{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:19:15Z","timestamp":1786119555956,"version":"build-2736575974"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1097\/psy.0b013e3181f5c021","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T23:51:22Z","timestamp":1284508282000},"page":"802-809","source":"Crossref","is-referenced-by-count":35,"title":["Anxiety Increases Acid-Induced Esophageal Hyperalgesia"],"prefix":"10.1097","volume":"72","author":[{"given":"Abhishek","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Van Oudenhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Paine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasim","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20210213","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0016-5085(94)90086-8","article-title":"Basic and clinical aspects of visceral hyperalgesia.","volume":"107","author":"Mayer","year":"1994","journal-title":"Gastroenterology"},{"key":"R2-11-20210213","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1113\/jphysiol.1992.sp019069","article-title":"Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans.","volume":"448","author":"Torebjork","year":"1992","journal-title":"J Physiol Lond"},{"key":"R3-11-20210213","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/306686a0","article-title":"Evidence for a central component of post-injury pain hypersensitivity.","volume":"306","author":"Woolf","year":"1983","journal-title":"Nature"},{"key":"R4-11-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0002-9343(88)90001-0","article-title":"Chest pain: relationship of psychiatric illness to coronary arteriographic results.","volume":"84","author":"Katon","year":"1988","journal-title":"Am J Med"},{"key":"R5-11-20210213","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0022-3999(95)00065-8","article-title":"A long-term follow-up study of patients with ischaemic heart disease versus patients with nonspecific chest pain.","volume":"39","author":"Tew","year":"1995","journal-title":"J Psychosom Res"},{"key":"R6-11-20210213","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0140-6736(96)90341-4","article-title":"Psychometric scores and persistence of irritable bowel after infectious diarrhoea.","volume":"347","author":"Gwee","year":"1996","journal-title":"Lancet"},{"key":"R7-11-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-4453(94)94871-2","article-title":"Irritable bowel syndrome\u2014post salmonella infection.","volume":"29","author":"McKendrick","year":"1994","journal-title":"J Infect"},{"key":"R8-11-20210213","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/0016-5085(95)90439-5","article-title":"The sympathetic nervous system modulates perception and reflex responses to gut distention in humans.","volume":"108","author":"Iovino","year":"1995","journal-title":"Gastroenterology"},{"key":"R9-11-20210213","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1440-1746.2004.03397.x","article-title":"Autonomic responses to heartburn induced by esophageal acid infusion.","volume":"19","author":"Chen","year":"2004","journal-title":"J Gastroenterol Hepatol"},{"key":"R10-11-20210213","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/gut.49.5.706","article-title":"Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain.","volume":"49","author":"Tougas","year":"2001","journal-title":"Gut"},{"key":"R11-11-20210213","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0165-0173(92)90009-B","article-title":"Vagal afferent modulation of nociception.","volume":"17","author":"Randich","year":"1992","journal-title":"Brain Res Brain Res Rev"},{"key":"R12-11-20210213","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(94)90710-2","article-title":"Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.","volume":"257","author":"Diop","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"R13-11-20210213","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1469-8986.1995.tb01213.x","article-title":"Orienting in a defensive world: mammalian modifications of our evolutionary heritage. A polyvagal theory.","volume":"32","author":"Porges","year":"1995","journal-title":"Psychophysiology"},{"key":"R14-11-20210213","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-3999(97)00202-X","article-title":"Autonomic balance revisited: panic anxiety and heart rate variability.","volume":"44","author":"Friedman","year":"1998","journal-title":"J Psychosom Res"},{"key":"R15-11-20210213","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0140-6736(00)02758-6","article-title":"Contribution of central sensitisation to the development of non-cardiac chest pain.","volume":"356","author":"Sarkar","year":"2000","journal-title":"Lancet"},{"key":"R16-11-20210213","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1053\/j.gastro.2003.11.047","article-title":"The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor.","volume":"126","author":"Willert","year":"2004","journal-title":"Gastroenterology"},{"key":"R17-11-20210213","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1053\/j.gastro.2005.08.020","article-title":"Influence of experimentally induced anxiety on gastric sensorimotor function in humans.","volume":"129","author":"Geeraerts","year":"2005","journal-title":"Gastroenterology"},{"key":"R18-11-20210213","article-title":"Clinical Measurement in Gastroenterology. Vol 1.","author":"Barlow","year":"1997"},{"key":"R19-11-20210213","article-title":"Manual for the State-Trait Anxiety Inventory.","author":"Spielberger","year":"1970"},{"key":"R20-11-20210213","article-title":"Pictures of Facial Affect.","author":"Ekman","year":"1975"},{"issue":"Suppl 1","key":"R21-11-20210213","first-page":"47","article-title":"Functional evidence of brain stem immaturity in Rett syndrome.","volume":"6","author":"Julu","year":"1997","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"R22-11-20210213","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1113\/jphysiol.2002.036715","article-title":"Cardiovascular regulation in the period preceding vasovagal syncope in conscious humans.","volume":"549","author":"Julu","year":"2003","journal-title":"J Physiol"},{"key":"R23-11-20210213","first-page":"H758","article-title":"Real-time measurement of cardiac vagal tone in conscious dogs.","volume":"276","author":"Little","year":"1999","journal-title":"Am J Physiol"},{"key":"R24-11-20210213","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1113\/jphysiol.1976.sp011445","article-title":"Temporal response patterns of the human sinus node to brief carotid baroreceptor stimuli.","volume":"258","author":"Eckberg","year":"1976","journal-title":"J Physiol"},{"key":"R25-11-20210213","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1474-8673.1992.tb00368.x","article-title":"A linear scale for measuring vagal tone in man.","volume":"12","author":"Julu","year":"1992","journal-title":"J Auton Pharmacol"},{"key":"R26-11-20210213","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1469-8986.1992.tb01709.x","article-title":"Digital filtering: background and tutorial for psychophysiologists.","volume":"29","author":"Cook","year":"1992","journal-title":"Psychophysiology"},{"key":"R27-11-20210213","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0165-1838(96)00112-9","article-title":"A new method of assessing cardiac autonomic function and its comparison with spectral analysis and coefficient of variation of R-R interval.","volume":"62","author":"Toichi","year":"1997","journal-title":"J Auton Nerv Syst"},{"key":"R28-11-20210213","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1136\/bmj.300.6719.230","article-title":"Analysis of serial measurements in clinical research.","volume":"300","author":"Matthews","year":"1990","journal-title":"BMJ"},{"key":"R29-11-20210213","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pain.2009.02.022","article-title":"Exploring relationships for visceral and somatic pain with autonomic control and personality.","volume":"144","author":"Paine","year":"2009","journal-title":"Pain"},{"key":"R30-11-20210213","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1365-2036.2007.03411.x","article-title":"Severe gastro-oesophageal reflux symptoms in relation to anxiety, depression and coping in a population-based study.","volume":"26","author":"Jansson","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"R31-11-20210213","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/00365520500292970","article-title":"Psychological factors as a predictor of treatment response in patients with heartburn: a pooled analysis of clinical trials.","volume":"41","author":"Wiklund","year":"2006","journal-title":"Scand J Gastroenterol"},{"key":"R32-11-20210213","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2036.2007.03393.x","article-title":"Oesophageal hypersensitivity is associated with features of psychiatric disorders and the irritable bowel syndrome.","volume":"26","author":"Rubenstein","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"R33-11-20210213","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/PSY.0b013e3180600a4a","article-title":"Relationship between anxiety and gastric sensorimotor function in functional dyspepsia.","volume":"69","author":"Van Oudenhove","year":"2007","journal-title":"Psychosom Med"},{"key":"R34-11-20210213","doi-asserted-by":"crossref","first-page":"G1257","DOI":"10.1152\/ajpgi.00314.2002","article-title":"Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress.","volume":"283","author":"Soderholm","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R35-11-20210213","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1136\/gut.2006.113688","article-title":"Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces.","volume":"56","author":"Farre","year":"2007","journal-title":"Gut"},{"key":"R36-11-20210213","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1136\/gut.2007.120691","article-title":"Stress-related changes in oesophageal permeability: filling the gaps of GORD?","volume":"56","author":"Soderholm","year":"2007","journal-title":"Gut"},{"key":"R37-11-20210213","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1053\/j.gastro.2007.12.010","article-title":"The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease.","volume":"134","author":"Fass","year":"2008","journal-title":"Gastroenterology"},{"key":"R38-11-20210213","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/272826a0","article-title":"The narcotic antagonist naloxone enhances clinical pain.","volume":"272","author":"Levine","year":"1978","journal-title":"Nature"},{"key":"R39-11-20210213","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/nn966","article-title":"Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways.","volume":"5","author":"Suzuki","year":"2002","journal-title":"Nat Neurosci"},{"key":"R40-11-20210213","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/brain\/awg065","article-title":"The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation.","volume":"126","author":"Phillips","year":"2003","journal-title":"Brain"},{"key":"R41-11-20210213","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0016-5085(97)70079-9","article-title":"Identification of human brain loci processing esophageal sensation using positron emission tomography.","volume":"113","author":"Aziz","year":"1997","journal-title":"Gastroenterology"}],"container-title":["Psychosomatic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/PSY.0b013e3181f5c021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:34:16Z","timestamp":1786041256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006842-201010000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/psy.0b013e3181f5c021","relation":{},"ISSN":["0033-3174"],"issn-type":[{"value":"0033-3174","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}