{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:21:35Z","timestamp":1790864495931,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10,23]]},"DOI":"10.1097\/qad.0b013e328331567a","type":"journal-article","created":{"date-parts":[[2009,10,10]],"date-time":"2009-10-10T03:32:59Z","timestamp":1255145579000},"page":"2091-2100","source":"Crossref","is-referenced-by-count":27,"title":["Impact of novel TRIM5\u03b1 variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection"],"prefix":"10.1097","volume":"23","author":[{"given":"Toshiaki","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi E","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurvinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Terunuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ich","family":"Mimaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narinder","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Shioda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20210130","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature00939","article-title":"Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein","volume":"418","author":"Sheehy","year":"2002","journal-title":"Nature"},{"key":"R2-3-20210130","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nature02343","article-title":"The cytoplasmic body component TRIM5\u03b1 restricts HIV-1 infection in Old World monkeys","volume":"427","author":"Stremlau","year":"2004","journal-title":"Nature"},{"key":"R3-3-20210130","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1073\/pnas.0510483103","article-title":"Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection","volume":"103","author":"Wu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R4-3-20210130","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1073\/pnas.0509996103","article-title":"Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor","volume":"103","author":"Stremlau","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R5-3-20210130","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1073\/pnas.0402876101","article-title":"Trim5\u03b1 protein restricts both HIV-1 and murine leukemia virus","volume":"101","author":"Yap","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R6-3-20210130","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1128\/JVI.02318-06","article-title":"The human TRIM5\u03b1 restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid","volume":"81","author":"Perron","year":"2007","journal-title":"J Virol"},{"key":"R7-3-20210130","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2413","article-title":"TRIM family proteins and their emerging roles in innate immunity","volume":"8","author":"Ozato","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"R8-3-20210130","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1128\/JVI.79.14.8969-8978.2005","article-title":"Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity","volume":"79","author":"Perez-Caballero","year":"2005","journal-title":"J Virol"},{"key":"R9-3-20210130","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1128\/JVI.79.5.3139-3145.2005","article-title":"Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction","volume":"79","author":"Stremlau","year":"2005","journal-title":"J Virol"},{"key":"R10-3-20210130","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cub.2004.12.042","article-title":"A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction","volume":"15","author":"Yap","year":"2005","journal-title":"Curr Biol"},{"key":"R11-3-20210130","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1073\/pnas.0409853102","article-title":"Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain","volume":"102","author":"Sawyer","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R12-3-20210130","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.1128\/JVI.79.14.8870-8877.2005","article-title":"A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines species-specific restriction of simian immunodeficiency virus SIVmac infection","volume":"79","author":"Nakayama","year":"2005","journal-title":"J Virol"},{"key":"R13-3-20210130","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.virol.2007.12.022","article-title":"Comparison of antiviral activity of rhesus and cynomolgus monkey TRIM5\u03b1s against HIV-2 infection","volume":"373","author":"Kono","year":"2008","journal-title":"Virology"},{"key":"R14-3-20210130","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ng1369","article-title":"Human genes that limit AIDS","volume":"36","author":"O'Brien","year":"2004","journal-title":"Nat Genet"},{"key":"R15-3-20210130","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1086\/425269","article-title":"Influence of host genetic variation on susceptibility to HIV type 1 infection","volume":"191","author":"Kaslow","year":"2005","journal-title":"J Infect Dis"},{"key":"R16-3-20210130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cub.2005.11.045","article-title":"High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans","volume":"16","author":"Sawyer","year":"2006","journal-title":"Curr Biol"},{"key":"R17-3-20210130","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1128\/JVI.80.5.2463-2471.2006","article-title":"Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection","volume":"80","author":"Speelmon","year":"2006","journal-title":"J Virol"},{"key":"R18-3-20210130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.virol.2006.06.031","article-title":"Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection","volume":"354","author":"Javanbakht","year":"2006","journal-title":"Virology"},{"key":"R19-3-20210130","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00251-007-0217-7","article-title":"Wild type and H43Y variant of human TRIM5alpha show similar antihuman immunodeficiency virus type 1 activity both in vivo and in vitro","volume":"59","author":"Nakayama","year":"2007","journal-title":"Immunogenetics"},{"key":"R20-3-20210130","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1371\/journal.ppat.0040018","article-title":"The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection","volume":"4","author":"van Manen","year":"2008","journal-title":"PLoS Pathog"},{"key":"R21-3-20210130","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1089\/vim.2005.18.500","article-title":"HLA-B polymorphism in Japanese HIV-1 infected long-term surviving hemophiliacs","volume":"18","author":"Munkanta","year":"2005","journal-title":"Viral Immunol"},{"key":"R22-3-20210130","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00251-007-0252-4","article-title":"Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia","volume":"59","author":"Nakajima","year":"2007","journal-title":"Immunogenetics"},{"key":"R23-3-20210130","doi-asserted-by":"crossref","first-page":"7280","DOI":"10.1128\/JVI.00406-07","article-title":"A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5alphas","volume":"81","author":"Song","year":"2007","journal-title":"J Virol"},{"key":"R24-3-20210130","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jviromet.2008.04.012","article-title":"Silencing of tripartite motif protein (TRIM) 5alpha mediated anti-HIV-1 activity by truncated mutant of TRIM5alpha","volume":"151","author":"Maegawa","year":"2008","journal-title":"J Virol Methods"},{"key":"R25-3-20210130","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.virol.2009.03.004","article-title":"Impact of a single amino acid in the variable region 2 of the Old World monkey TRIM5 SPRY(B30.2) domain on antihuman immunodeficiency virus type 2 activity.","volume":"388","author":"Kono","year":"2009","journal-title":"Virology"},{"key":"R26-3-20210130","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s12038-008-0070-3","article-title":"HIV infection in India: epidemiology, molecular epidemiology and pathogenesis","volume":"33","author":"Lakhashe","year":"2008","journal-title":"J Biosci"},{"key":"R27-3-20210130","first-page":"S13","article-title":"The molecular epidemiology of HIV in Asia","volume":"8","author":"Weniger","year":"1994","journal-title":"AIDS"},{"key":"R28-3-20210130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1742-4690-3-79","article-title":"Human TRIM5alpha mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants","volume":"3","author":"Kaumanns","year":"2006","journal-title":"Retrovirology"},{"key":"R29-3-20210130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2007.03.017","article-title":"Solution structure of the MID1 B-box2 CHC(D\/C)C(2)H(2) zinc-binding domain: insights into an evolutionarily conserved RING fold","volume":"369","author":"Massiah","year":"2007","journal-title":"J Mol Biol"},{"key":"R30-3-20210130","doi-asserted-by":"crossref","first-page":"10362","DOI":"10.1128\/JVI.00703-07","article-title":"Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain","volume":"81","author":"Diaz-Griffero","year":"2007","journal-title":"J Virol"},{"key":"R31-3-20210130","doi-asserted-by":"crossref","first-page":"26933","DOI":"10.1074\/jbc.M502145200","article-title":"The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5\u03b1","volume":"280","author":"Javanbakht","year":"2005","journal-title":"J Biol Chem"},{"key":"R32-3-20210130","doi-asserted-by":"crossref","first-page":"11495","DOI":"10.1128\/JVI.01548-08","article-title":"The TRIM5alpha B-box 2 domain promotes cooperative binding to the retroviral capsid by mediating higher-order self-association","volume":"82","author":"Li","year":"2008","journal-title":"J Virol"},{"key":"R33-3-20210130","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modeling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/QAD.0b013e328331567a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:08:45Z","timestamp":1786039725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002030-200910230-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,23]]},"references-count":33,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e328331567a","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10,23]]}}}