{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:23:32Z","timestamp":1792427012747,"version":"4.5.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,28]]},"DOI":"10.1097\/qad.0b013e32835b3e47","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T13:49:44Z","timestamp":1357220984000},"page":"347-356","source":"Crossref","is-referenced-by-count":31,"title":["Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders"],"prefix":"10.1097","volume":"27","author":[{"given":"Yisel","family":"Cantres-Rosario","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marines","family":"Plaud-Valent\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamil","family":"Gerena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Skolasky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Wojna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loyda M.","family":"Mel\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210130","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1212\/01.WNL.0000287431.88658.8b","article-title":"Updated research nosology for HIV-associated neurocognitive disorders (HAND).","volume":"69","author":"Antinori","year":"2007","journal-title":"Neurology"},{"key":"R2-5-20210130","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study.","volume":"75","author":"Heaton","year":"2010","journal-title":"Neurology"},{"key":"R3-5-20210130","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/ana.22053","article-title":"Human immunodeficiency virus-associated neurocognitive disorders: mind the gap.","volume":"67","author":"McArthur","year":"2010","journal-title":"Ann Neurol"},{"key":"R4-5-20210130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11904-010-0070-4","article-title":"Pathogenesis of HIV in the central nervous system.","volume":"8","author":"Valcour","year":"2011","journal-title":"Curr HIVAIDS Rep"},{"key":"R5-5-20210130","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/35073667","article-title":"Pathways to neuronal injury and apoptosis in HIV-associated dementia.","volume":"410","author":"Kaul","year":"2001","journal-title":"Nature"},{"key":"R6-5-20210130","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/prca.201000010","article-title":"Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants.","volume":"4","author":"Kraft-Terry","year":"2011","journal-title":"Proteomics Clin Appl"},{"key":"R7-5-20210130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11481-010-9253-4","article-title":"Proteomic analysis of HIV-infected macrophages.","volume":"6","author":"Melendez","year":"2011","journal-title":"J Neuroimmune Pharmacol"},{"key":"R8-5-20210130","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nri1110","article-title":"Lysosomal cysteine proteases regulate antigen presentation.","volume":"3","author":"Honey","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"R9-5-20210130","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1046\/j.1471-4159.2001.00146.x","article-title":"Microglial secreted cathepsin B induces neuronal apoptosis.","volume":"76","author":"Kingham","year":"2001","journal-title":"J Neurochem"},{"key":"R10-5-20210130","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00018-004-4445-9","article-title":"Proteinaceous cysteine protease inhibitors.","volume":"62","author":"Dubin","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"R11-5-20210130","first-page":"1437","article-title":"Mononuclear phagocyte hydrolytic enzyme activity associated with cerebral HIV-1 infection.","volume":"151","author":"Gelman","year":"1997","journal-title":"Am J Pathol"},{"key":"R12-5-20210130","doi-asserted-by":"crossref","first-page":"e36571","DOI":"10.1371\/journal.pone.0036571","article-title":"Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.","volume":"7","author":"Rodriguez-Franco","year":"2012","journal-title":"PLoS One"},{"key":"R13-5-20210130","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1212\/WNL.41.6.778","article-title":"Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection.","volume":"41","year":"1991","journal-title":"Neurology"},{"key":"R14-5-20210130","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1212\/WNL.47.5.1247","article-title":"Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitivemotor disorder.","volume":"47","year":"1996","journal-title":"Neurology"},{"key":"R15-5-20210130","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/13550280600964576","article-title":"Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment.","volume":"12","author":"Wojna","year":"2006","journal-title":"J Neurovirol"},{"key":"R17-5-20210130","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.virol.2007.01.013","article-title":"Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome.","volume":"363","author":"Ciborowski","year":"2007","journal-title":"Virology"},{"key":"R18-5-20210130","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1074\/jbc.M008944200","article-title":"Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.","volume":"276","author":"Stoka","year":"2001","journal-title":"J Biol Chem"},{"key":"R19-5-20210130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pneurobio.2009.09.003","article-title":"The role of lysosomal rupture in neuronal death.","volume":"89","author":"Yamashima","year":"2009","journal-title":"Prog Neurobiol"},{"key":"R20-5-20210130","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3233\/JAD-2011-110101","article-title":"The cysteine protease inhibitor, E64d, reduces brain amyloid- and improves memory deficits in Alzheimers disease animal models by inhibiting cathepsin B, but not BACE1, -secretase activity.","volume":"26","author":"Hook","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"R21-5-20210130","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1212\/WNL.55.12.1828","article-title":"Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases.","volume":"55","author":"Nagai","year":"2000","journal-title":"Neurology"},{"key":"R22-5-20210130","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2353\/ajpath.2010.100461","article-title":"Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy.","volume":"177","author":"Kaur","year":"2010","journal-title":"Am J Pathol"},{"key":"R23-5-20210130","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0140-6736(96)10178-1","article-title":"Unique monocyte subset in patients with AIDS dementia.","volume":"349","author":"Pulliam","year":"1997","journal-title":"Lancet"},{"key":"R25-5-20210130","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1189\/jlb.0503204","article-title":"The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection.","volume":"74","author":"Crowe","year":"2003","journal-title":"J Leukoc Biol"},{"key":"R26-5-20210130","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.4049\/jimmunol.178.10.6581","article-title":"The CD16 monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo.","volume":"178","author":"Ellery","year":"2007","journal-title":"J Immunol"},{"key":"R27-5-20210130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4137\/III.S2011","article-title":"Characteristics of activated monocyte phenotype support R5-tropic human immunodeficiency virus.","volume":"1","author":"Munsaka","year":"2009","journal-title":"Immunol Immunogenet Insights"},{"key":"R28-5-20210130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1176\/appi.neuropsych.11050109","article-title":"Cognitive performance related to HIV-1-infected monocytes.","volume":"24","author":"Kusao","year":"2012","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"R29-5-20210130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s13365-010-0013-2","article-title":"Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals.","volume":"17","author":"Letendre","year":"2011","journal-title":"J Neurovirol"},{"key":"R30-5-20210130","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/infdis\/jir387","article-title":"Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden.","volume":"204","author":"Spudich","year":"2011","journal-title":"J Infect Dis"},{"key":"R31-5-20210130","doi-asserted-by":"crossref","first-page":"e19352","DOI":"10.1371\/journal.pone.0019352","article-title":"CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B.","volume":"6","author":"Yoshii","year":"2011","journal-title":"PLoS One"},{"key":"R32-5-20210130","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.antiviral.2011.11.009","article-title":"Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells.","volume":"93","author":"Ha","year":"2012","journal-title":"Antiviral Res"},{"key":"R33-5-20210130","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.placenta.2008.09.005","article-title":"Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages.","volume":"29","author":"Luciano-Montalvo","year":"2008","journal-title":"Placenta"},{"key":"R34-5-20210130","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1189\/jlb.0809571","article-title":"HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complications.","volume":"87","author":"Valcour","year":"2010","journal-title":"J Leukoc Biol"},{"key":"R36-5-20210130","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3233\/JAD-2010-101023","article-title":"Higher cathepsin B levels in plasma in Alzheimers disease compared to healthy controls.","volume":"22","author":"Sundelof","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"R37-5-20210130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbapap.2011.08.015","article-title":"Cysteine cathepsins in the secretory vesicle produce active peptides: cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimers disease.","volume":"1824","author":"Hook","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"R38-5-20210130","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1002\/jnr.22453","article-title":"Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway.","volume":"88","author":"Luo","year":"2010","journal-title":"J Neurosci Res"},{"key":"R39-5-20210130","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1046\/j.1460-9568.1998.00184.x","article-title":"Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on calpain-cathepsin hypothesis.","volume":"10","author":"Yamashima","year":"1998","journal-title":"Eur J Neurosci"},{"key":"R40-5-20210130","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1515\/BC.2005.151","article-title":"Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimers disease.","volume":"386","author":"Hook","year":"2005","journal-title":"Biol Chem"},{"key":"R42-5-20210130","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jneuroim.2007.08.004","article-title":"CSF proteomic fingerprints for HIV-associated cognitive impairment.","volume":"192","author":"Perez-Laspiur","year":"2007","journal-title":"J Neuroimmunol"},{"key":"R43-5-20210130","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1021\/pr070220c","article-title":"Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment.","volume":"6","author":"Rozek","year":"2007","journal-title":"J Proteome Res"},{"key":"R44-5-20210130","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1212\/01.wnl.0000260610.79853.47","article-title":"Associative and predictive biomarkers of dementia in HIV-1-infected patients.","volume":"68","author":"Bandaru","year":"2007","journal-title":"Neurology"},{"key":"R45-5-20210130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-5956-7-8","article-title":"Biomarkers of HIV-1 associated dementia: proteomic investigation of sera.","volume":"7","author":"Wiederin","year":"2009","journal-title":"Proteome Sci"},{"key":"R46-5-20210130","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/1531-8249(199909)46:3<391::AID-ANA15>3.0.CO;2-0","article-title":"Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia.","volume":"46","author":"Conant","year":"1999","journal-title":"Ann Neurol"},{"key":"R47-5-20210130","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/QAD.0b013e3283437f9a","article-title":"HIV-1 infection and cognitive impairment in the cART era: a review.","volume":"25","author":"Schouten","year":"2011","journal-title":"AIDS"},{"key":"R48-5-20210130","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s13365-011-0035-4","article-title":"Osteopontin enhances HIV replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals.","volume":"17","author":"Brown","year":"2011","journal-title":"J Neurovirol"},{"key":"R50-5-20210130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jneuroim.2004.08.039","article-title":"Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load.","volume":"157","author":"Pulliam","year":"2004","journal-title":"J Neuroimmunol"},{"key":"R51-5-20210130","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/1471-2164-10-403","article-title":"Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16 and CD16 monocyte subsets.","volume":"10","author":"Ancuta","year":"2009","journal-title":"BMC Genomics"},{"key":"R52-5-20210130","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1126\/science.287.5453.602","article-title":"HIV infection and dementia.","volume":"287","author":"Gartner","year":"2000","journal-title":"Science"},{"key":"R54-5-20210130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jneuroim.2008.10.013","article-title":"Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment.","volume":"206","author":"Velazquez","year":"2009","journal-title":"J Neuroimmunol"},{"key":"R55-5-20210130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11481-010-9253-4","article-title":"Proteomic analysis of HIV-infected macrophages.","volume":"6","author":"Melendez","year":"2011","journal-title":"J Neuroimmune Pharmacol"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00002030-201301280-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:29:59Z","timestamp":1786048199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002030-201301280-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,28]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e32835b3e47","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,28]]}}}