{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:15:20Z","timestamp":1786119320668,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,20]]},"DOI":"10.1097\/qad.0b013e32830a9886","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T16:47:33Z","timestamp":1236271653000},"page":"1561-1568","source":"Crossref","is-referenced-by-count":38,"title":["Genetic analysis implicates resistin in HIV lipodystrophy"],"prefix":"10.1097","volume":"22","author":[{"given":"Koustubh","family":"Ranade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Geese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Noor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Flint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Tebas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Powderly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K","family":"Grinspoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210130","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1097\/00002030-199807000-00003","article-title":"A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors","volume":"12","author":"Carr","year":"1998","journal-title":"AIDS"},{"key":"R2-4-20210130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra041811","article-title":"Cardiovascular risk and body fat abnormalities in HIV infected individuals","volume":"352","author":"Grinspoon","year":"2005","journal-title":"N Engl J Med"},{"key":"R3-4-20210130","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1056\/NEJMoa030218","article-title":"Combination antiretroviral therapy and the risk of myocardial infarction","volume":"349","author":"Friis-Moller","year":"2003","journal-title":"N Engl J Med"},{"key":"R4-4-20210130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00002030-200001070-00006","article-title":"Effect of ritonavir on lipids and postheparin lipase activities in normal subjects","volume":"14","author":"Purnell","year":"2000","journal-title":"AIDS"},{"key":"R5-4-20210130","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/498505","article-title":"Body fat and other metabolic effects of atazanavir and efavirenz, each administered in combination with zidovudine plus lamivudine, in antiretroviral-naive HIV-infected patients","volume":"42","author":"Jemsek","year":"2006","journal-title":"Clin Infect Dis"},{"key":"R6-4-20210130","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1097\/00002030-200007070-00027","article-title":"Beta3-adrenergic receptor polymorphism and the antiretroviral therapy-related lipodystrophy syndrome","volume":"14","author":"Vonkeman","year":"2000","journal-title":"AIDS"},{"key":"R7-4-20210130","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1097\/00002030-200210180-00005","article-title":"TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy","volume":"15","author":"Maher","year":"2002","journal-title":"AIDS"},{"key":"R8-4-20210130","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1371\/journal.pmed.0030052","article-title":"Associations among race\/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapy","volume":"3","author":"Foulkes","year":"2006","journal-title":"PLoS Med"},{"key":"R9-4-20210130","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"Nature"},{"key":"R10-4-20210130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors","volume":"33","author":"Ramaswamy","year":"2003","journal-title":"Nat Genet"},{"key":"R11-4-20210130","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"R12-4-20210130","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1097\/01.aids.0000183629.20041.bb","article-title":"Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz plus dual nucleosides","volume":"19","author":"Dube","year":"2005","journal-title":"AIDS"},{"key":"R13-4-20210130","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1056\/NEJMoa030264","article-title":"Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection","volume":"349","author":"Robbins","year":"2003","journal-title":"N Engl J Med"},{"key":"R14-4-20210130","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1056\/NEJMoa030265","article-title":"Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection","volume":"349","author":"Shafer","year":"2003","journal-title":"N Engl J Med"},{"key":"R15-4-20210130","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1101\/gr.157801","article-title":"High-throughput genotyping with single nucleotide polymorphisms","volume":"11","author":"Ranade","year":"2001","journal-title":"Genome Res"},{"key":"R16-4-20210130","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1009783824328","article-title":"BIRCH: a new data clustering algorithm and its applications","volume":"1","author":"Zhang","year":"1997","journal-title":"Data Mining Knowledge Dis"},{"key":"R17-4-20210130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"R18-4-20210130","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1126\/science.7777857","article-title":"Extreme discordant sib pairs for mapping quantitative trait loci in humans","volume":"268","author":"Risch","year":"1995","journal-title":"Science"},{"key":"R19-4-20210130","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/ng1790","article-title":"A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization","volume":"38","author":"Arking","year":"2006","journal-title":"Nat Genet"},{"key":"R21-4-20210130","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/00002030-200305020-00005","article-title":"Prospective evaluation of the effects of antiretroviral therapy on body composition in HIV-1 infected men starting therapy","volume":"17","author":"Mallon","year":"2003","journal-title":"AIDS"},{"key":"R22-4-20210130","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1124\/mol.104.010165","article-title":"Endoplasmic reticulum stress links dyslipidemia to inhibition of proteasome activity and glucose transport by HIV protease inhibitors","volume":"67","author":"Parker","year":"2005","journal-title":"Mol Pharmacol"},{"key":"R23-4-20210130","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome.","volume":"437","year":"2005","journal-title":"Nature"},{"key":"R25-4-20210130","doi-asserted-by":"crossref","first-page":"18297","DOI":"10.1073\/pnas.0507432102","article-title":"Information based clustering","volume":"51","author":"Slonim","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R26-4-20210130","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1126\/science.1092341","article-title":"Regulation of fasted blood glucose by resistin","volume":"203","author":"Banerjee","year":"2004","journal-title":"Science"},{"key":"R27-4-20210130","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2337\/diabetes.51.5.1629","article-title":"5\u2032 Flanking variants of resistin are associated with obesity","volume":"51","author":"Engert","year":"2002","journal-title":"Diabetes"},{"key":"R28-4-20210130","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1210\/jcem.87.6.8528","article-title":"Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians","volume":"87","author":"Wang","year":"2002","journal-title":"J Clin Endo Metab"},{"key":"R29-4-20210130","doi-asserted-by":"crossref","first-page":"860","DOI":"10.2337\/diabetes.51.3.860","article-title":"Human resistin gene, obesity, and type 2 diabetes mutational analysis and population study","volume":"51","author":"Sentinelli","year":"2002","journal-title":"Diabetes"},{"key":"R30-4-20210130","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s00125-004-1537-x","article-title":"Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects","volume":"47","author":"Conneely","year":"2004","journal-title":"Diabetologia"},{"key":"R31-4-20210130","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/424761","article-title":"The G\/G genotype of resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1\/3","volume":"75","author":"Osawa","year":"2004","journal-title":"Am J Hum Genet"},{"key":"R32-4-20210130","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2337\/dc06-1936","article-title":"Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population","volume":"30","author":"Osawa","year":"2007","journal-title":"Diabetes Care"},{"key":"R33-4-20210130","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1732","article-title":"Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.","volume":"38","author":"Grant","year":"2006","journal-title":"Nat Genet"},{"key":"R34-4-20210130","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1182\/blood.V95.10.3191.010k10_3191_3198","article-title":"Alteration of tumor necrosis factor-a T cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus-associated lipodystrophy syndrome","volume":"95","author":"Ledru","year":"2000","journal-title":"Blood"},{"key":"R35-4-20210130","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1371\/journal.pmed.0010045","article-title":"An inflammatory cascade leading to hyperresistinemia in humans","volume":"2","author":"Lehrke","year":"2004","journal-title":"PLoS Med"},{"key":"R36-4-20210130","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/01.CIR.0000155620.10387.43","article-title":"Resistin is an inflammatory marker of atherosclerosis in humans","volume":"111","author":"Reilly","year":"2005","journal-title":"Circulation"},{"key":"R37-4-20210130","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1210\/jc.2005-0287","article-title":"Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone","volume":"90","author":"Kamin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R38-4-20210130","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1210\/jc.2005-0742","article-title":"Circulating resistin levels are not associated with fat redistribution, insulin resistance or metabolic profile in patients with the highly active antiretroviral therapy-induced metabolic syndrome","volume":"90","author":"Barb","year":"2005","journal-title":"J Clin Endocrinol Metab"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00002030-200808200-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:53:49Z","timestamp":1786038829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002030-200808200-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,20]]},"references-count":36,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e32830a9886","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8,20]]}}}