{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:41:00Z","timestamp":1762004460175},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,14]]},"DOI":"10.1097\/qad.0b013e32835c11e8","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T09:00:40Z","timestamp":1352365240000},"page":"163-173","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of IL28B alleles with virologic response patterns and plasma cytokine levels in HIV\/HCV-coinfected patients"],"prefix":"10.1097","volume":"27","author":[{"given":"Amanda","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Rall\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Berenguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda A.","family":"Jim\u00e9nez-Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Cos\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Guzm\u00e1n-Fulgencio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Garc\u00eda-\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Miralles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Benito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Resino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-4-20210130","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/hep.22759","article-title":"Diagnosis, management, and treatment of hepatitis C: an update.","volume":"49","author":"Ghany","year":"2009","journal-title":"Hepatology"},{"key":"R2-4-20210130","first-page":"185","article-title":"Exploring the possibility of an interferon-free treatment regimen for hepatitis C virus infection.","volume":"7","author":"Sulkowski","year":"2011","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"R3-4-20210130","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1086\/630205","article-title":"Rate and timing of hepatitis C virus relapse after a successful course of pegylated interferon plus ribavirin in HIV-infected and HIV-uninfected patients.","volume":"49","author":"Medrano","year":"2009","journal-title":"Clin Infect Dis"},{"key":"R4-4-20210130","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jhep.2008.07.013","article-title":"Treatment predictors of a sustained virologic response in hepatitis B and C.","volume":"49","author":"Kau","year":"2008","journal-title":"J Hepatol"},{"key":"R5-4-20210130","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature08309","article-title":"Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.","volume":"461","author":"Ge","year":"2009","journal-title":"Nature"},{"key":"R6-4-20210130","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ng.447","article-title":"IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.","volume":"41","author":"Suppiah","year":"2009","journal-title":"Nat Genet"},{"key":"R7-4-20210130","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","article-title":"Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.","volume":"41","author":"Tanaka","year":"2009","journal-title":"Nat Genet"},{"key":"R8-4-20210130","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1136\/gut.2010.222976","article-title":"Interferon lambdas: the next cytokine storm.","volume":"60","author":"Kelly","year":"2011","journal-title":"Gut"},{"key":"R9-4-20210130","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1053\/j.gastro.2006.09.052","article-title":"Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics.","volume":"131","author":"Marcello","year":"2006","journal-title":"Gastroenterology"},{"key":"R10-4-20210130","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1053\/j.gastro.2010.11.039","article-title":"Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.","volume":"140","author":"Dill","year":"2011","journal-title":"Gastroenterology"},{"key":"R11-4-20210130","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/hep.24052","article-title":"Hepatitis C pharmacogenetics: state of the art in 2010.","volume":"53","author":"Afdhal","year":"2011","journal-title":"Hepatology"},{"key":"R12-4-20210130","doi-asserted-by":"crossref","first-page":"e13771","DOI":"10.1371\/journal.pone.0013771","article-title":"IL28B SNP rs8099917 is strongly associated with pegylated interferon-alpha and ribavirin therapy treatment failure in HCVHIV-1 coinfected patients.","volume":"5","author":"Aparicio","year":"2010","journal-title":"PLoS One"},{"key":"R13-4-20210130","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/hep.23850","article-title":"Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection.","volume":"52","author":"Grebely","year":"2010","journal-title":"Hepatology"},{"key":"R14-4-20210130","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1053\/j.gastro.2010.10.004","article-title":"IL28B and the control of hepatitis C virus infection.","volume":"139","author":"Balagopal","year":"2010","journal-title":"Gastroenterology"},{"key":"R15-4-20210130","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood-2008-05-078154","article-title":"CD4 T cells: fates, functions, and faults.","volume":"112","author":"Zhu","year":"2008","journal-title":"Blood"},{"key":"R16-4-20210130","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/hep.510250233","article-title":"Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity.","volume":"25","author":"Tsai","year":"1997","journal-title":"Hepatology"},{"key":"R17-4-20210130","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/jac\/dkr595","article-title":"Plasma IL-6 and IL-9 predict the failure of interferon-alpha plus ribavirin therapy in HIVHCV-coinfected patients.","volume":"67","author":"Guzman-Fulgencio","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"R18-4-20210130","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3851\/IMP1864","article-title":"Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-alpha2b plus ribavirin.","volume":"16","author":"Ueyama","year":"2011","journal-title":"Antivir Ther"},{"key":"R19-4-20210130","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2893.2005.00634.x","article-title":"Cytokine profile of peripheral blood mononuclear cells from patients with different outcomes of hepatitis C virus infection.","volume":"12","author":"Gramenzi","year":"2005","journal-title":"J Viral Hepat"},{"key":"R20-4-20210130","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.bbrc.2008.12.114","article-title":"Th1 and Th2 cytokines are elevated in HCV-infected SVR patients treated with interferon-alpha.","volume":"379","author":"Wan","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"R21-4-20210130","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/infdis\/jiq165","article-title":"Association of serum cytokine levels with treatment response to pegylated interferon and ribavirin therapy in genotype 1 chronic hepatitis C patients.","volume":"203","author":"Yoneda","year":"2011","journal-title":"J Infect Dis"},{"key":"R22-4-20210130","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jaci.2009.04.003","article-title":"Development and function of TH17 cells in health and disease.","volume":"123","author":"Louten","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R23-4-20210130","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.4049\/jimmunol.0900995","article-title":"Critical role of IL-17RA in immunopathology of influenza infection.","volume":"183","author":"Crowe","year":"2009","journal-title":"J Immunol"},{"key":"R24-4-20210130","doi-asserted-by":"crossref","first-page":"e13869","DOI":"10.1371\/journal.pone.0013869","article-title":"Decreased ratio of Treg cells to Th17 cells correlates with HBV DNA suppression in chronic hepatitis B patients undergoing entecavir treatment.","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"},{"key":"R25-4-20210130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.clim.2011.02.008","article-title":"Long-term nonprogressors display a greater number of Th17 cells than HIV-infected typical progressors.","volume":"139","author":"Salgado","year":"2011","journal-title":"Clin Immunol"},{"key":"R26-4-20210130","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1086\/655812","article-title":"Hepatitis C virus core protein induces homotolerance and cross-tolerance to Toll-like receptor ligands by activation of Toll-like receptor 2.","volume":"202","author":"Chung","year":"2010","journal-title":"J Infect Dis"},{"key":"R27-4-20210130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jinf.2010.11.003","article-title":"An artificial neural network improves the noninvasive diagnosis of significant fibrosis in HIVHCV coinfected patients.","volume":"62","author":"Resino","year":"2011","journal-title":"J Infect"},{"key":"R28-4-20210130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group.","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"key":"R29-4-20210130","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3851\/IMP1630","article-title":"Incidence of liver cirrhosis in HIV-infected patients with chronic hepatitis B or C in the era of highly active antiretroviral therapy.","volume":"15","author":"Tuma","year":"2010","journal-title":"Antivir Ther"},{"key":"R30-4-20210130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/j.gastro.2004.11.018","article-title":"Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.","volume":"128","author":"Castera","year":"2005","journal-title":"Gastroenterology"},{"key":"R31-4-20210130","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/QAD.0b013e3281084e4d","article-title":"Care of patients coinfected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV-HIV International Panel.","volume":"21","author":"Soriano","year":"2007","journal-title":"AIDS"},{"key":"R32-4-20210130","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1086\/429864","article-title":"A note on exact tests of Hardy-Weinberg equilibrium.","volume":"76","author":"Wigginton","year":"2005","journal-title":"Am J Hum Genet"},{"key":"R33-4-20210130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps.","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"R34-4-20210130","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses.","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"R35-4-20210130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/gm273","article-title":"Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort.","volume":"3","author":"Smith","year":"2011","journal-title":"Genome Med"},{"key":"R36-4-20210130","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/gene.2011.1","article-title":"IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-alpha plus ribavirin therapy in Taiwanese chronic HCV infection.","volume":"12","author":"Chen","year":"2011","journal-title":"Genes Immun"},{"key":"R37-4-20210130","doi-asserted-by":"crossref","first-page":"e18322","DOI":"10.1371\/journal.pone.0018322","article-title":"IL28B SNP rs12979860 is a critical predictor for on-treatment and sustained virologic response in patients with hepatitis C virus genotype-1 infection.","volume":"6","author":"Lin","year":"2011","journal-title":"PLoS One"},{"key":"R38-4-20210130","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1111\/j.1365-2893.2010.01392.x","article-title":"Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort.","volume":"18","author":"Clausen","year":"2011","journal-title":"J Viral Hepat"},{"key":"R39-4-20210130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1001\/jama.2011.975","article-title":"Hepatitis C virus infection and coinfection with human immunodeficiency virus: challenges and advancements in management.","volume":"306","author":"Hadigan","year":"2011","journal-title":"JAMA"},{"key":"R40-4-20210130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cld.2011.05.009","article-title":"Redefining baseline demographics: the role of genetic testing in hepatitis C virus infection.","volume":"15","author":"Holmes","year":"2011","journal-title":"Clin Liver Dis"},{"key":"R41-4-20210130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2893.2011.01497.x","article-title":"IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection.","volume":"19","author":"Rao","year":"2012","journal-title":"J Viral Hepat"},{"key":"R42-4-20210130","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1001\/archinte.164.21.2349","article-title":"Cirrhosis and hepatocellular carcinoma in HIV-infected veterans with and without the hepatitis C virus: a cohort study, 1992-2001.","volume":"164","author":"Giordano","year":"2004","journal-title":"Arch Intern Med"},{"key":"R43-4-20210130","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.21757","article-title":"Clinical progression of hepatitis C virus-related chronic liver disease in human immunodeficiency virus-infected patients undergoing highly active antiretroviral therapy.","volume":"46","author":"Pineda","year":"2007","journal-title":"Hepatology"},{"key":"R44-4-20210130","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1002\/hep.23912","article-title":"IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.","volume":"52","author":"Urban","year":"2010","journal-title":"Hepatology"},{"key":"R45-4-20210130","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1053\/j.gastro.2010.04.049","article-title":"Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C.","volume":"139","author":"Honda","year":"2010","journal-title":"Gastroenterology"},{"key":"R46-4-20210130","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1053\/j.gastro.2008.12.034","article-title":"Analysis of CD8 T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model.","volume":"136","author":"Jo","year":"2009","journal-title":"Gastroenterology"},{"key":"R47-4-20210130","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1073\/pnas.0707882105","article-title":"Interferon signaling and treatment outcome in chronic hepatitis C.","volume":"105","author":"Sarasin-Filipowicz","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R48-4-20210130","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/QAI.0b013e3181d01d05","article-title":"Plasma interferon-gamma-inducible protein-10 can predict virologic response to hepatitis C virus therapy in HIVHCV-coinfected patients with HCV genotype 1.","volume":"54","author":"Vargas","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"R49-4-20210130","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/QAI.0b013e3180559219","article-title":"Interferon gamma-inducible protein 10: a predictive marker of successful treatment response in hepatitis C virusHIV-coinfected patients.","volume":"45","author":"Zeremski","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"R50-4-20210130","first-page":"210","article-title":"Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C.","volume":"23","author":"Larrea","year":"1996","journal-title":"Hepatology"},{"key":"R51-4-20210130","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1096\/fj.00-0908fje","article-title":"Tumor necrosis factor alpha attenuates interferon alpha signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy.","volume":"15","author":"Hong","year":"2001","journal-title":"FASEB J"},{"key":"R52-4-20210130","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jhep.2008.12.021","article-title":"Hepatic SOCS3 expression is strongly associated with nonresponse to therapy and race in HCV and HCVHIV infection.","volume":"50","author":"Kim","year":"2009","journal-title":"J Hepatol"},{"key":"R53-4-20210130","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1128\/JVI.02583-10","article-title":"Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91.","volume":"85","author":"Funaoka","year":"2011","journal-title":"J Virol"},{"key":"R54-4-20210130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1042\/bj3530109","article-title":"Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling.","volume":"353","author":"Lejeune","year":"2001","journal-title":"Biochem J"},{"key":"R55-4-20210130","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tibtech.2004.06.002","article-title":"What is disrupting IFN-alphas antiviral activity.","volume":"22","author":"Mbow","year":"2004","journal-title":"Trends Biotechnol"}],"container-title":["AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/QAD.0b013e32835c11e8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T01:15:18Z","timestamp":1643591718000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00002030-201301140-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,14]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/qad.0b013e32835c11e8","relation":{},"ISSN":["0269-9370"],"issn-type":[{"value":"0269-9370","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,14]]}}}