{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:30:03Z","timestamp":1793943003839,"version":"4.8.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,13]]},"DOI":"10.1097\/qad.0b013e32831f1b00","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T11:14:23Z","timestamp":1242904463000},"page":"605-610","source":"Crossref","is-referenced-by-count":32,"title":["GBV-C viremia is associated with reduced CD4 expansion in HIV-infected people receiving HAART and interleukin-2 therapy"],"prefix":"10.1097","volume":"23","author":[{"given":"Jack T","family":"Stapleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Chaloner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Klinzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inara E","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Landay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fahey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Mitsuyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20210130","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.181845","article-title":"Selective in vitro growth of T lymphocytes from normal human bone marrows","volume":"193","author":"Morgan","year":"1976","journal-title":"Science"},{"key":"R2-7-20210130","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1034\/j.1600-065X.2003.00051.x","article-title":"Activation-induced cell death in T cells","volume":"4","author":"Green","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"R3-7-20210130","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cytogfr.2006.07.003","article-title":"Both integrated and differential regulation of components of the IL-2\/IL-2 receptor system","volume":"17","author":"Kim","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"R4-7-20210130","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.6200936","article-title":"Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS","volume":"224","author":"Gallo","year":"1984","journal-title":"Science"},{"key":"R5-7-20210130","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archinte.167.6.597","article-title":"The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection: a randomized controlled clinical trial: AIDS Clinical Trials Group 328","volume":"167","author":"Mitsuyasu","year":"2007","journal-title":"Arch Intern Med"},{"key":"R6-7-20210130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1089\/jir.2007.0064","article-title":"Safety, tolerability, pharmacokinetics, and efficacy of an interleukin-2 agonist among HIV-infected patients receiving highly active antiretroviral therapy","volume":"28","author":"Davey","year":"2008","journal-title":"J Interferon Cytokine Res"},{"key":"R7-7-20210130","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.271.5248.505","article-title":"Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent","volume":"271","author":"Linnen","year":"1996","journal-title":"Science"},{"key":"R8-7-20210130","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nm0695-564","article-title":"Isolation of novel virus-like sequences associated with human hepatitis","volume":"1","author":"Simons","year":"1995","journal-title":"Nat Med"},{"key":"R9-7-20210130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-2003-39943","article-title":"GB virus type C\/hepatitis G virus","volume":"23","author":"Stapleton","year":"2003","journal-title":"Semin Liver Dis"},{"key":"R10-7-20210130","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1046\/j.1537-2995.1997.37697335149.x","article-title":"G-pers creepers, where'd you get those papers? A reassessment of the literature on the hepatitis G virus","volume":"37","author":"Alter","year":"1997","journal-title":"Transfusion"},{"key":"R11-7-20210130","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa030107","article-title":"Persistent GB virus C infection and survival in HIV-infected men","volume":"350","author":"Williams","year":"2004","journal-title":"N Engl J Med"},{"key":"R12-7-20210130","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1097\/00002030-200411190-00021","article-title":"GB virus C and survival in HIV-positive people","volume":"18","author":"Stapleton","year":"2004","journal-title":"AIDS"},{"key":"R13-7-20210130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1468-1293.2006.00366.x","article-title":"Effect of early and late GBV-C viremia on survival of HIV infected individuals: a meta-analysis","volume":"7","author":"Zhang","year":"2006","journal-title":"HIV Med"},{"key":"R14-7-20210130","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.micinf.2003.08.006","article-title":"GB virus type C\/hepatitis G virus: a nonpathogenic flavivirus associated with prolonged survival in HIV-infected individuals","volume":"5","author":"Polgreen","year":"2003","journal-title":"Microb Infect"},{"key":"R15-7-20210130","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1056\/NEJMoa010398","article-title":"Infection with GB virus C and reduced mortality among HIV-infected patients","volume":"345","author":"Tillmann","year":"2001","journal-title":"N Engl J Med"},{"key":"R16-7-20210130","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1097\/QAD.0b013e32823bc9b7","article-title":"Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART","volume":"21","author":"Bjorkman","year":"2007","journal-title":"AIDS"},{"key":"R17-7-20210130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1056\/NEJMoa003364","article-title":"Effect of coinfection with GB Virus C (hepatitis G virus) on survival among patients with HIV infection","volume":"345","author":"Xiang","year":"2001","journal-title":"N Engl J Med"},{"key":"R18-7-20210130","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/S0140-6736(04)16453-2","article-title":"Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MIP-1\u03b1, MIP-1\u03b2, and SDF-1","volume":"363","author":"Xiang","year":"2004","journal-title":"Lancet"},{"key":"R19-7-20210130","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1097\/01.aids.0000180097.50393.df","article-title":"Inhibition of HIV strains by GB virus C in cell culture can be mediated by CD4 and CD8 T-lymphocyte derived soluble factors","volume":"19","author":"Jung","year":"2005","journal-title":"AIDS"},{"key":"R20-7-20210130","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1128\/JVI.73.5.4052-4061.1999","article-title":"In vitro infection of human peripheral blood mononuclear cells by GB virus C\/hepatitis G virus","volume":"73","author":"Fogeda","year":"1999","journal-title":"J Virol"},{"key":"R21-7-20210130","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1128\/JVI.74.19.9125-9133.2000","article-title":"Full-length GB virus C (hepatitis G virus) RNA transcripts are infectious in primary CD4-positive T cells","volume":"74","author":"Xiang","year":"2000","journal-title":"J Virol"},{"key":"R22-7-20210130","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1086\/499435","article-title":"GB virus C replicates in primary T and B lymphocytes","volume":"193","author":"George","year":"2006","journal-title":"J Infect Dis"},{"key":"R23-7-20210130","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0042-6822(03)00585-3","article-title":"Clinical isolates of GB virus type C vary in their ability to persist and replicate in peripheral blood mononuclear cell cultures","volume":"316","author":"George","year":"2003","journal-title":"Virology"},{"key":"R24-7-20210130","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1128\/JCM.02663-05","article-title":"Optimal testing for GB Virus C viremia: effect of primer selection on estimates of GBV-C prevalence and response to antiretroviral therapy","volume":"44","author":"Souza","year":"2006","journal-title":"J Clin Microbiol"},{"key":"R26-7-20210130","first-page":"1039","article-title":"Statistical aspects of cancer trials","author":"Peto","year":"1995"},{"key":"R27-7-20210130","first-page":"121","article-title":"Subgroups and interactions","author":"Follman","year":"2004"},{"key":"R28-7-20210130","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1023\/A:1011059906777","article-title":"IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells","volume":"21","author":"Yang","year":"2001","journal-title":"J Clin Immunol"},{"key":"R29-7-20210130","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1073\/pnas.94.5.1925","article-title":"The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes","volume":"94","author":"Bleul","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R30-7-20210130","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1097\/00002030-200307040-00006","article-title":"Regulation of CC chemokine receptor 5 in Hepatitis G virus infection","volume":"17","author":"Nattermann","year":"2003","journal-title":"AIDS"},{"key":"R32-7-20210130","first-page":"172","article-title":"Disrupting T-cell homeostasis: how HIV-1 infection causes disease","volume":"5","author":"Douek","year":"2003","journal-title":"AIDS Rev"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00002030-200903130-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:54:18Z","timestamp":1786038858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002030-200903130-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,13]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e32831f1b00","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3,13]]}}}