{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:01:40Z","timestamp":1787702500308,"version":"build-2784847793"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1097\/qad.0b013e3282f153ed","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T18:35:52Z","timestamp":1236105352000},"page":"2283-2291","source":"Crossref","is-referenced-by-count":35,"title":["Reduced mortality and CD4 cell loss among carriers of the interleukin-10 \u22121082G allele in a Zimbabwean cohort of HIV-1-infected adults"],"prefix":"10.1097","volume":"21","author":[{"given":"Christian","family":"Erikstrup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Kallestrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutendo B","family":"Zinyama-Gutsire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Exnevia","family":"Gomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E","family":"Butterworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente K","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisse R","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gerstoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210130","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4049\/jimmunol.144.2.480","article-title":"Infection with HIV is associated with elevated IL-6 levels and production","volume":"144","author":"Breen","year":"1990","journal-title":"J Immunol"},{"key":"R2-4-20210130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0002-9343(88)90576-1","article-title":"Elevated levels of circulating cachectin\/tumor necrosis factor in patients with acquired immunodeficiency syndrome","volume":"85","author":"Lahdevirta","year":"1988","journal-title":"Am J Med"},{"key":"R3-4-20210130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1365-2249.1999.00865.x","article-title":"IL-10 in HIV infection: increasing serum IL-10 levels with disease progression \u2013 down-regulatory effect of potent antiretroviral therapy","volume":"116","author":"Stylianou","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"R4-4-20210130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0923-2516(91)90062-8","article-title":"Induction of NF-kappa B during monocyte differentiation is associated with activation of HIV-gene expression","volume":"142","author":"Griffin","year":"1991","journal-title":"Res Virol"},{"key":"R5-4-20210130","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.1128\/JVI.75.17.8195-8202.2001","article-title":"Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy","volume":"75","author":"Lane","year":"2001","journal-title":"J Virol"},{"key":"R6-4-20210130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1084\/jem.172.1.151","article-title":"Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and posttranscriptional mechanisms","volume":"172","author":"Poli","year":"1990","journal-title":"J Exp Med"},{"key":"R7-4-20210130","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1073\/pnas.87.2.782","article-title":"Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression","volume":"87","author":"Poli","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"R8-4-20210130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ni869","article-title":"Lethal T cell immunodeficiency induced by chronic costimulation via CD27\u2013CD70 interactions","volume":"4","author":"Tesselaar","year":"2003","journal-title":"Nat Immunol"},{"key":"R9-4-20210130","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1089\/aid.1994.10.1199","article-title":"Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor alpha and interleukin 6 induction of virus","volume":"10","author":"Weissman","year":"1994","journal-title":"AIDS Res Hum Retroviruses"},{"key":"R10-4-20210130","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00002030-200303070-00007","article-title":"Impaired production of cytokines is an independent predictor of mortality in HIV-1-infected patients","volume":"17","author":"Ostrowski","year":"2003","journal-title":"AIDS"},{"key":"R11-4-20210130","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/nm1492","article-title":"Interleukin-10 determines viral clearance or persistence in vivo","volume":"12","author":"Brooks","year":"2006","journal-title":"Nat Med"},{"key":"R12-4-20210130","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1084\/jem.20061462","article-title":"Resolution of a chronic viral infection after interleukin-10 receptor blockade","volume":"203","author":"Ejrnaes","year":"2006","journal-title":"J Exp Med"},{"key":"R13-4-20210130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.gene.6363645","article-title":"Cytokine gene polymorphism in human disease: on-line databases","volume":"1","author":"Bidwell","year":"1999","journal-title":"Genes Immun"},{"key":"R14-4-20210130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/sj.gene.6364301","article-title":"Cytokine gene polymorphism in human disease: on-line databases, Supplement 3","volume":"7","author":"Hollegaard","year":"2006","journal-title":"Genes Immun"},{"key":"R15-4-20210130","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/1529-0131(199906)42:6<1101::AID-ANR6>3.0.CO;2-Y","article-title":"Polymorphic haplotypes of the interleukin-10 5\u2032 flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis","volume":"42","author":"Crawley","year":"1999","journal-title":"Arthritis Rheum"},{"key":"R16-4-20210130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2370.1997.tb00001.x","article-title":"An investigation of polymorphism in the interleukin-10 gene promoter","volume":"24","author":"Turner","year":"1997","journal-title":"Eur J Immunogenet"},{"key":"R17-4-20210130","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.gene.6363920","article-title":"Differential regulation of interleukin-10 production by genetic and environmental factors: a twin study","volume":"3","author":"Reuss","year":"2002","journal-title":"Genes Immun"},{"key":"R18-4-20210130","doi-asserted-by":"crossref","first-page":"14467","DOI":"10.1073\/pnas.97.26.14467","article-title":"Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10","volume":"97","author":"Shin","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"R19-4-20210130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/1043-4666(90)90048-X","article-title":"Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans","volume":"2","author":"Lantz","year":"1990","journal-title":"Cytokine"},{"key":"R20-4-20210130","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1359-6101(96)00026-3","article-title":"The potential biological and clinical significance of the soluble tumor necrosis factor receptors","volume":"7","author":"Aderka","year":"1996","journal-title":"Cytokine Growth Factor Rev"},{"issue":"Suppl 1","key":"R21-4-20210130","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1007\/BF02390680","article-title":"Kinetics of tumour necrosis factor-alpha, soluble tumour necrosis factor receptors, interleukin 1-beta and its receptor antagonist during serious infections","volume":"13","author":"van Deuren","year":"1994","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R22-4-20210130","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1086\/428907","article-title":"Schistosomiasis and HIV-1 infection in rural Zimbabwe: implications of coinfection for excretion of eggs","volume":"191","author":"Kallestrup","year":"2005","journal-title":"J Infect Dis"},{"key":"R23-4-20210130","first-page":"227","article-title":"Field studies of a reusable polyamide filter for detection of Schistosoma haematobium eggs by urine filtration","volume":"33","author":"Mott","year":"1982","journal-title":"Tropenmed Parasitol"},{"key":"R24-4-20210130","doi-asserted-by":"crossref","first-page":"818","DOI":"10.4269\/ajtmh.1976.25.818","article-title":"A modification of the formol\u2013ether concentration technique for increased sensitivity in detecting Schistosoma mansoni eggs","volume":"25","author":"Knight","year":"1976","journal-title":"Am J Trop Med Hyg"},{"key":"R25-4-20210130","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1086\/429334","article-title":"Increased prevalence of leukocytes and elevated cytokine levels in semen from Schistosoma haematobium-infected individuals","volume":"191","author":"Leutscher","year":"2005","journal-title":"J Infect Dis"},{"key":"R26-4-20210130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/QAI.0b013e318032bbcd","article-title":"Predictors of mortality in a cohort of HIV-1-infected adults in rural Africa","volume":"44","author":"Erikstrup","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"R27-4-20210130","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1056\/NEJMoa022060","article-title":"Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation","volume":"349","author":"Lin","year":"2003","journal-title":"N Engl J Med"},{"key":"R28-4-20210130","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1164\/rccm.200210-1164OC","article-title":"Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism","volume":"168","author":"Schaaf","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"R29-4-20210130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/jmg.40.4.296","article-title":"Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha \u2212308 promoter SNP","volume":"40","author":"Lio","year":"2003","journal-title":"J Med Genet"},{"key":"R30-4-20210130","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1046\/j.1523-1755.2002.00504.x","article-title":"Anti-inflammatory interleukin-10 genotype protects dialysis patients from cardiovascular events","volume":"62","author":"Girndt","year":"2002","journal-title":"Kidney Int"},{"key":"R31-4-20210130","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1399-0039.1999.540408.x","article-title":"Interleukin-10 (IL-10) genotypes in inflammatory bowel disease","volume":"54","author":"Tagore","year":"1999","journal-title":"Tissue Antigens"},{"key":"R32-4-20210130","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1365-3083.2006.001768.x","article-title":"Plasma levels of intact and cleaved urokinase receptor decrease in HIV-1-infected patients initiating highly active antiretroviral therapy","volume":"63","author":"Ostrowski","year":"2006","journal-title":"Scand J Immunol"},{"key":"R33-4-20210130","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1128\/JVI.71.5.4150-4156.1997","article-title":"55- and 75-kilodalton tumor necrosis factor receptors mediate distinct actions in regard to human immunodeficiency virus type 1 replication in primary human macrophages","volume":"71","author":"Herbein","year":"1997","journal-title":"J Virol"},{"key":"R34-4-20210130","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/371508a0","article-title":"Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria","volume":"371","author":"McGuire","year":"1994","journal-title":"Nature"},{"key":"R35-4-20210130","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1086\/314533","article-title":"Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles","volume":"179","author":"McGuire","year":"1999","journal-title":"J Infect Dis"},{"key":"R36-4-20210130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/sj.gene.6363827","article-title":"Gender-specific association between \u22121082 IL-10 promoter polymorphism and longevity","volume":"3","author":"Lio","year":"2002","journal-title":"Genes Immun"},{"key":"R37-4-20210130","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1375\/twin.7.6.578","article-title":"Quantitative association tests of immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa","volume":"7","author":"Wiart","year":"2004","journal-title":"Twin Res"},{"key":"R38-4-20210130","doi-asserted-by":"crossref","first-page":"757","DOI":"10.7326\/0003-4819-124-8-199604150-00009","article-title":"Plasma cytokines, cytokine antagonists, and disease progression in African women infected with HIV-1","volume":"124","author":"Thea","year":"1996","journal-title":"Ann Intern Med"},{"key":"R39-4-20210130","first-page":"79","article-title":"Increased serum concentrations of soluble tumor necrosis factor receptors in HIV-infected individuals are associated with immune activation","volume":"7","author":"Zangerle","year":"1994","journal-title":"J Acquir Immune Defic Syndr"},{"key":"R40-4-20210130","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00126334-200404010-00002","article-title":"Soluble urokinase receptor levels in plasma during 5 years of highly active antiretroviral therapy in HIV-1-infected patients","volume":"35","author":"Ostrowski","year":"2004","journal-title":"J Acquir Immune Defic Syndr"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00002030-200711120-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:46:11Z","timestamp":1786038371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002030-200711120-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":40,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e3282f153ed","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}