{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:19:26Z","timestamp":1786119566913,"version":"build-2736575974"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"DOI":"10.1097\/qai.0b013e318213312c","type":"journal-article","created":{"date-parts":[[2011,2,12]],"date-time":"2011-02-12T10:31:44Z","timestamp":1297506704000},"page":"16-23","source":"Crossref","is-referenced-by-count":19,"title":["Lipodystrophy and Insulin Resistance in Combination Antiretroviral Treated HIV-1\u2013Infected Patients: Implication of Resistin"],"prefix":"10.1097","volume":"57","author":[{"given":"Xavier","family":"Escot\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merce","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Veloso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Alonso-Villaverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Peraire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Vilad\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Alba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Olona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"L\u00f3pez-Dupla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan-Josep","family":"Sirvent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Vendrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00f3bal","family":"Richart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20210131","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes.","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"R2-3-20210131","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1172\/JCI20785","article-title":"Adenovirus-mediated chronic hyper-resistinemia leads to in vivo insulin resistance in normal rats.","volume":"114","author":"Satoh","year":"2004","journal-title":"J Clin Invest"},{"key":"R3-3-20210131","doi-asserted-by":"crossref","first-page":"25651","DOI":"10.1074\/jbc.C100189200","article-title":"Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor agonists.","volume":"276","author":"Way","year":"2001","journal-title":"J Biol Chem"},{"key":"R4-3-20210131","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1210\/jc.2002-021808","article-title":"Serum resistin (FIZZ3) protein is increased in obese humans.","volume":"88","author":"Degawa-Yamauchi","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"R5-3-20210131","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1210\/jc.2003-031121","article-title":"Plasma resistin concentrations measured by enzyme- linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus.","volume":"89","author":"Youn","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-3-20210131","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1530\/eje.0.1490331","article-title":"Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance.","volume":"149","author":"Silha","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"R7-3-20210131","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1210\/jc.2003-030519","article-title":"Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects.","volume":"88","author":"Lee","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"R8-3-20210131","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1210\/jc.2003-031410","article-title":"Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects.","volume":"89","author":"Heilbronn","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-3-20210131","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2337\/diabetes.53.5.1279","article-title":"Court, Degawa-Yamauchi M, Considine RV, et al. High serum Resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians.","volume":"53","year":"2004","journal-title":"Diabetes"},{"key":"R10-3-20210131","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1210\/jc.2005-0287","article-title":"Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone.","volume":"90","author":"Kamin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R11-3-20210131","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1210\/jc.2005-0742","article-title":"Circulating resistin levels are not associated with fat redistribution, insulin resistance, or metabolic profile in patients with the highly active antiretroviral therapy-induced metabolic syndrome.","volume":"90","author":"Barb","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R12-3-20210131","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/BF03345607","article-title":"Is resistin a link between highly active antiretroviral therapy and fat redistribution in HIV-infected children?","volume":"31","author":"Spagnuolo","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"R13-3-20210131","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1468-1293.2010.00837.x","article-title":"Adipokine profiles and lipodystrophy in HIV-infected children during the first 4 years on highly active antiretroviral therapy.","volume":"12","author":"Resino","year":"2011","journal-title":"HIV Med"},{"key":"R14-3-20210131","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2337\/dc06-1936","article-title":"Plasma resistin, associated with single nucleotide polymorphism -420 is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C reactive protein in the Japanese general population.","volume":"30","author":"Osawa","year":"2007","journal-title":"Diabetes Care"},{"key":"R15-3-20210131","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ijo.2009.44","article-title":"Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents.","volume":"33","author":"Li","year":"2009","journal-title":"Int J Obes (Lond)"},{"key":"R16-3-20210131","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbrc.2009.02.015","article-title":"Resistin up-regulates fractalkine expression in human endothelial cells: Lack of additive effect with TNF-.","volume":"381","author":"Manduteanu","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"R17-3-20210131","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-2265.2007.03003.x","article-title":"A polymorphism in the Resistin gene promoter and the risk of coronary artery disease in a Chinese population.","volume":"68","author":"Tang","year":"2008","journal-title":"Clin Endocrinol"},{"key":"R18-3-20210131","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1097\/QAD.0b013e32830a9886","article-title":"Genetic analysis implicates resistin in HIV lipodystrophy.","volume":"22","author":"Ranade","year":"2008","journal-title":"AIDS"},{"key":"R19-3-20210131","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(98)08468-2","article-title":"Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia and diabetes mellitus: a cohort study.","volume":"353","author":"Carr","year":"1999","journal-title":"Lancet"},{"key":"R20-3-20210131","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1097\/00002030-199911120-00007","article-title":"Lipodystrophy defined by a clinical score in HIV-infected men on highly active antiretroviral therapy: correlation between dyslipidaemia and steroid hormone alterations.","volume":"13","author":"Christeff","year":"1999","journal-title":"AIDS"},{"key":"R21-3-20210131","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1086\/317541","article-title":"Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy.","volume":"32","author":"Hadigan","year":"2001","journal-title":"Clin Infect Dis"},{"key":"R22-3-20210131","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/jama.287.3.356","article-title":"Prevalence of the metabolic syndrome among US adults: findings from the third National health and Nutrition Examination.","volume":"287","author":"Ford","year":"2002","journal-title":"JAMA"},{"key":"R23-3-20210131","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.","volume":"28","author":"Mattews","year":"1985","journal-title":"Diabetologia"},{"key":"R24-3-20210131","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/QAD.0b013e3282f4dde7","article-title":"A study on the IL-6 system in HIV-1-infected patients.","volume":"22","author":"Saumoy","year":"2008","journal-title":"AIDS"},{"key":"R25-3-20210131","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.drugalcdep.2007.07.008","article-title":"A study on the TNF- system in Caucasian Spanish patients with alcoholic liver disease.","volume":"92","author":"Auguet","year":"2008","journal-title":"Drug Alcohol Depend"},{"key":"R26-3-20210131","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(03)12656-6","article-title":"An objective case definition of lipodystrophy in HIV-infected adults: a case-control study.","volume":"361","year":"2003","journal-title":"Lancet"},{"key":"R27-3-20210131","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1097\/00002030-200210180-00005","article-title":"TNF- promoter region gene polymorphisms in HIV-positive patients with lipodystrophy.","volume":"16","author":"Maher","year":"2002","journal-title":"AIDS"},{"key":"R28-3-20210131","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00002030-200301030-00017","article-title":"Tumor necrosis factor-alpha gene -238G\/A promoter polymorphism associated with a more rapid onset of lipodystrophy.","volume":"17","author":"Nolan","year":"2003","journal-title":"AIDS"},{"key":"R29-3-20210131","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1086\/429295","article-title":"Modeling the influence of APOC3, APOE and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders.","volume":"191","author":"Tarr","year":"2005","journal-title":"J Infect Dis"},{"key":"R30-3-20210131","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1097\/00002030-200007070-00027","article-title":"3-Adrenergic receptor polymorphism and the antiretroviral therapy-related lipodystrophy syndrome.","volume":"14","author":"Vonkeman","year":"2000","journal-title":"AIDS"},{"key":"R31-3-20210131","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/157016209789346219","article-title":"PPAR Pro12Ala polymorphism in HIV-1-infected patients with HAART-related lipodystrophy.","volume":"7","author":"Saumoy","year":"2009","journal-title":"Curr HIV Res"},{"key":"R32-3-20210131","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3346\/jkms.2009.24.4.695","article-title":"Association of plasma levels of resistin with subcutaneous fat mass and markers of inflammation but not with metabolic determinants or insulin resistance.","volume":"4","author":"Won","year":"2009","journal-title":"J Korean Med Sci"},{"key":"R33-3-20210131","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1507\/endocrj.K08E-320","article-title":"A pilot study suggests that the G\/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes.","volume":"56","author":"Makino","year":"2009","journal-title":"Endocr J"},{"key":"R34-3-20210131","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/09513590902972042","article-title":"The contributions of resistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population.","volume":"25","author":"Baba","year":"2009","journal-title":"Gynecol Endocrinol"},{"key":"R35-3-20210131","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2265.2007.03154.x","article-title":"Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes.","volume":"1","author":"Osawa","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R36-3-20210131","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.2337\/db06-1157","article-title":"Frequency of the G\/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes.","volume":"56","author":"Ochi","year":"2007","journal-title":"Diabetes"},{"key":"R37-3-20210131","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s00125-009-1517-2","article-title":"Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population.","volume":"53","author":"Asano","year":"2010","journal-title":"Diabetologia"},{"key":"R38-3-20210131","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng749","article-title":"Replication validity of genetic association studies.","volume":"29","author":"Ioannidis","year":"2001","journal-title":"Nat Genet"},{"key":"R39-3-20210131","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1371\/journal.pone.0000031","article-title":"Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes.","volume":"1","author":"Nagaev","year":"2006","journal-title":"PLoS One"},{"key":"R40-3-20210131","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1210\/jc.2006-2545","article-title":"Innate immunity modulates adipokines in humans.","volume":"92","author":"Anderson","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R41-3-20210131","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/oby.2008.607","article-title":"Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes.","volume":"17","author":"Kopp","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"R42-3-20210131","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.diabet.2010.05.003","article-title":"Correlation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients.","volume":"36","author":"Gharibeh","year":"2010","journal-title":"Diabetes Metab"}],"container-title":["JAIDS Journal of Acquired Immune Deficiency Syndromes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/QAI.0b013e318213312c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:52:16Z","timestamp":1786042336000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00126334-201105010-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/qai.0b013e318213312c","relation":{},"ISSN":["1525-4135"],"issn-type":[{"value":"1525-4135","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5,1]]}}}