The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis","volume":"36","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"bib48-20230825","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/CIRCULATIONAHA.112.115782","article-title":"A prospective study of positive early-life psychosocial factors and favorable cardiovascular risk in adulthood","volume":"127","year":"2013","journal-title":"Circulation"},{"key":"bib49-20230825","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","year":"1990","journal-title":"Epidemiology (Cambridge, Mass)"},{"key":"bib50-20230825","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(05)66461-6","article-title":"Multiplicity in randomised trials I: endpoints and treatments","volume":"365","year":"2005","journal-title":"Lancet"},{"key":"bib51-20230825","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3945\/ajcn.115.113548","article-title":"Best (but oft-forgotten) practices: the multiple problems of multiplicity\u2014whether and how to correct for many statistical tests","volume":"102","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"bib53-20230825","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","year":"1992","journal-title":"Psychol Bull"},{"key":"bib54-20230825","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1037\/a0024895","article-title":"Preventing perinatal depression in low-income home visiting clients: a randomized controlled trial","volume":"79","year":"2011","journal-title":"J Consult Clin Psychol"},{"key":"bib55-20230825","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/da.22050","article-title":"A pilot randomized controlled trial of cognitive behavioral therapy for perinatal depression adapted for women with low incomes","volume":"30","year":"2013","journal-title":"Depress Anxiety"},{"key":"bib56-20230825","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1542\/peds.2006-0524","article-title":"Cord blood cytokines and acute lower respiratory illnesses in the first year of life","volume":"119","year":"2007","journal-title":"Pediatrics"},{"key":"bib57-20230825","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/jcpp.12187","article-title":"Annual Research Review: the neuroinflammation hypothesis for stress and psychopathology in children\u2013developmental psychoneuroimmunology","volume":"55","year":"2014","journal-title":"J Child Psychol Psychiatry"}],"container-title":["Psychosomatic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00006842-201905000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T10:39:58Z","timestamp":1692959998000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006842-201905000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1097\/psy.0000000000000686","relation":{},"ISSN":["1534-7796","0033-3174"],"issn-type":[{"value":"1534-7796","type":"electronic"},{"value":"0033-3174","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}