{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:00:27Z","timestamp":1791216027459,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,14]]},"DOI":"10.1097\/qad.0b013e32834e1567","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T01:23:32Z","timestamp":1321406612000},"page":"127-137","source":"Crossref","is-referenced-by-count":63,"title":["A glycomimetic compound inhibits DC-SIGN-mediated HIV infection in cellular and cervical explant models"],"prefix":"10.1097","volume":"26","author":[{"given":"Angela","family":"Berzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J.","family":"Reina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ottria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieva","family":"Sutkeviciute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Antonazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Sanchez-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chabrol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Biasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Trabattoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Fieschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-2-20210130","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(08)70254-8","article-title":"Vaginal microbicides and the prevention of HIV infection.","volume":"8","author":"Cutler","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"R3-2-20210130","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4155\/fmc.10.203","article-title":"HIV microbicides: state-of-the-art and new perspectives on the development of entry inhibitors.","volume":"2","author":"Reina","year":"2010","journal-title":"Future Med Chem"},{"key":"R4-2-20210130","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0092-8674(00)80693-5","article-title":"Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses.","volume":"100","author":"Geijtenbeek","year":"2000","journal-title":"Cell"},{"key":"R5-2-20210130","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nm0703-847","article-title":"Transmission, cute HIV infection and the quest for strategies to prevent infection.","volume":"9","author":"Pope","year":"2003","journal-title":"Nat Med"},{"key":"R6-2-20210130","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nri1960","article-title":"Dendritic-cell interactions with HIV: infection and viral dissemination.","volume":"6","author":"Wu","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"R7-2-20210130","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80694-7","article-title":"DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T Cells.","volume":"100","author":"Geijtenbeek","year":"2000","journal-title":"Cell"},{"key":"R8-2-20210130","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nri1182","article-title":"DC-SIGN: escape mechanism for pathogens.","volume":"3","author":"Van Kooyk","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"R9-2-20210130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1074-7613(02)00259-5","article-title":"DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection.","volume":"16","author":"Kwon","year":"2002","journal-title":"Immunity"},{"key":"R10-2-20210130","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.1084238","article-title":"Recruitment of HIV and its receptors to dendritic cell-T cell junctions.","volume":"300","author":"McDonald","year":"2003","journal-title":"Science"},{"key":"R11-2-20210130","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1073\/pnas.0507995103","article-title":"Immature dendritic cells derived exosomes can mediate HIV-1 trans infection.","volume":"103","author":"Wiley","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"R12-2-20210130","doi-asserted-by":"crossref","first-page":"12028","DOI":"10.1128\/JVI.75.24.12028-12038.2001","article-title":"Cis expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a co-receptor.","volume":"75","author":"Lee","year":"2001","journal-title":"J Virol"},{"key":"R13-2-20210130","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1182\/blood-2003-09-3129","article-title":"Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.","volume":"103","author":"Turville","year":"2003","journal-title":"Blood"},{"key":"R14-2-20210130","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.immuni.2007.03.012","article-title":"C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-B.","volume":"26","author":"Gringhuis","year":"2007","journal-title":"Immunity"},{"key":"R15-2-20210130","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ni1470","article-title":"Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication.","volume":"8","author":"Hodges","year":"2007","journal-title":"Nat Immunol"},{"key":"R16-2-20210130","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/ni.1858","article-title":"HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells.","volume":"11","author":"Gringhuis","year":"2010","journal-title":"Nat Immunol"},{"key":"R17-2-20210130","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/ni.1778","article-title":"Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.","volume":"10","author":"Gringhuis","year":"2010","journal-title":"Nat Immunol"},{"key":"R18-2-20210130","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1126\/science.1066371","article-title":"Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.","volume":"294","author":"Feinberg","year":"2001","journal-title":"Science"},{"key":"R19-2-20210130","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.chembiol.2004.04.010","article-title":"Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120protein interactions.","volume":"11","author":"Adams","year":"2004","journal-title":"Chem Biol"},{"key":"R20-2-20210130","first-page":"1030","article-title":"1,2 Mannobioside mimic: synthesis, DC-SIGN interaction by NMR and docking, and antiviral activity.","volume":"2","author":"Reina","year":"2007","journal-title":"Chem MedChem"},{"key":"R21-2-20210130","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/jac\/dkh399","article-title":"Glycodendritic structures: promising new antiviral drugs.","volume":"54","author":"Rojo","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"R22-2-20210130","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1021\/bc2000403","article-title":"Pseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola pseudotyped viral infection.","volume":"22","author":"Luczkowiak","year":"2011","journal-title":"Bioconj Chem"},{"key":"R23-2-20210130","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/cb900216e","article-title":"Inhibition of DC-SIGN-mediated infecion by a linear trimannoside mimic in a tetravalent presentation.","volume":"5","author":"Sattin","year":"2010","journal-title":"ACS Chem Biol"},{"key":"R24-2-20210130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/QAD.0b013e328333acfb","article-title":"Caveat associated with the use of human cervical tissue for HIV and microbicide research.","volume":"24","author":"Anderson","year":"2010","journal-title":"AIDS"},{"key":"R25-2-20210130","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1128\/JVI.74.12.5577-5586.2000","article-title":"Parameters of Human Immunodeficiency Virus Infection of human cervical tissue and inhibition by vaginal virucides.","volume":"74","author":"Greenhead","year":"2000","journal-title":"J Virol"},{"key":"R26-2-20210130","doi-asserted-by":"crossref","first-page":"9175","DOI":"10.1128\/JVI.00820-09","article-title":"Human immunodeficiency virus type 1 nucleocapsid inhibitors impede trans infection in cellular and explant models and protect nonhuman primates from infection.","volume":"83","author":"Wallace","year":"2009","journal-title":"J Virol"},{"key":"R27-2-20210130","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1128\/AAC.01129-06","article-title":"Preclinical testing of candidate topical microbicides for antihuman immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture.","volume":"51","author":"Cummins","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"R28-2-20210130","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1021\/bi802151w","article-title":"Structural studies of Langerin and Birbeck granule: a macromolecular organization model.","volume":"48","author":"Thepaut","year":"2009","journal-title":"Biochemistry"},{"key":"R29-2-20210130","doi-asserted-by":"crossref","first-page":"21229","DOI":"10.1074\/jbc.M109.021204","article-title":"DC-SIGN neck domain is a pH-sensor controlling oligomerization: SAXS and hydrodynamic studies of extracellular domain.","volume":"284","author":"Tabarani","year":"2009","journal-title":"J Biol Chem"},{"key":"R30-2-20210130","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1074-7613(02)00447-8","article-title":"Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.","volume":"17","author":"Halary","year":"2002","journal-title":"Immunity"},{"key":"R31-2-20210130","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1039\/c1ob05573a","article-title":"Second generation of fucose-based DC-SIGN ligands: affinity improvement and specificity versus Langerin.","volume":"9","author":"Andreini","year":"2011","journal-title":"Org Biomol Chem"},{"key":"R32-2-20210130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virol.2003.09.028","article-title":"Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN- mediated HIV transmission.","volume":"318","author":"Wu","year":"2004","journal-title":"Virology"},{"key":"R33-2-20210130","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nm1541","article-title":"Langerin is natural barrier to HIV-1 transmission by langerhans cells.","volume":"13","author":"de Witte","year":"2007","journal-title":"Nat Med"},{"key":"R34-2-20210130","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.molmed.2007.11.001","article-title":"Distinct roles for DC-SING-dentritic cells and langherans cells in HIV-1 transmission.","volume":"14","author":"de Witte","year":"2007","journal-title":"Trends Mol Med"},{"key":"R35-2-20210130","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nsmb784","article-title":"Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.","volume":"11","author":"Guo","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"R36-2-20210130","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/intimm\/dxh089","article-title":"High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and Langerin.","volume":"16","author":"Galustian","year":"2004","journal-title":"Int Immunol"},{"key":"R37-2-20210130","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/cbic.200800139","article-title":"Synthesis of novel DC-SIGN ligands with an alpha-fucosylamide anchor.","volume":"9","author":"Timpano","year":"2008","journal-title":"ChemBioChem"},{"key":"R38-2-20210130","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1084\/jem.179.4.1109","article-title":"Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocytemacrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.","volume":"179","author":"Sallusto","year":"1994","journal-title":"J Exp Med"},{"key":"R39-2-20210130","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.1193748","article-title":"Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.","volume":"329","author":"Abdool Karim","year":"2010","journal-title":"Science"},{"key":"R40-2-20210130","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1073\/pnas.0712326105","article-title":"Targeting the carbohydrates on HIV-1: interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN.","volume":"105","author":"Wang","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"R41-2-20210130","first-page":"1806","article-title":"Multivalent manno-glyconanoparticles inhibit DC-SIGN-mediated HIV-1 trans-infection of human T cells.","volume":"10","author":"Martinez-Avila","year":"2009","journal-title":"Chem Biochem"},{"key":"R42-2-20210130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/156652308785160674","article-title":"CCR5 as target for HIV-1 gene therapy.","volume":"8","author":"Nazari","year":"2008","journal-title":"Curr Gene Ther"},{"key":"R44-2-20210130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/jac\/dkg079","article-title":"Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance.","volume":"51","author":"Spira","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"R45-2-20210130","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/382722a0","article-title":"Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.","volume":"26","author":"Samson","year":"1996","journal-title":"Nature"},{"key":"R46-2-20210130","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1084\/jem.186.8.1373","article-title":"Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding.","volume":"186","author":"Wu","year":"1997","journal-title":"J Exp Med"},{"key":"R47-2-20210130","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.270.5243.1811","article-title":"Identification of RANTES, MIP-1(, and MIP-1( as the major HIV-1-suppressive factors produced by CD8 T cells.","volume":"270","author":"Cocchi","year":"1995","journal-title":"Science"},{"key":"R48-2-20210130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1530\/jrf.0.0200085","article-title":"Comparison of vaginal tolerance tests of spermicidal preparations in rabbits and monkeys.","volume":"20","author":"Eckstein","year":"1969","journal-title":"J Reprod Fertil"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/QAD.0b013e32834e1567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:31:51Z","timestamp":1786048311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002030-201201140-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,14]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e32834e1567","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1,14]]}}}